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High mobility group box 2

HMG2, HMGB2, Hmg2p
This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HMGB1, CAN, ACID, Histone, HAD
Papers on HMG2
Loss of Endometrial Plasticity in Recurrent Pregnancy Loss.
Brosens et al., Singapore, Singapore. In Stem Cells, Oct 2015
Loss of epigenetic stemness features also correlated with intragenic CpG hypomethylation and reduced expression of HMGB2, coding high mobility group protein 2. We show that knockdown of this sequence-independent chromatin protein in HESCs promotes senescence and impairs decidualization, exemplified by blunted time-dependent secretome changes.
Disruption of Parasite hmgb2 Gene Attenuates Plasmodium berghei ANKA Pathogenicity.
Vaquero et al., Paris, France. In Infect Immun, Jul 2015
We found that the Plasmodium genome encodes two genuine HMGB factors, Plasmodium HMGB1 and HMGB2, that encompass, like their human counterparts, a proinflammatory domain.
Antisense RNA controls LRP1 Sense transcript expression through interaction with a chromatin-associated protein, HMGB2.
Wahlestedt et al., Miami, United States. In Cell Rep, Jun 2015
We show that Lrp1-AS directly binds to high-mobility group box 2 (Hmgb2) and inhibits the activity of Hmgb2 to enhance Srebp1a-dependent transcription of Lrp1.
Upregulation of MicroRNA-19b predicts good prognosis in patients with hepatocellular carcinoma presenting with vascular invasion or multifocal disease.
Yen et al., Taiwan. In Bmc Cancer, 2014
N-myc downstream regulated 1 (NDRG1) was downregulated, while epithelial cell adhesion molecule (EPCAM), hypoxia-inducible factor 1-alpha (HIF1A), high-mobility group protein B2 (HMGB2), and mitogen activated protein kinase 14 (MAPK14) were upregulated when miR-19b was knocked down in Hep3B.
Identification of genes associated with methotrexate resistance in methotrexate-resistant osteosarcoma cell lines.
Gong et al., Chengdu, China. In J Orthop Surg Res, 2014
Totally, 13 TFs (including HMGB2), 13 oncogenes (including CCNA2 and AURKA), and 19 tumor suppressor genes (TSGs) (including CDKN2C) were identified from the down-regulated DEGs.
miR-23b-3p regulates the chemoresistance of gastric cancer cells by targeting ATG12 and HMGB2.
Zhao et al., Xi'an, China. In Cell Death Dis, 2014
Reporter gene assay and western blot analysis showed that ATG12 and HMGB2 were the direct targets of miR-23b-3p.
Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach.
Hacohen et al., Cambridge, United States. In Nat Immunol, 2013
We identified ABCF1 as a critical protein that associates with dsDNA and the DNA-sensing components HMGB2 and IFI204.
Quantitative analysis of the chromatin proteome in disease reveals remodeling principles and identifies high mobility group protein B2 as a regulator of hypertrophic growth.
Vondriska et al., Los Angeles, United States. In Mol Cell Proteomics, 2012
HMGB2 (but not HMGB1) suppresses pathologic cell growth in vivo and controls a gene expression program responsible for hypertrophic cell growth
Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation.
Lotz et al., Los Angeles, United States. In J Biol Chem, 2012
The age-related loss of HMGB2 in articular cartilage may represent a mechanism responsible for the decline in adult cartilage stem cell populations.
The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.
Hampton et al., San Diego, United States. In J Biol Chem, 2011
The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2.
HMGB factors are required for posterior digit development through integrating signaling pathway activities.
Kawakami et al., Minneapolis, United States. In Dev Dyn, 2011
Data show that Hmgb1 and Hmgb2 function redundantly to enhance Wnt signaling in embryos, and further suggest that integrating Wnt, Shh, and BMP signaling regulates the development of digit5 in forelimbs.
Nucleocytoplasmic distribution of the Arabidopsis chromatin-associated HMGB2/3 and HMGB4 proteins.
Grasser et al., Aalborg, Denmark. In Plant Physiol, 2010
results show that, in contrast to other Arabidopsis HMGB proteins such as HMGB1 and HMGB5, the HMGB2/3 and HMGB4 proteins occur preferentially in the cell nucleus, but to various extents also in the cytoplasm
Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.
Roeder et al., New York City, United States. In Cell, 2006
The purification of CTEA also identified HMGB2 as a coactivator that, while inactive on its own, enhances SII and p300 functions.
Recruitment of Drosophila Polycomb group proteins to chromatin by DSP1.
Cavalli et al., Montpellier, France. In Nature, 2005
Here we show that the Dorsal switch protein 1 (DSP1), a Drosophila HMGB2 homologue, binds to a sequence present within Ab-Fab and in other characterized PREs.
Nuclear war: the granzyme A-bomb.
Fan et al., Boston, United States. In Curr Opin Immunol, 2003
A special target of the granzyme A cell death pathway is an endoplasmic reticulum-associated complex, called the SET complex, which contains three granzyme A substrates, the nucleosome assembly protein SET, the DNA bending protein HMG-2, and the base excision repair endonuclease Ape1.
Genomic analysis of facioscapulohumeral muscular dystrophy.
Hewitt et al., In Brief Funct Genomic Proteomic, 2003
A recent study has identified a protein complex bound to D4Z4 that contains YY1 and HMGB2, implicating a role for D4Z4 as a repressor.
Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor.
Lieberman et al., Boston, United States. In Cell, 2003
A GzmA-activated DNase (GAAD) is in an ER associated complex containing pp32 and the GzmA substrates SET, HMG-2, and Ape1.
Extrachromosomal recombination substrates recapitulate beyond 12/23 restricted VDJ recombination in nonlymphoid cells.
Alt et al., Boston, United States. In Immunity, 2003
Finally, purified core RAG1 and RAG2 proteins (together with HMG2) also reproduce B12/23 restriction in a cell-free system.
Genetic analysis of hydroxymethylglutaryl-coenzyme A reductase regulated degradation.
Hampton, Los Angeles, United States. In Curr Opin Lipidol, 1998
In order to discover the molecules that mediate the degradation process and its control, we conducted a genetic analysis of the degradation of the yeast Hmg2p isozyme of hydroxymethylglutaryl-coenzyme A reductase.
RAGged repair: what's new in V(D)J recombination.
Hagmann, Z├╝rich, Switzerland. In Biol Chem, 1997
Hence, it became obvious that the initial steps of the reaction are carried out by the lymphocyte-specific proteins RAG1 and RAG2 (recombination-activating genes), with the help of members of the high mobility group protein family of DNA-binding proteins, HMG1 or HMG2.
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