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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

H2.0-like homeobox

Hlx, HB24, HLX1
Top mentioned proteins: T-bet, BET, HAD, TH2, GATA3
Papers on Hlx
H2.0-like homeobox 1 acts as a tumor suppressor in hepatocellular carcinoma.
Lei et al., Changsha, China. In Tumour Biol, Jan 2016
UNASSIGNED: H2.0-like homeobox 1 (HLX1) is a homeobox transcription factor gene expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta and involved in the development of enteric nervous system.
PAK1 is a therapeutic target in acute myeloid leukemia and myelodysplastic syndrome.
Steidl et al., Oxford, United Kingdom. In Blood, Sep 2015
We recently identified p21-activated kinase (PAK1) as a downstream effector molecule of H2.0-like homeobox (HLX), a gene functionally relevant for AML pathogenesis.
A role for BMP-induced homeobox gene MIXL1 in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy.
Nagarajan et al., Houston, United States. In Oncotarget, 2015
Mesoderm Inducer in Xenopus Like1 (MIXL1), a paired-type homeobox transcription factor induced by TGF-β family of ligands is required for early embryonic specification of mesoderm and endoderm.
Methylomic markers of persistent childhood asthma: a longitudinal study of asthma-discordant monozygotic twins.
Mill et al., London, United Kingdom. In Clin Epigenetics, 2014
The top-ranked nominally significant DMP associated with persisting asthma is located in the vicinity of the HLX gene, which has been previously implicated in childhood asthma.
MBD2 regulates TH17 differentiation and experimental autoimmune encephalomyelitis by controlling the homeostasis of T-bet/Hlx axis.
Wang et al., Wuhan, China. In J Autoimmun, 2014
Here we demonstrated that methyl-CpG-binding domain protein 2 (MBD2), an epigenetic regulator, controls autoimmunity and EAE through T-bet/Hlx.
The H2.0-like homeobox transcription factor modulates yolk sac vascular remodeling in mouse embryos.
Jones et al., New Haven, United States. In Arterioscler Thromb Vasc Biol, 2014
OBJECTIVE: The H2.0-like homeobox transcription factor (HLX) plays an essential role in visceral organogenesis in mice and has been shown to regulate angiogenic sprouting in vitro and in zebrafish embryos.
TH1/TH2 cell differentiation and molecular signals.
Sun et al., Shanghai, China. In Adv Exp Med Biol, 2013
There are many other transcription factors, such as RUNX family proteins, IRF4, Dec2, Gfi1, Hlx, and JunB that can impair TH1/TH2 cells differentiation.
H2.0-like homeobox regulates early hematopoiesis and promotes acute myeloid leukemia.
Steidl et al., United States. In Cancer Cell, 2012
This study identifies HLX as a key regulator in immature hematopoietic and leukemia cells and as a prognostic marker and therapeutic target in acute myeloid leukemia.
Functional polymorphisms in TBX21 and HLX are associated with development and prognosis of Graves' disease.
Iwatani et al., Ōsaka, Japan. In Autoimmunity, 2012
a functional polymorphism in HLX in combination with the TBX21 polymorphism is also associated with the prognosis of Graves' disease.
Over-expression of Hlx homeobox gene in DC2.4 dendritic cell enhances its maturation and antigen presentation.
Xu et al., Zhenjiang, China. In Cell Immunol, 2012
Results shown that over-expressed Hlx in DC2.4 up-regulated the transcription and expression of IFN-gamma, increased the expression of maturation makers including CD40, CD80, CD86, MHC-I and MHC-II
TBX21 and HLX1 polymorphisms influence cytokine secretion at birth.
Schaub et al., München, Germany. In Plos One, 2011
This study investigated the influence of TBX21 and HLX1 single nucleotide polymorphisms (SNPs), which have previously been shown to be associated with asthma, on T(H)1/T(H)2 lineage cytokines at birth.
[Functional study of transcription factor Hlx modified dendritic cell line DC2.4].
Xu et al., Zhenjiang, China. In Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi, 2011
Transient over-expression of Hlx in DC2.4 promotes DC2.4 maturation and up-regulates IL-12, IL-10 and TGF-beta expression. H1x modified DC2.4 cells seem to function as regulatory dendritic cells
Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.
Höfer et al., Berlin, Germany. In Immunity, 2009
This late expression of T-bet, accompanied by the upregulation of the transcription factors Runx3 and Hlx, was required to imprint the Th cell for interferon-gamma re-expression.
Hlx is induced by and genetically interacts with T-bet to promote heritable T(H)1 gene induction.
Reiner et al., Philadelphia, United States. In Nat Immunol, 2002
Optimal induction of interferon-gamma (IFN-gamma) expression required genetic interaction between T-bet and its target, the homeoprotein Hlx.
Life and death in the placenta: new peptides and genes regulating human syncytiotrophoblast and extravillous cytotrophoblast lineage formation and renewal.
Li et al., Edmonton, Canada. In Curr Protein Pept Sci, 2001
The homeobox genes DLX4, HB24, MSX2 and MOX2 also likely play a role in development at the epithelial-mesenchymal boundary.
Molecular basis of T-cell differentiation.
Davis et al., New Haven, United States. In Cold Spring Harb Symp Quant Biol, 1998
In the first, selective expression of transcription factors such as GATA3 in Th2 cells and the homeobox gene HLX in Th1 cells occurs, and appears in both cases to play a causal role.
[A family with X-linked hydrocephalus resulting from mutations in the neural cell adhesion molecule L1].
Matsukura et al., Nichinan, Japan. In Rinsho Shinkeigaku, 1996
Our results indicate that HLX is caused by the mutations in the gene for neural L1CAM in our family.
Potential roles for two human homeodomain containing proteins in the proliferation and differentiation of human hematopoietic progenitors.
Deguchi et al., Bethesda, United States. In Leuk Lymphoma, 1993
Two human homeobox genes, HB9 and HLX, are expressed in hematopoietic progenitors and activated lymphocytes.
Deregulation of a homeobox gene, HOX11, by the t(10;14) in T cell leukemia.
Korsmeyer et al., Saint Louis, United States. In Science, 1991
Characterization of this gene from chromosome segment 10q24 revealed it to be a new homeobox, HOX11.
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