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Major histocompatibility complex, class I, F

This gene belongs to the HLA class I heavy chain paralogues. It encodes a non-classical heavy chain that forms a heterodimer with a beta-2 microglobulin light chain, with the heavy chain anchored in the membrane. Unlike most other HLA heavy chains, this molecule is localized in the endoplasmic reticulum and Golgi apparatus, with a small amount present at the cell surface in some cell types. It contains a divergent peptide-binding groove, and is thought to bind a restricted subset of peptides for immune presentation. This gene exhibits few polymorphisms. Multiple transcript variants encoding different isoforms have been found for this gene. These variants lack a coding exon found in transcripts from other HLA paralogues due to an altered splice acceptor site, resulting in a shorter cytoplasmic domain. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: MHC, HLA-A, HLA-G, HLA-B, ACID
Papers on HLA-F
Non classical human leukocyte antigen (HLA-G, HLA-E, and HLA-F) in coronary artery disease.
Rizzo et al., Tunisia. In Hum Immunol, Feb 2016
Because of the inflammatory nature of CAD, we investigated the human leukocyte antigen (HLA)-G, HLA-E, and HLA-F genetic polymorphisms within CAD patients and evaluated their potential association with this disease in Tunisian population.
The ubiquitin-like modifier FAT10 in antigen processing and antimicrobial defense.
Groettrup et al., Konstanz, Germany. In Mol Immunol, Dec 2015
The ubiquitin-like modifier (ULM) HLA-F adjacent transcript 10 (FAT10) is encoded in the MHC locus, is up-regulated during dendritic cell maturation, is highly expressed in lymphoid tissues, and strongly induced by interferon (IFN)-γ and tumor necrosis factor (TNF)-α.
The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection.
Basler et al., Konstanz, Germany. In J Immunol, Dec 2015
HLA-F adjacent transcript 10 (FAT10) is a cytokine-inducible ubiquitin-like modifier that is highly expressed in the thymus and directly targets FAT10-conjugated proteins for degradation by the proteasome.
Clinical implication of human leukocyte antigen (HLA)-F expression in breast cancer.
Natsugoe et al., Kagoshima, Japan. In Pathol Int, Nov 2015
HLA-F expression was immunohistochemically examined and the association between clinical parameters and HLA-F expression was analyzed.
Serum antibodies to HLA-E, HLA-F and HLA-G in patients with SLE during disease flares: Clinical relevance of HLA-F autoantibodies.
Biesen et al., Los Angeles, United States. In Clin Exp Immunol, Nov 2015
The objective was to evaluate the association of HLA-Ib (HLA-E, HLA-F and HLA-G) antibodies to the disease activity of SLE.
Monoclonal antibodies to HLA-E bind epitopes carried by unfolded β2 m-free heavy chains.
Giacomini et al., Roma, Italy. In Eur J Immunol, Aug 2015
They contain at least one HLA-E-specific residue that cannot be replaced by single substitutions with polymorphic HLA-A, HLA-B, HLA-C, HLA-F, and HLA-G residues.
Expression patterns of immune-associated genes in external genital and perianal warts treated with sinecatechins.
Tyring et al., Houston, United States. In Viral Immunol, May 2015
In the antigen processing array, HLA-A, HLA-C, HLA-DMA, HLA-DMB, HLA-F, PSMA5, PSMB8, and PSMB9 were differentially downregulated.
Human leukocyte antigen (HLA)-E and HLA-F expression in gastric cancer.
Natsugoe et al., Kagoshima, Japan. In Anticancer Res, Apr 2015
Human leukocyte antigen (HLA)-E and HLA-F are classified as non-classical HLA class Ib antigens.
Conjugation of the ubiquitin activating enzyme UBE1 with the ubiquitin-like modifier FAT10 targets it for proteasomal degradation.
Aichem et al., Kreuzlingen, Switzerland. In Plos One, 2014
The ubiquitin-like modifier HLA-F adjacent transcript 10 (FAT10) directly targets its substrates for proteasomal degradation by becoming covalently attached via its C-terminal diglycine motif to internal lysine residues of its substrate proteins.
Infection of human amniotic and endothelial cells by Japanese encephalitis virus: Increased expression of HLA-F.
Manjunath et al., Bengaluru, India. In Virology, 2014
Productive infection of human amniotic and endothelial cell lines with Japanese encephalitis virus (JEV) was established leading to the induction of NFκB and HLA-F, a non-classical MHC molecule.
Impact of human leukocyte antigen molecules E, F, and G on the outcome of transplantation.
Lozano et al., Bogotá, Colombia. In Transplant Proc, 2014
There were no significant associations between HLA-F and clinical outcomes in any of the studies.
Mammalian non-classical major histocompatibility complex I and its receptors: Important contexts of gene, evolution, and immunity.
Chattopadhyay et al., Bhubaneshwar, India. In Indian J Hum Genet, 2014
The evolutionary conserved, less-polymorphic, nonclassical major histocompatibility complex (MHC) class I molecules: Qa-1 and its human homologue human leukocyte antigen-E (HLA-E) along with HLA-F, G and H cross-talk with the T-cell receptors and also interact with natural killer T-cells and other lymphocytes.
HLA Class Ib Molecules and Immune Cells in Pregnancy and Preeclampsia.
Hviid et al., Roskilde, Denmark. In Front Immunol, 2013
The HLA-G molecule is primarily expressed by the extravillous trophoblast cells lining the placenta together with the two other HLA class Ib molecules, HLA-E and HLA-F.
Role of non-classical MHC class I molecules in cancer immunosuppression.
Guerrero-Setas et al., Spain. In Oncoimmunology, 2013
However, while the presence of HLA-G and HLA-E has been recently correlated with poor clinical outcome, information on the clinicopathological significance of HLA-F is limited.
Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease.
Sawalha et al., Ann Arbor, United States. In Nat Genet, 2013
Three additional independent genetic associations within PSORS1C1 (rs12525170: OR = 3.01, P = 3.01 × 10(-26)), upstream of HLA-F-AS1 (rs114854070: OR = 1.95,
HLA-F is a surface marker on activated lymphocytes.
Geraghty et al., Seattle, United States. In Eur J Immunol, 2010
surface marker on activated lymphocytes
HLA-F complex without peptide binds to MHC class I protein in the open conformer form.
Geraghty et al., Seattle, United States. In J Immunol, 2010
These data suggest that HLA-F is expressed independently of peptide and that a physical interaction specific to MHC-I HC plays a role in the function of MHC-I HC expression in activated lymphocytes.
Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48.
Moffett et al., Cambridge, United Kingdom. In Hum Reprod, 2008
the role of NKG2D and 2B4 is not focussed on trophoblast recognition in normal pregnancy, but is more likely involved in cross-talk among maternal cells of the placental bed
HLA-driven convergence of HIV-1 viral subtypes B and F toward the adaptation to immune responses in human populations.
Salomón et al., Buenos Aires, Argentina. In Plos One, 2007
Across HIV Gag protein, the rise of polymorphisms from independent origin during the last twenty years of epidemic was related to an association with an HLA allele accumulated in one of either B or F subtypes
HLA-G, -E and -F: allelism, function and evolution.
Arnaiz-Villena et al., Madrid, Spain. In Transpl Immunol, 2006
strong positive directional selection is acting for maintaining the observed low polymorphism on HLA-E, -F and -G loci
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