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Major histocompatibility complex, class II, DR alpha

HLA-DRA, histocompatibility antigen HLA-DR
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: DRA, MHC, CAN, IFN-gamma, CIITA
Papers on HLA-DRA
Genetic variants associated with drugs-induced immediate hypersensitivity reactions: a PRISMA-compliant systematic review.
Task force “Genetic predictors of drug hypersensitivity” of the European Network on Drug Allergy (ENDA) of EAACI. et al., Vandœuvre-lès-Nancy, France. In Allergy, Jan 2016
Genes involved in IR to betalactams belonged to HLA type 2 antigen processing, IgE-production, atopy and inflammation, including 4 genes validated by replications, HLA-DRA, ILR4, NOD2 and LGALS3.
Novel 6p21.3 Risk Haplotype Predisposes to Acute Coronary Syndrome.
Lokki et al., Helsinki, Finland. In Circ Cardiovasc Genet, Jan 2016
We found a risk haplotype for the disease containing SNPs from BTNL2 and HLA-DRA genes and the HLA-DRB1*01 allele.
Bioinformatic analysis of potential candidates for therapy of inflammatory bowel disease.
Xu et al., Changchun, China. In Eur Rev Med Pharmacol Sci, Nov 2015
From the PPI network and module, DEGs of mitogen-activated protein kinase 3 (MAPK3), N-myc downstream regulated 1 (NDRG1) and major histocompatibility complex, class II, DR alpha (HLA-DRA) have high degree.
FOXP1 suppresses immune response signatures and MHC class II expression in activated B-cell-like diffuse large B-cell lymphomas.
Banham et al., Oxford, United Kingdom. In Leukemia, Nov 2015
In an independent primary DLBCL microarray data set, multiple MHC II genes, including human leukocyte antigen DR alpha chain (HLA-DRA), were inversely correlated with FOXP1 transcript expression (P<0.05).
Murine heart gene expression during acute Chagasic myocarditis.
Parra-Henao et al., Denver, United States. In Genom Data, Jun 2015
The output of the genes expression suggests differences in involvement of protein kinase B (AKT), NCAM1, HLA-DRA, and ubiquitin C genes networks.
Knowledge-based analysis of genetic associations of rheumatoid arthritis to inform studies searching for pleiotropic genes: a literature review and network analysis.
Rao et al., Beijing, China. In Arthritis Res Ther, 2014
RESULTS: In total, we extracted 116 potential functional pleiotropic genes for RA and eight other diseases, including five hub pleiotropic genes, BTNL2, HLA-DRA, NOTCH4, TNXB, and C6orf10, where BTNL2, NOTCH4, and C6orf10 are novel pleiotropic genes identified by our analysis.
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese.
Wang et al., Beijing, China. In Sci Rep, 2014
Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4.
Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease.
Wu et al., Taipei, Taiwan. In Parkinsonism Relat Disord, 2012
In this study observe no association between this single nucleotide polymorphism of HLA-DRA and Parkinson's disease in a Taiwanese population.
Absent in Melanoma 2 (AIM2) is an important mediator of interferon-dependent and -independent HLA-DRA and HLA-DRB gene expression in colorectal cancers.
Dihlmann et al., Heidelberg, Germany. In Oncogene, 2012
small interfering RNA-mediated knock-down of AIM2 resulted in reduced expression of HLA-DRA, HLA-DRB and CIITA in IFN-gamma-treated cells
HLA-DRA polymorphisms associated with risk of nasal polyposis in asthmatic patients.
Shin et al., Seoul, South Korea. In Am J Rhinol Allergy, 2012
genetic polymorphism is associated with the presence of nasal polyposis in asthmatic patients
Conformational analysis of the ΜΒΡ83-99 (Phe91) and ΜΒΡ83-99 (Tyr91) peptide analogues and study of their interactions with the HLA-DR2 and human TCR receptors by using molecular dynamics.
Golič Grdadolnik et al., Athens, Greece. In J Comput Aided Mol Des, 2011
Molecular Dynamics simulations of the MuBetaRho 83-99 (Phe91) and MuBetaRho 83-99 (Tyr91) peptide analogues in complex with HLA-DR2 (DRA, DRB1*1501) and T-cell receptors were performed.
Evidence for more than one Parkinson's disease-associated variant within the HLA region.
Payami et al., Albany, United States. In Plos One, 2010
SNP1 is a Parkinson's disease-associated variant in HLA-DRA and is associated with HLA-DRA, DRB5 and DQA2 gene expression.
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.
Payami et al., Albany, United States. In Nat Genet, 2010
The association peak we found was at rs3129882, a noncoding variant in HLA-DRA.
Risk alleles for multiple sclerosis identified by a genomewide study.
Hauser et al., Boston, United States. In N Engl J Med, 2007
Alleles of IL2RA and IL7RA and those in the HLA locus are identified as heritable risk factors for multiple sclerosis.
CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter.
Boss et al., Atlanta, United States. In Nat Immunol, 2001
Acetylation and deacetylation of histones H3 and H4 at the HLA-DRA promoter were found to occur during a time-course that depended on CIITA expression and binding.
New revelations in susceptibility to autoimmune thyroiditis by the use of H2 and HLA class II transgenic models.
David et al., Detroit, United States. In Int Rev Immunol, 1999
Susceptibility was transferred by H2 class II transgenes to a resistant haplotype and by HLA-DRA/DRB1*0301 (DR3) transgene into class II-negative Ab0 mice.
Endothelial activation and development of coronary artery disease in transplanted human hearts.
Faulk et al., Indianapolis, United States. In Jama, 1997
METHODS: Immunocytochemistry was performed on serial endomyocardial biopsy specimens to evaluate endothelial activation markers (intercellular adhesion molecule-1 and histocompatibility antigen HLA-DR) in arteries and arterioles.
Transcriptional regulation of HLA-DRA gene.
Peterlin, San Francisco, United States. In Res Immunol, 1991
Transcriptional regulation of class II genes is complex.
Transcriptional regulation of the HLA-DRA gene.
Ting et al., Chapel Hill, United States. In Crit Rev Immunol, 1990
Class II Major Histocompatibility Complex (MHC) products are essential initiators of cellular immune responses.
Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X.
Mach et al., Genève, Switzerland. In Cell, 1988
We have identified three proteins binding to specific segments of the HLA-DRA promoter, two of which interact to form the predominant DNA-protein complex observed.
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