Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction.
Cambridge, United Kingdom. In Immunol Rev, Sep 2015
Invading placental trophoblast cells express human leukocyte antigen class I ligands (HLA-E, HLA-G, and HLA-C) for receptors on maternal uterine natural killer (NK) and myelomonocytic cells, CD94/NKG2, leukocyte immunoglobulin-like receptor (LILR), and killer immunoglobulin receptor (KIR).
[HLA-G: from feto-maternal tolerance to organ acceptance].
In Bull Acad Natl Med, 2014
HLA-G is a nonclassical class Imolecule that differs from classical antigens by its restricted expression, very low polymorphism, expression of 7 different protein isoforms, and immune tolerance-inducing activity.