gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Cholinergic receptor, muscarinic 3

HM-3, M3 muscarinic receptor
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: WAVE, HAD, CAN, Hoxa5, AGE
Papers on HM-3
Pharmacokinetics of HM-3 after intravitreal administration in mice.
Xu et al., Nanjing, China. In Curr Eye Res, 2014
PURPOSE: HM-3, an RGD-modified endostatin-derived polypeptide, is a potent angiogenesis inhibitor synthesized in our laboratory.
Treatment efficacy and outcomes using a third generation shockwave lithotripter.
Gillitzer et al., Mainz, Germany. In Bju Int, 2013
To compare the results of the Lithoskop with other currently available systems and the reference standard lithotripter, the HM-3 (Dornier MedTech Europe GmbH, Wessling, Germany).
Evaluation of shock wave lithotripsy injury in the pig using a narrow focal zone lithotriptor.
Lingeman et al., Indianapolis, United States. In Bju Int, 2012
Of all the SW lithotriptors manufactured to date, more research studies have been conducted on and more is known about the injury (both description of injury and how to manipulate injury size) produced by the Dornier HM-3 than any other machine.
Comparison of the activation kinetics of the M3 acetylcholine receptor and a constitutively active mutant receptor in living cells.
Lohse et al., Würzburg, Germany. In Mol Pharmacol, 2012
The Asn-514-Tyr point mutation produces constitutive activation of muscarinic M3-AChR by decreasing the rate of receptor deactivation, while having minimal effect on receptor activation.
Reduction of bubble cavitation by modifying the diffraction wave from a lithotripter aperture.
Zhou, Singapore, Singapore. In J Endourol, 2012
At the lithotripter focus, while only about 30 shocks were needed to rupture a blood vessel phantom using the original HM-3 reflector at 20 kV, no damage could be produced after 300 shocks using the edge extender.
Muscarinic type 3 receptor induces cytoprotective signaling in salivary gland cells through epidermal growth factor receptor transactivation.
Kawai et al., Cambridge, United States. In Mol Pharmacol, 2012
Its cytoprotective effect was decreased by a M3R antagonist.
The role of muscarinic acetylcholine receptor type 3 polypeptide (M3RP205-220) antibody in the saliva of patients with primary Sjögren's syndrome.
Li et al., Beijing, China. In Clin Exp Rheumatol, 2012
The anti-M3RP205-220 antibody was detected in most patients with Sjogren syndrome.
[Acetylcholine induces human detrusor muscle cell proliferation: molecular and pharmacological characterization].
Sigala et al., Brescia, Italy. In Urologia, 2012
Exposure to the cholinergic agonist carbachol induced a concentration-dependent increase in cell proliferation rate. This effect was mainly mediated by the receptor subtypes M3 and M2.
In vitro study on metabolite profiles of bioactive xanthones isolated from Halenia elliptica D. Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry.
Zhang et al., Beijing, China. In J Pharm Biomed Anal, 2012
The metabolisms of five xanthones isolated from a Tibetan medicinal herb Halenia elliptica D. Don, including 1-hydroxy-2,3,5-trimethoxy-xanthone (HM-1), 1-hydroxy-2,3,4,7-tetramethoxy-xanthone (HM-2), 1-hydroxy-2,3,4,5-tetramethoxy-xanthone (HM-3), 1,7-dihydroxy-2,3,4,5-tetramethoxy-xanthone (HM-4) and 1,5-dihydroxy-2,3-dimethoxy-xanthone (HM-5), were studied in rat liver microsomes in vitro.
Twenty-year prevalence of diabetes mellitus and hypertension in patients receiving shock-wave lithotripsy for urolithiasis.
Paterson et al., Vancouver, Canada. In Bju Int, 2012
OBJECTIVES: To compare the prevalence of hypertension and diabetes mellitus (DM) in patients treated with an unmodified HM-3 lithotripter (USWL) and a second-generation modified HM-3 lithotripter (MSWL) 20 years ago at our Centre with that in the provincial population.
Molecular modeling of the M3 acetylcholine muscarinic receptor and its binding site.
Perez et al., Barcelona, Spain. In J Biomed Biotechnol, 2011
The study reports the results of a combined computational and site mutagenesis study designed to provide new insights into the orthosteric binding site of the human M3 muscarinic acetylcholine receptor.
In vivo pharmacokinetics, immunogenicity and mechanism of PEGylated antitumor polypeptide.
Zhang et al., Nanjing, China. In Curr Pharm Des, 2011
HM-3, An RGD (Arg-Gly-Asp)-modified polypeptide derived from endostatin, is a potent angiogenesis inhibitor.
RGD-modified angiogenesis inhibitor HM-3 dose: dual function during cancer treatment.
Liu et al., Nanjing, China. In Bioconjug Chem, 2011
In the present study, we have undertaken pharmacodynamic studies of HM-3 in vitro and in vivo.
In vivo anti-tumor activity of polypeptide HM-3 modified by different polyethylene glycols (PEG).
Xu et al., Nanjing, China. In Int J Mol Sci, 2010
HM-3, designed by our laboratory, is a polypeptide composed of 18 amino acids.
Site-specific modification of anti-angiogenesis peptide HM-3 by polyethylene glycol molecular weight of 20 kDa.
Zhang et al., Nanjing, China. In J Biochem, 2010
HM-3, an RGD modified endostatin-derived polypeptide, is a potent angiogenesis inhibitor synthesized in our laboratory.
Laser lithotripsy.
Teichman, San Antonio, United States. In Curr Opin Urol, 2002
Holmium:yttrium-aluminium-garnet lithotripsy is more effective than pneumatic lithotripsy for ureteral calculi, but no more effective than shock-wave lithotripsy (Dornier HM-3) for distal ureteral calculi.
Structure-function analysis of muscarinic acetylcholine receptors.
Wess et al., Bethesda, United States. In J Physiol Paris, 1998
Mutational analysis of the m3 muscarinic receptor showed that most native cysteine residues are not required for productive receptor/G protein coupling.
Structural basis of receptor/G protein coupling selectivity studied with muscarinic receptors as model systems.
Kostenis et al., Bethesda, United States. In Life Sci, 1996
Extensive mutagenesis studies have previously led to the identification of single amino acids on the m3 muscarinic receptor protein (located in the second intracellular loop (i2) and at the N- and C-terminus of the third intracellular loop (i3)) that dictate selective recognition of Gq/11 proteins by this receptor subtype.
Muscarinic acetylcholine receptors: structural basis of ligand binding and G protein coupling.
Blüml et al., Bethesda, United States. In Life Sci, 1994
Site-directed mutagenesis studies of the rat m3 muscarinic receptor suggest that the acetylcholine binding domain is formed by a series of hydrophilic amino acids located in the "upper" half of transmembrane domains (TM) III, V, VI, and VII.
Are auxiliary methods necessary prior to ESWL in patients with a solitary kidney?
Frohmüller et al., Würzburg, Germany. In Urol Int, 1993
Between January 1985 and October 1991, 54 patients with calculi in a solitary kidney were treated by ESWL using the Dornier HM-3 lithotriptor.
share on facebooktweetadd +1mail to friends