Phenotypic variability in human skin mast cells.
Berlin, Germany. In Exp Dermatol, Jan 2016
Pathophysiologically relevant key features were quantified and correlated: transcripts of c-kit, FcεRIα, FcεRIβ, FcεRIγ, histidine decarboxylase, tryptase, and chymase; surface expression of c-Kit, FcεRIα; activity of tryptase, and chymase; histamine content and release triggered by FcεRI and Ca(2+) ionophore.
L-histidine decarboxylase and Tourette's syndrome.
New Haven, United States. In N Engl J Med, 2010
identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis which points to its role in Tourette's syndrome and tics
Gastric endocrine cells: gene expression, processing, and targeting of active products.
Liverpool, United Kingdom. In Physiol Rev, 1996
Recent work indicates physiological regulation of the expression of genes encoding cytosolic enzymes such as histidine decarboxylase, which converts histidine to histamine, and of secretory granule transporters such as vesicular monoamine transporter type 2, which concentrates amines in secretory vesicles.