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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Major histocompatibility complex, class I, G

HLA-G, MHC class I antigen, B2-microglobulin
HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: MHC, CAN, HAD, IL-10, CD8
Papers on HLA-G
Adipose-derived mesenchymal stem cells modulate the immune response in chronic experimental autoimmune encephalomyelitis model.
Abdel Hamid et al., Az Zaqāzīq, Egypt. In Iubmb Life, Feb 2016
The important finding was that human HLA-G gene was significantly expressed in lymph nodes and brains of rats treated with ASCs.
Diagnostic significance of soluble human leukocyte antigen-G for gastric cancer.
Yan et al., Linhai, China. In Hum Immunol, Feb 2016
UNASSIGNED: Human leukocyte antigen-G (HLA-G) is a novel tumor marker.
Differential expression of HLA-G and ILT-2 receptor in human tuberculosis: Localized versus disseminated disease.
Kanga et al., New Delhi, India. In Hum Immunol, Feb 2016
UNASSIGNED: Human leukocyte antigen-G (HLA-G) is an anti-inflammatory and immunosuppressive molecule that can modulate immune cell activation.
Non classical human leukocyte antigen (HLA-G, HLA-E, and HLA-F) in coronary artery disease.
Rizzo et al., Tunisia. In Hum Immunol, Feb 2016
METHODS: Different polymorphisms in HLA-G (14-bp Insertion/Deletion, +3142C/G), HLA-E (HLA-E∗01:01/01:03 A/G), HLA-F (HLA-F∗01:02 T/C, 01:03 C/T, 01:04 A/C) genes were typed using different laboratory techniques in a cohort of 89 CAD patients and 84 controls.
Human leukocyte antigen-G polymorphisms association with cancer post-heart transplantation.
Delgado et al., Toronto, Canada. In Hum Immunol, Feb 2016
Human leukocyte antigen (HLA)-G is a molecule that inhibits the immune system and it is utilized by malignant cells that express HLA-G to hide from the immune system.
Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.
Groettrup et al., Konstanz, Germany. In Sci Rep, Dec 2015
Apart from its role in MHC class I antigen processing, the immunoproteasome has recently been implicated in the modulation of T helper cell differentiation under polarizing conditions in vitro and in the pathogenesis of autoimmune diseases in vivo.
Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction.
Colucci et al., Cambridge, United Kingdom. In Immunol Rev, Sep 2015
Invading placental trophoblast cells express human leukocyte antigen class I ligands (HLA-E, HLA-G, and HLA-C) for receptors on maternal uterine natural killer (NK) and myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunoglobulin receptor (KIR).
PreImplantation Factor (PIF*) endogenously prevents preeclampsia: Promotes trophoblast invasion and reduces oxidative stress.
Paidas et al., Cherry Hill, United States. In J Reprod Immunol, Aug 2015
We reported that 1. PIF promotes implantation, endometrium receptivity, trophoblast invasion and increases pro-tolerance trophoblastic HLA-G expression and, 2. PIF protects against oxidative stress and protein misfolding, interacting with specific targets in embryo, 3. PIF regulates systemic immunity to reduce oxidative stress.
Novel aspects of human infertility: the role of the male factor.
Kurpisz et al., L'viv, Ukraine. In Postepy Hig Med Dosw (online), 2014
Particularly, molecular aspects of HLA-G and HLA-C in developmental biology are raised.
[HLA-G: from feto-maternal tolerance to organ acceptance].
Carosella, In Bull Acad Natl Med, 2014
HLA-G is a nonclassical class Imolecule that differs from classical antigens by its restricted expression, very low polymorphism, expression of 7 different protein isoforms, and immune tolerance-inducing activity.
Clinical relevance of sHLA-G-mediated with better graft acceptance in early posttransplantation.
Li et al., Beijing, China. In Transplant Proc, 2012
Suggest that HLA-G participates in the induction of immunologic tolerance in early kidney posttransplantation period.
HLA-G1 and HLA-G5 active dimers are present in malignant cells and effusions: the influence of the tumor microenvironment.
Menier et al., Paris, France. In Eur J Immunol, 2012
HLA-G1 and its soluble counterpart HLA-G5 are present as dimers in cancer.
A novel bridge between oxidative stress and immunity: the interaction between hydrogen peroxide and human leukocyte antigen G in placental trophoblasts during preeclampsia.
Sun et al., Nanjing, China. In Am J Obstet Gynecol, 2012
High levels of hydrogen peroxide can down-regulate HLA-G expression in trophoblasts during preeclampsia and trophoblasts expressing HLA-G are vulnerable to oxidative stress.
Heparin increases HLA-G levels in primary antiphospholipid syndrome.
Pereira et al., São Paulo, Brazil. In Clin Dev Immunol, 2011
serum levels are increased in primary antiphospholipid syndrome patients
Expression of human leukocyte antigen G is associated with prognosis in nasopharyngeal carcinoma.
Zeng et al., Guangzhou, China. In Int J Biol Sci, 2011
Results suggest that HLA-G is an independent biomarker for NPC prognosis, and HLA-G might contribute to NPC progression, which might jointly regulate immune surveillance in NPC together with macrophages and IL-10.
Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1.
Ahn et al., Seoul, South Korea. In Nat Immunol, 2011
Our findings identify a previously unknown viral miRNA-based CTL-evasion mechanism that targets a key step in the MHC class I antigen-processing pathway.
MHC class I antigen presentation: learning from viral evasion strategies.
Bouvier et al., Saint Louis, United States. In Nat Rev Immunol, 2009
However, in turn, viruses have evolved elegant strategies to inhibit various stages of the MHC class I antigen presentation pathway and prevent the display of viral peptides.
Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway.
Shastri et al., Berkeley, United States. In Immunity, 2006
Intracellular proteins are degraded in the antigen processing pathway to generate peptide-loaded MHC I complexes (pMHC I) for immune surveillance.
A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation.
Neefjes et al., Amsterdam, Netherlands. In Immunity, 2004
Intracellular proteins are degraded by the proteasome, and resulting peptides surviving cytoplasmic peptidase activity can be presented by MHC class I molecules.
The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation.
Rock et al., Worcester, United States. In Immunity, 2003
Most antigenic peptides presented on MHC class I molecules are generated by proteasomes during protein breakdown.
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