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Major histocompatibility complex, class II, DQ beta 1

HLA-DQB1, DC1, DQB1*0501, DCI
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011] (from NCBI)
Top mentioned proteins: DRB1, HAD, AGE, CAN, HLA-A
Papers using HLA-DQB1 antibodies
Granzymes in disease: bench to bedside.
Reitsma Pieter H., In PLoS ONE, 2009
... incubated in the presence or absence of 200 µM of the serine protease inhibitor 3,4-dichloroisocoumarin (DCI; Santa Cruz Biotechnology Inc, Santa Cruz, CA) ...
The brain-specific double-stranded RNA-binding protein Staufen2 is required for dendritic spine morphogenesis
Kiebler Michael A. et al., In The Journal of Cell Biology, 2003
... used in this study are available upon request.pEYFP-N1
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
Colombo Emanuela et al., In The Journal of Cell Biology, 1997
... RNA was extracted from MEFs with an RNAeasy MiniKit (QIAGEN), including a DNase treatment before ...
Papers on HLA-DQB1
The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population.
Lehotský et al., Bratislava, Slovakia. In Neurol Res, Feb 2016
HLA-DRB1 and HLA-DQB1 allele groups were genotyped using a polymerase chain reaction with sequence-specific primers.
Common coding variants in the HLA-DQB1 region confer susceptibility to age-related macular degeneration.
Shen et al., Oakland, United States. In Eur J Hum Genet, Feb 2016
P=1.4 × 10(-11)) corresponding to amino-acid changes at position 66 and 67 in HLA-DQB1, respectively, and the DQB1*02 classical HLA allele (OR=1.22;
7/8 and 9/10 or Better High Resolution Match Rate for the Be The Match® Unrelated Donor Registry.
Dehn et al., Colombia. In Biol Blood Marrow Transplant, Jan 2016
Extending criteria to identify a 9/10 match (included HLA-DQB1) showed the 9/10 absolute match rate decreased between 14-21% from the 7/8 match rate for the non-WH groups.
Role of Genetic Polymorphisms in Predicting Delayed Cerebral Ischemia and Radiographic Vasospasm After Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis.
Du et al., Boston, United States. In World Neurosurg, Oct 2015
OBJECTIVE: The pathophysiology on cerebral vasospasm and delayed cerebral ischemia (DCI) remains poorly understood.
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.
Raychaudhuri et al., Boston, United States. In Nat Genet, Aug 2015
The three positions together explained 90% of the phenotypic variance in the HLA-DRB1-HLA-DQA1-HLA-DQB1 locus.
The Relationship of HLA-DQ Alleles with Tuberculosis Risk: A Meta-analysis.
He et al., Nanning, China. In Lung, Aug 2015
No significant association with TB risk was found in any HLA-DQA1 allele or in other HLA-DQB1 alleles.
Reflections on inositol(s) for PCOS therapy: steps toward success.
Unfer et al., In Gynecol Endocrinol, Jul 2015
Despite their similarities, Myo-inositol (MI) and d-chiro-inositol (DCI) play different roles in PCOS etiology and therapy.
Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease.
de Bakker et al., Groningen, Netherlands. In Nat Genet, Jun 2015
Although dietary gluten is the trigger for celiac disease, risk is strongly influenced by genetic variation in the major histocompatibility complex (MHC) region.
Functional significance of the sex chromosomes during spermatogenesis.
Namekawa et al., Cincinnati, United States. In Reproduction, Jun 2015
The unique gene contents and genomic structures of the sex chromosomes reflect their strategies to express genes at various stages of spermatogenesis and reveal the driving forces that shape their evolution.Free Chinese abstract: A Chinese translation of this abstract is freely available at Japanese abstract: A Japanese translation of this abstract is freely available at
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese.
Wang et al., Beijing, China. In Sci Rep, 2014
Of these pSS candidates, 14 genes had been reported to be associated with any of pSS, RA, and SLE, including STAT4, GTF2I, HLA-DPB1, HLA-DRB1, PTTG1, HLA-DQB1, MBL2, TAP2, CFLAR, NFKBIE, HLA-DRA, APOM, HLA-DQA2 and NOTCH4.
Analysis of HLA-DQB1 allele polymorphisms in Uyghur women with cervical cancer.
Niyazi et al., Ürümqi, China. In Genet Mol Res, 2014
We investigated the correlation between polymorphisms of the HLA-DQB1 allele and cervical cancer in Xinjiang Uyghur women.
Variation at HLA-DRB1 is associated with resistance to enteric fever.
Khor et al., Thành phố Hồ Chí Minh, Vietnam. In Nat Genet, 2014
We observed strong association at rs7765379 (odds ratio (OR) for the minor allele = 0.18, P = 4.5 × 10(-10)), a marker mapping to the HLA class II region, in proximity to HLA-DQB1 and HLA-DRB1.
Human Leukocyte Antigen DQB1 (HLA-DQB1) Polymorphisms and the Risk for Guillain-Barré Syndrome: A Systematic Review and Meta-Analysis.
Hou et al., Shanghai, China. In Plos One, 2014
There is no consensus regarding reported associations between human leukocyte antigen DQB1 (HLA-DQB1) polymorphisms and the risk for developing GBS.
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens.
Gharavi et al., New York City, United States. In Nat Genet, 2014
We identified six new genome-wide significant associations, four in ITGAM-ITGAX, VAV3 and CARD9 and two new independent signals at HLA-DQB1 and DEFA.
Association of variants in HLA-DQA1-DQB1, PTPN22, INS, and CTLA4 with GAD autoantibodies and insulin secretion in nondiabetic adults of the Botnia Prospective Study.
Tuomi et al., Helsinki, Finland. In Eur J Endocrinol, 2012
In nondiabetic adults, HLA-DQ2.5/HLA-DQ8 and PTPN22 CT/TT genotypes were associated with glutamic acid decarboxylase autoantibodies.
HLA-DQ typing in the diagnostic algorithm of celiac disease.
Villanacci et al., Siena, Italy. In Rev Esp Enferm Dig, 2012
In patients with celiac disease (CD), 64% had DQ2 heterodimer (alpha5beta2), 13.5% DQ8 heterodimer without DQ2, 21.4% only beta2 chain and 1.1% DQ2 alpha5 chain. Presence of alpha5 chain did not predispose to CD. DQB1*02 allele was more frequent than in o
HLA-DRB1-DQB1 haplotypes confer susceptibility and resistance to multiple sclerosis in Sardinia.
Marrosu et al., Cagliari, Italy. In Plos One, 2011
association of specific, independent DRB1*-DQB1* haplotypes confers susceptibility or resistance to multiple sclerosis
Influence of HLA DQ 2/8 genotypes in predisposing type 1 diabetes in siblings of a Saudi family with paternally inherited chromosomal translocations.
Cherian, Cochin, India. In J Pediatr Endocrinol Metab, 2011
Diabetic children were found to have HLA genotype DQ 2/8, whereas the father and the youngest daughter, both carrying two sets of balanced translocations as well as the protective HLA genotype DQ6, were free of diabetes.
Thiamine-responsive megaloblastic anemia syndrome: a novel mutation.
Onder et al., Ankara, Turkey. In Genet Couns, 2011
Thiamine-responsive megaloblastic anemia syndrome is an autosomal recessive disorder characterized by diabetes mellitus, megaloblastic anemia and sensorineural hearing loss due to mutations in SLC 19A.
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