GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Cholinergic receptor, muscarinic 2
hm2, CHRM2, muscarinic acetylcholine receptor M2, 7TM receptor
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008] (from
NCBI)
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Papers on
hm2
Optical probes based on G protein-coupled receptors - added work or added value?
Review
New
Würzburg, Germany. In Br J Pharmacol, Jan 2016
This novel sensor class was built on the base of GPCRs, which represent an integral transmembrane receptor family passing the membrane seven times and are thus also called the 7TM receptor family.
Brain cholinergic alterations in rats subjected to repeated immobilization or forced swim stress on lambda-cyhalothrin exposure.
New
Lucknow, India. In Neurochem Int, Jan 2016
Decrease in acetylcholinesterase activity, protein expression of ChAT and PKC-β1 associated with decreased mRNA expression of CHRM2, AChE and ChAT in frontal cortex and hippocampus was also evident in rats pre-exposed to IMS or FSS on LCT treatment, compared to rats exposed to IMS or FSS or LCT alone.
Genetic Polymorphism of CHRM2 in COPD: Clinical Significance and Therapeutic Implications.
New
Roma, Italy. In J Cell Physiol, Jan 2016
Eighty-two patients with COPD and 17 healthy smokers were recruited and screened for ADRb2 (T164I and R175R), for CHRM2 (rs1824024) and for CHRM3 (-513C/A and -492C/T).
The Role of Muscarinic Receptors in the Pathophysiology of Mood Disorders:A Potential Noveltreatment?
Review
New
Australia. In Curr Neuropharmacol, Dec 2015
This review presents recent data from neuroimaging, post-mortem and genetic studies supporting the involvement of muscarinic cholinergic receptors (CHRMs), particularly CHRM2, in the pathophysiology of MDD and BPD.
[Suitability of spatial pattern of camping sites in Langxiang Natural Reserve, Northeast Chi- na, based on GIS technology].
New
In Ying Yong Sheng Tai Xue Bao, Sep 2015
The area of forest sub-compartments which were suitable for camping was 1094.44 hm2, being 12.2% of the experimental zone.
[Spatial heterogeneity of community structure of Picea crassifolia forest in Qilian Mountains, China].
New
In Ying Yong Sheng Tai Xue Bao, Sep 2015
Density and coverage for the spatial heterogeneity of community structural of P. crassifolia forests were 10 m and 0.5 hm2, respectively.
[Distribution and Dynamics of Cropland Soil Organic Carbon in Jianghan Plain: A Case Study of Qianjiang City].
New
In Huan Jing Ke Xue, Sep 2015
(hm2.a)-1, and SOC storage was reduced by 9% with the decreasing rate of 1. 53 t.a-1.
[Quadratic Orthogonal Rotation Combination Design on Alisma orientalis of Fertilization].
New
In Zhong Yao Cai, Apr 2015
The results of the frequency analysis showed that for the target yield over 8 250 kg/hm2 and the confidence interval of 95%, the optimal fertilizer application rates were as follows :nitrogen of 241.
Possible involvement of muscarinic receptors in psychiatric disorders: a focus on schizophrenia and mood disorders.
Review
Australia. In Curr Mol Med, 2014
This review will focus on data suggesting changes in levels of CHRM1 and CHRM4 implicate these receptors in the pathophysiology of schizophrenia whereas data suggest a role for CHRM2 in mood disorders.
EBV, the human host, and the 7TM receptors: defense or offense?
Review
Copenhagen, Denmark. In Prog Mol Biol Transl Sci, 2014
The 7TM receptor encoded by EBV-BILF1, is known to downregulate cell surface MHC class I expression as part of the immune evasion strategy of EBV.
Differential gene expression in relation to the clinical characteristics of human brain arteriovenous malformations.
Review
Kyoto, Japan. In Neurol Med Chir (tokyo), 2013
The neuron-related genes were NPY, S100A9, NeuroD2, S100Abeta, CAMK2A, SYNPR, CHRM2, and CAMKV.
[Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].
GeneRIF
Brescia, Italy. In Urologia, 2012
Exposure to the cholinergic agonist carbachol induced a concentration-dependent increase in cell proliferation rate. This effect was mainly mediated by the receptor subtypes M3 and M2.
Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist.
Impact
GeneRIF
Tokyo, Japan. In Nature, 2012
Xray structure of the antagonist-bound human M2 receptor, the first human acetylcholine receptor to be characterized structurally
Autoimmunity against the β2 adrenergic receptor and muscarinic-2 receptor in complex regional pain syndrome.
GeneRIF
Gießen, Germany. In Pain, 2011
Identification of functionally active autoantibodies to CHRM2 in serum samples from complex regional pain syndrome (CRPS) patients supports an autoimmune pathogenesis of CRPS.
Differential susceptibility to adolescent externalizing trajectories: examining the interplay between CHRM2 and peer group antisocial behavior.
GeneRIF
Richmond, United States. In Child Dev, 2011
Findings indicate that relative to a normative "lower risk" externalizing trajectory, likelihood of membership in two "higher risk" trajectories increased with each additional copy of the minor allelic variant at CHRM2.
Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence.
GeneRIF
Albuquerque, United States. In J Abnorm Child Psychol, 2011
SNP rs1455858 associated with adolescent substance abuse and temperamental risk factors
Cellular assays as portals to seven-transmembrane receptor-based drug discovery.
Review
Impact
United States. In Nat Rev Drug Discov, 2009
The need to discover new 7TM receptor-ligand behaviours and quantify the effect of the drug on these complex systems, to guide medicinal chemistry, puts the pharmacological assay into the spotlight.
Molecular mechanism of 7TM receptor activation--a global toggle switch model.
Review
Impact
Hørsholm, Denmark. In Annu Rev Pharmacol Toxicol, 2005
The multitude of chemically highly different agonists for 7TM receptors apparently do not share a common binding mode or active site but nevertheless act through induction of a common molecular activation mechanism.
Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.
Impact
Burlington, United States. In Nature, 1996
In COS-7 cells, cotransfection of hm1 or hm2 receptors with Ras-GRF conferred carbachol-dependent increases in exchange-factor activity, whereas cotransfection with G-protein beta gamma subunits caused a constitutive activation that was sensitive to PP1.
Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes.
Impact
San Francisco, United States. In Nature, 1988
We show that the HM2 and HM3 mAChRs efficiently inhibit adenylyl cyclase activity but poorly activate PI hydrolysis.
