GoPubMed Proteins lists recent and important papers and reviews for
proteins. Page last changed on 19 Dec 2016.
Major histocompatibility complex, class I, B
HLA-B, HLA-B27, B-12
HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008] (from
NCBI)
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HLA-A, CAN, HAD, AGE, DRB1
Papers using
HLA-B
antibodies
Gene expression profiling reveals a downregulation in immune-associated genes in patients with AS
Supplier
In Nature immunology, 2009
... Inflammatory disease in HLA-B27 transgenic rats ...
Inhibition of tumor angiogenesis in vivo by monoclonal antibody targeted to domain 5 of high molecular weight kininogen
Supplier
In Arthritis Research & Therapy, 2003
... HLA-B27 transgenic male rats were purchased ...
Expression of estrogen receptor related protein (p29) and estradiol binding in human arthritic synovium
Supplier
In Arthritis Research & Therapy, 1994
... Male HLA-B27 transgenic rats were obtained from ...
Papers on
HLA-B
Actinic Prurigo in Singaporean Chinese: A Positive Association with HLA-DRB1*03:01.
New
Singapore, Singapore. In Photochem Photobiol, Feb 2016
All patients did not have a family history of AP and none had mucosal involvement, as such these clinical features differed from Caucasian AP patients.
Interactions of the Immune System with Skin and Bone Tissue in Psoriatic Arthritis: A Comprehensive Review.
Review
New
Sacramento, United States. In Clin Rev Allergy Immunol, Feb 2016
The soluble and cellular mediators of these closely related diseases are being elucidated through genetic approaches such as genome-wide association studies (GWAS), as well as animal and molecular models.
Safety and efficacy of oral febuxostat for treatment of HLA-B*5801-negative gout: a randomized, open-label, multicentre, allopurinol-controlled study.
New
Taipei, Taiwan. In Scand J Rheumatol, Feb 2016
OBJECTIVES: This phase IIIB study compared the efficacy and safety of febuxostat and allopurinol in gout patients with or without tophi who were HLA-B*5801 negative.
High risk HLA alleles for severe acute graft-versus-host disease and mortality in unrelated donor bone marrow transplantation.
New
Cần Thơ, Vietnam. In Haematologica, Feb 2016
Using unbiased searches of patient and donor HLA alleles, patient and/or donor HLA-B*51:01 (patient: HR, 137; P<0.001, donor: HR, 1.35; P<0.001) and patient HLA-C*14:02 (HR, 1.35; P<0.001) were significantly associated with an increased risk of severe acute graft-versus-host disease.
Fecal calprotectin is associated with disease activity in patients with ankylosing spondylitis.
New
In Bosn J Basic Med Sci, Feb 2016
Serum calprotectin levels are associated with certain inflammatory diseases such as rheumatoid arthritis, systemic lupus erythematosus and inflammatory bowel disease.
Gut inflammation and microbiome in spondyloarthritis.
Review
New
Vellore, India. In Rheumatol Int, Jan 2016
Bowel inflammation is common in SpA, which may be classified as acute or chronic.
Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences.
New
Kumamoto, Japan. In Mbio, Dec 2015
However, the effects of HLA polymorphisms on recognition by primary Nef isolates remain elusive, as do the specific Nef regions responsible for downregulation of HLA-A versus HLA-B.
Epidermal necrolysis: 60 years of errors and advances.
Review
New
Singapore, Singapore. In Br J Dermatol, Nov 2015
HLA-B*1502 with carbamazepine-induced TEN) and understanding of the pathogenic roles of drug-specific cytotoxic T cells and granulysin.
Uveitis in Spondyloarthritis: An Overview.
Review
New
Prato, Italy. In J Rheumatol Suppl, Nov 2015
Autoimmune anterior uveitis (AU) accounts for at least half of the cases of noninfectious uveitis, and similarly to spondyloarthritis (SpA), its occurrence is related to HLA-B27 positivity.
Class II HLA interactions modulate genetic risk for multiple sclerosis.
New
Impact
In Nat Genet, Oct 2015
Among new and previously identified class II risk alleles (HLA-DRB1*15:01, HLA-DRB1*13:03, HLA-DRB1*03:01, HLA-DRB1*08:01 and HLA-DQB1*03:02) and class I protective alleles (HLA-A*02:01, HLA-B*44:02, HLA-B*38:01 and HLA-B*55:01), we find evidence for two interactions involving pairs of class II alleles: HLA-DQA1*01:01-HLA-DRB1*15:01 and HLA-DQB1*03:01-HLA-DQB1*03:02.
The involvement of the spine in psoriatic arthritis.
Review
New
Bochum, Germany. In Clin Exp Rheumatol, Sep 2015
In addition, clinical examination of patients initially diagnosed as PsA due to peripheral symptoms and skin lesions may also show inflammation in the axial skeleton causing inflammatory back pain, stiffness and changes on imaging including sacroiliitis, spondylitis and syndesmophyte formation, similar to what is known from ankylosing spondylitis (AS), the prototype of SpA.
Construction of a population-specific HLA imputation reference panel and its application to Graves' disease risk in Japanese.
New
Impact
Tokyo, Japan. In Nat Genet, Jul 2015
We applied HLA imputation to genome-wide association study (GWAS) data for Graves' disease in Japanese (n = 9,003) and found that amino acid polymorphisms of multiple class I and class II HLA genes independently contribute to disease risk (HLA-DPB1, HLA-A, HLA-B and HLA-DRB1; P < 2.3 × 10(-6)), with the strongest impact at HLA-DPB1 (P = 1.6 × 10(-42)).
HLA-B27.
Review
Impact
Oxford, United Kingdom. In Annu Rev Immunol, 2014
Possession of the human leukocyte antigen (HLA) class I molecule B27 is strongly associated with ankylosing spondylitis (AS), but the pathogenic role of HLA-B27 is unknown.
Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma.
Impact
Rochester, United States. In Nat Genet, 2014
In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10(-21)), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10(-10)), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10(-8)) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10(-13) and 3.63 × 10(-11), respectively).
HLA match likelihoods for hematopoietic stem-cell grafts in the U.S. registry.
Impact
Latvia. In N Engl J Med, 2014
However, many patients will not have an optimal adult donor--that is, a donor who is matched at high resolution at HLA-A, HLA-B, HLA-C, and HLA-DRB1.
Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules.
GeneRIF
Roma, Italy. In J Biol Chem, 2012
Characterization of a proteasome and TAP-independent presentation of intracellular epitopes by HLA-B27 molecules.
Residue 81 confers a restricted C-terminal peptide binding motif in HLA-B*44:09.
GeneRIF
Hannover, Germany. In Immunogenetics, 2012
Data indicate that B*44:09-derived peptides are restricted predominantly to L (Leu) or F (Phe).
HLA-B may be more protective against HIV-1 than HLA-A because it resists negative regulatory factor (Nef) mediated down-regulation.
GeneRIF
Oxford, United Kingdom. In Proc Natl Acad Sci U S A, 2012
The relative resistance to Nef-mediated down-regulation by the cytoplasmic domains of HLA-B compared with HLA-A contributes to the better control of HIV-1 infection associated with HLA-B-restricted cytotoxic T lymphocytes.
TCR clonotypes modulate the protective effect of HLA class I molecules in HIV-1 infection.
Impact
GeneRIF
Boston, United States. In Nat Immunol, 2012
The data indicated that HLA-B*27- and HLA-B*57-restricted CD8+ T cells targeting the same epitopes in elite controllers and progressors were distinctly different, on the basis of potency and cross-reactivity of TCR recognition of HIV-1 and viral variants.
Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease.
GeneRIF
Curitiba, Brazil. In Plos One, 2011
Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease.
