histidine-rich protein 2
Aveiro, Portugal. In Expert Rev Proteomics, 2010
Gln-Gly cleavages are largely associated with PRP classes, while Tyr-Gly cleavages are related to histatin 1 and to the P-B peptide.
Testing of natural products and synthetic molecules aiming at new antimalarials.
Belo Horizonte, Brazil. In Curr Drug Targets, 2009
Other methodologies have proven to be more precise and allow mass screening of new compounds against PF blood stages, such as: (i) measuring the incorporation of radioactive hypoxanthine by the parasites; (ii) indirect colorimetric assays in which specific parasite enzyme activities, and histidine-rich protein II (HRP2) production are measured with the help of monoclonal antibodies; (iii) the beta-haematin formation, and; (iv) assays using green fluorescent protein (GFP) in gene-expressing parasites.