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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Intraflagellar transport 57 homolog

Hippi, IFT57, Hip-1 protein interactor
Top mentioned proteins: HIP1, huntingtin, Polaris, PrP, CAN
Papers on Hippi
Genome-wide rare copy number variations contribute to genetic risk for transposition of the great arteries.
Bassett et al., Toronto, Canada. In Int J Cardiol, Mar 2016
Established and novel candidate susceptibility genes identified included ACKR3, IFT57, ITGB8, KL, NF1, NKX1-2, RERE, SLC8A1, SOX18, and ULK1.
Chibby functions to preserve normal ciliary morphology through the regulation of intraflagellar transport in airway ciliated cells.
Takemaru et al., Stony Brook, United States. In Cell Cycle, Nov 2015
Furthermore, we show that only IFT-B components, including IFT20 and IFT57, but not IFT-A and Bardet-Biedl syndrome (BBS) proteins, amass with IFT88 in these distended tips in Cby-/- ciliated cells.
A novel function of Huntingtin in the cilium and retinal ciliopathy in Huntington's disease mice.
Trottier et al., Illkirch-Graffenstaden, France. In Neurobiol Dis, Aug 2015
In HD mice, photoreceptor cilia are abnormally elongated, have hyperacetylated alpha-tubulin and show mislocalization of the intraflagellar transport proteins IFT57 and IFT88.
Specific recycling receptors are targeted to the immune synapse by the intraflagellar transport system.
Baldari et al., Siena, Italy. In J Cell Sci, 2014
The IFT components IFT52 and IFT57 were found to act together with IFT20 to regulate TCR and TfR recycling.
A divergent calponin homology (NN-CH) domain defines a novel family: implications for evolution of ciliary IFT complex B proteins.
Pedersen et al., Copenhagen, Denmark. In Bioinformatics, 2014
Here, using profile-to-profile comparisons and structure modeling, we show that the yeast outer kinetochore components NDC80 and NUF2 share evolutionary ancestry with a novel protein family in mammals comprising, besides NDC80/HEC1 and NUF2, three Intraflagellar Transport (IFT) complex B subunits (IFT81, IFT57, CLUAP1) as well as six proteins with poorly defined function (FAM98A-C, CCDC22, CCDC93 and C14orf166).
Functional consequences of necdin nucleocytoplasmic localization.
Fainzilber et al., Israel. In Plos One, 2011
Integration of these interactions into a comprehensive network revealed a number of coherent interaction modules, including a cytoplasmic module connecting to necdin through huntingtin-associated protein 1 (Hap1), dynactin and hip-1 protein interactor (Hippi); a nuclear P53 and Creb-binding-protein (Crebbp) module, connecting through Crebbp and WW domain-containing transcription regulator protein 1 (Wwtr1); and a nucleocytoplasmic transport module, connecting through transportins 1 and 2. We validated the necdin-transportin1 interaction and characterized a sequence motif in necdin that modulates karyopherin interaction.
Regulation of RE1 protein silencing transcription factor (REST) expression by HIP1 protein interactor (HIPPI).
Bhattacharyya et al., Calcutta, India. In J Biol Chem, 2011
novel transcription regulatory mechanism of REST by HIPPI may contribute to the deregulation of transcription observed in the cell model of Huntington disease.
Negative regulation of ciliary length by ciliary male germ cell-associated kinase (Mak) is required for retinal photoreceptor survival.
Furukawa et al., Suita, Japan. In Proc Natl Acad Sci U S A, 2011
We observed accumulation of intraflagellar transport 88 (IFT88) and IFT57, expansion of kinesin family member 3A (Kif3a), and acetylated α-tubulin signals in the Mak-null photoreceptor cilia.
Genome wide gene expression regulation by HIP1 Protein Interactor, HIPPI: prediction and validation.
Bhattacharyya et al., Calcutta, India. In Bmc Genomics, 2010
HIPPI-P53 interaction was necessary for HIPPI mediated up-regulation of Caspase1 gene.
Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25.
Riddle et al., Vancouver, Canada. In Plos Genet, 2010
The interaction may be specific because daf-25 mutants have normally-localized OSM-9/TRPV4, TAX-4/CNGA1, CHE-2/IFT80, CHE-11/IFT140, CHE-13/IFT57, BBS-8, OSM-5/IFT88, and XBX-1/D2LIC in the cilia.
Intraflagellar transport proteins are essential for cilia formation and for planar cell polarity.
Sun et al., New Haven, United States. In J Am Soc Nephrol, 2010
IFT proteins play a conserved role in cilia formation and planar cell polarity in zebrafish
Intraflagellar transport is required for polarized recycling of the TCR/CD3 complex to the immune synapse.
Baldari et al., Siena, Italy. In Nat Cell Biol, 2009
Moreover, IFT20 was required for the inducible assembly of a complex with other IFT components (IFT57 and IFT88) and the TCR.
Zebrafish ift57, ift88, and ift172 intraflagellar transport mutants disrupt cilia but do not affect hedgehog signaling.
Perkins et al., College Station, United States. In Dev Dyn, 2009
Zebrafish IFT mutants also exhibited no dramatic changes in the craniofacial skeleton, somite formation, or motor neuron patterning.
Huntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription.
Majumder et al., Calcutta, India. In Febs J, 2008
In the present review, we present evidence that Htt-interacting protein 1 (HIP-1), an endocytic protein, together with its interacting partner HIPPI, regulates apoptosis and gene expression, both processes being implicated in HD.
BLOC1S2 interacts with the HIPPI protein and sensitizes NCH89 glioblastoma cells to apoptosis.
Roth et al., Heidelberg, Germany. In Apoptosis, 2008
Over-expression of BLOC1S2 in presence or absence of HIPPI does not induce apoptosis. However, BLOC1S2 & HIPPI sensitize NCH89 glioblastoma cells to pro-apoptotic actions of staurosporine & death ligand TRAIL.
Apoptin: therapeutic potential of an early sensor of carcinogenic transformation.
Noteborn et al., Leiden, Netherlands. In Annu Rev Pharmacol Toxicol, 2007
Apoptin targets include DEDAF, Nur77, Nmi, Hippi, and the potential drug target APC1.
The viral death effector Apoptin reveals tumor-specific processes.
Noteborn et al., Leiden, Netherlands. In Apoptosis, 2004
Finally, Apoptin interacts with various partners of the human proteome including DEDAF, Nmi and Hippi, which may help to regulate either Apoptin's activation or execution processes.
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nicholson et al., Québec, Canada. In Nat Cell Biol, 2002
Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathway.
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