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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Homeodomain interacting protein kinase 2

HIPK2, homeodomain-interacting protein kinase 2
This gene encodes a conserved serine/threonine kinase that is a member of the homeodomain-interacting protein kinase family. The encoded protein interacts with homeodomain transcription factors and many other transcription factors such as p53, and can function as both a corepressor and a coactivator depending on the transcription factor and its subcellular localization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011] (from NCBI)
Top mentioned proteins: p53, CAN, V1a, Ubiquitin, PML
Papers using HIPK2 antibodies
Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival
Huang Eric J. et al., In The Journal of Cell Biology, 2002
... EGFP-HIPK2 was detected with anti-GFP (BD Biosciences).
Papers on HIPK2
Dopaminergic Neurons and Brain Reward Pathways: From Neurogenesis to Circuit Assembly.
Huang et al., San Francisco, United States. In Am J Pathol, Jan 2016
We also discuss how mechanisms involving transforming growth factor-β and transcriptional cofactor homeodomain interacting protein kinase 2 regulate the survival and maturation of DA neurons in early postnatal life.
Genome-wide gene expression profiling of homeodomain-interacting protein kinase 2 deficient medullary thymic epithelial cells.
Kyewski et al., Heidelberg, Germany. In Genom Data, Dec 2015
Here we describe the experimental details and controls of the gene array analysis on the impact of the homeodomain-interacting protein kinase 2 (Hipk2) on promiscuous gene expression in medullary thymic epithelial cells based on the analysis of newly generated TEC-specific Hipk2 conditional knockout mice.
Apoptosis induced by a HIPK2 full-length-specific siRNA is due to off-target effects rather than prevalence of HIPK2-Δe8 isoform.
Soddu et al., Roma, Italy. In Oncotarget, Dec 2015
HIPK2 is an evolutionary conserved kinase that binds and phosphorylates several proteins directly or indirectly related to apoptosis.
Complex regulation of CREB-binding protein by homeodomain-interacting protein kinase 2.
Cardinaux et al., Lausanne, Switzerland. In Cell Signal, Nov 2015
In this study, we provide evidence of the involvement of homeodomain-interacting protein kinase 2 (HIPK2) in the regulation of CBP activity.
HIF-1α Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice.
Sopori et al., Albuquerque, United States. In Plos One, 2014
This response was associated with increased alveolar volumes, higher levels of proapoptotic factors (FOXO3a, HIPK2, p53, BIM, BIK, and BAX) and the antiangiogenic factor (GAX), and lower levels of antiapoptotic factors (Akt-PI3K, NF-κB, HIF-1α, and Bcl-2) in the lung.
HIPK2 is a new drug target for anti-fibrosis therapy in kidney disease.
He et al., New York City, United States. In Front Physiol, 2014
Here, we will discuss homeodomain-interacting-protein kinase 2 (HIPK2), a novel regulator of fibrosis that acts upstream of major fibrosis signaling pathways.
Genetic ablation of homeodomain-interacting protein kinase 2 selectively induces apoptosis of cerebellar Purkinje cells during adulthood and generates an ataxic-like phenotype.
Pierantoni et al., Napoli, Italy. In Cell Death Dis, 2014
Homeodomain-interacting protein kinase 2 (HIPK2) is a multitalented coregulator of an increasing number of transcription factors and cofactors involved in cell death and proliferation in several organs and systems.
Role of HIPK2 in kidney fibrosis.
He et al., Shanghai, China. In Kidney Int Suppl (2011), 2014
UNASSIGNED: Homeodomain interacting protein kinase 2 (HIPK2) functions as either a co-repressor or a co-activator of transcriptional regulators.
Posttranslational modifications regulate HIPK2, a driver of proliferative diseases.
Schmitz et al., Gießen, Germany. In J Mol Med (berl), 2013
The serine/threonine kinase homeodomain-interacting protein kinase (HIPK2) is a tumor suppressor and functions as an evolutionary conserved regulator of signaling and gene expression.
HIPK2: A tumour suppressor that controls DNA damage-induced cell fate and cytokinesis.
Bitomsky et al., Heidelberg, Germany. In Bioessays, 2013
Activation of the tumour suppressor HIPK2 specifies the DNA damage response (DDR) and tips the cell fate balance towards an apoptotic response.
HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody.
Soddu et al., Roma, Italy. In Mol Cell, 2012
Data indicate a critical kinase HIPK2 function in cytokinesis and in the prevention of tetraploidization.
A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.
Schmitz et al., Gießen, Germany. In Mol Cell, 2012
identify ROS-induced acetylation of the proapoptotic kinase HIPK2 as a molecular mechanism that controls the threshold discerning sensitivity from resistance toward ROS-mediated cell death
Correlation between homeodomain-interacting protein kinase 2 and apoptosis in cervical cancer.
Lu et al., Shanghai, China. In Mol Med Report, 2012
HIPK2 expression is higher in cervical cancer tissues and has a positive correlation with cervical cancer. HIPK2 may be important in the development of cervical cancer.
A systems approach identifies HIPK2 as a key regulator of kidney fibrosis.
He et al., New York City, United States. In Nat Med, 2012
This study identified homeo-domain interacting protein kinase 2 (HIPK2) as a key regulator of kidney fibrosis.
HIPK2 downregulates vimentin and inhibits breast cancer cell invasion.
D'Orazi et al., Roma, Italy. In Cancer Biol Ther, 2012
Data show that vimentin is a novel target for HIPK2 repressor function and that HIPK2-mediated vimentin downregulation can contribute to inhibition of breast cancer cells invasion.
Axin determines cell fate by controlling the p53 activation threshold after DNA damage.
Lin et al., Xiamen, China. In Nat Cell Biol, 2009
Here we show that cellular fate commitment depends on Axin forming distinct complexes with Pirh2, Tip60, HIPK2 and p53.
An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response.
Schmitz et al., Gießen, Germany. In Nat Cell Biol, 2009
As HIPK2 has an important role as a negative regulator of gene expression, its elimination from promoter-associated repressor complexes allows the induction of a substantial fraction of hypoxia-induced genes.
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
Hofmann et al., Heidelberg, Germany. In Nat Cell Biol, 2008
Results describe the control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR.
Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP.
Goodman et al., Portland, United States. In Cell, 2003
Hipk2 promotes apoptosis by downregulating Ctbp.
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