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Homeodomain interacting protein kinase 1

HIPK1, homeodomain-interacting protein kinase 1
The protein encoded by this gene belongs to the Ser/Thr family of protein kinases and HIPK subfamily. It phosphorylates homeodomain transcription factors and may also function as a co-repressor for homeodomain transcription factors. Alternative splicing results in four transcript variants encoding four distinct isoforms. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HIPK2, Fist, JNK, p53, AP-1
Papers on HIPK1
Homeodomain-interacting protein kinase 2 regulates DNA damage response through interacting with heterochromatin protein 1γ.
Rokutan et al., Tokushima, Japan. In Oncogene, Jun 2015
Homeodomain-interacting protein kinase 2 (HIPK2) is a potential tumor suppressor that has a crucial role in the DNA damage response (DDR) by regulating cell-cycle checkpoint activation and apoptosis.
miR-222 is necessary for exercise-induced cardiac growth and protects against pathological cardiac remodeling.
Rosenzweig et al., Boston, United States. In Cell Metab, May 2015
Downstream miR-222 targets modulating cardiomyocyte phenotypes were identified, including HIPK1 and HMBOX1.
Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).
Becker et al., Aachen, Germany. In Cell Commun Signal, 2014
The HIPK family includes HIPK1, HIPK2 and HIPK3, which share a similar domain structure, and the more distantly related HIPK4.
Ethnic specificity of lupus-associated loci identified in a genome-wide association study in Korean women.
Bae et al., Seoul, South Korea. In Ann Rheum Dis, 2014
Of these, 16 candidates (PEX5L, TRAJ50, MYO18B, SOS1, ARHGAP26, SMURF1, CADPS, HAND1, FAM78B, DIAPH3, TBL1XR1, CSMD1, ZBTB20, C3orf21, HIPK1 and AP001042.1)
Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development.
Strehl et al., Vienna, Austria. In Mol Cancer Res, 2014
To gain mechanistic insight into the role of PAX5 fusion proteins in leukemogenesis, the biochemical and functional properties of uncharacterized fusions: PAX5-DACH1, PAX5-DACH2, PAX5-ETV6, PAX5-HIPK1, and PAX5-POM121 were ascertained.
Integration of stress signals by homeodomain interacting protein kinases.
Hornung et al., In Biol Chem, 2014
The family of homeodomain interacting protein kinases (HIPKs) consists of four related kinases, HIPK1 to HIPK4.
Cancer/testis antigen PAGE4, a regulator of c-Jun transactivation, is phosphorylated by homeodomain-interacting protein kinase 1, a component of the stress-response pathway.
Weninger et al., Baltimore, United States. In Biochemistry, 2014
Here, we have identified homeodomain-interacting protein kinase 1 (HIPK1), also a component of the stress-response pathway, as a kinase that phosphorylates PAGE4 at T51.
Synthesis and properties of a selective inhibitor of homeodomain-interacting protein kinase 2 (HIPK2).
Pinna et al., Padova, Italy. In Plos One, 2013
Homeodomain-interacting protein kinase 2 (HIPK2) is a Ser/Thr kinase controlling cell proliferation and survival, whose investigation has been hampered by the lack of specific inhibitors able to dissect its cellular functions.
Quantification of pancreatic cancer proteome and phosphorylome: indicates molecular events likely contributing to cancer and activity of drug targets.
Pike et al., Cobham, United Kingdom. In Plos One, 2013
Mucin-1), but the majority were new candidate markers such as HIPK1 & MLCK.
MiR-19b/20a/92a regulates the self-renewal and proliferation of gastric cancer stem cells.
Fan et al., Xi'an, China. In J Cell Sci, 2013
miR-17-92 targeted the E2F1 and HIPK1 proteins, which suppressed Wnt-β-catenin signaling.
HIPK1 drives p53 activation to limit colorectal cancer cell growth.
Lartigue et al., Bordeaux, France. In Cell Cycle, 2013
HIPK1 (homeodomain interacting protein kinase 1) is a serine/threonine kinase that belongs to the CMGC superfamily.
Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.
Huang et al., San Francisco, United States. In Plos Biol, 2012
Here we show that homeodomain interacting protein kinases, HIPK1 and HIPK2, are transcriptional corepressors that regulate TGF-β-dependent angiogenesis during embryonic development.
Homeodomain-interacting protein kinase 1 (HIPK1) expression in breast cancer tissues.
Park et al., Seoul, South Korea. In Jpn J Clin Oncol, 2012
OBJECTIVE: This study investigated the incidence and clinical significance of homeodomain-interacting protein kinase 1 expression in breast cancer patients.
Mdm2 associates with Ras effector NORE1 to induce the degradation of oncoprotein HIPK1.
Choi et al., Suwŏn, South Korea. In Embo Rep, 2012
These findings indicate that the control of HIPK1 stability by Mdm2-NORE1 has a major effect on cell behaviour, and epigenetic inactivation of NORE1 enables adenocarcinoma formation in vivo through HIPK1 stabilization.
Homeodomain-interacting protein kinase (HIPK)-1 is required for splenic B cell homeostasis and optimal T-independent type 2 humoral response.
Rottapel et al., Toronto, Canada. In Plos One, 2011
Despite the expanded marginal zone B cell population in the HIPK1(-/-) mice, the T-independent type 2 humoral response was impaired.
HIPK1 interacts with c-Myb and modulates its activity through phosphorylation.
Gabrielsen et al., Oslo, Norway. In Biochem Biophys Res Commun, 2009
c-Myb appears to be phosphorylated by HIPK1 in its negative regulatory domain as supported by both in vivo and in vitro data.
SENP1 mediates TNF-induced desumoylation and cytoplasmic translocation of HIPK1 to enhance ASK1-dependent apoptosis.
Min et al., Taiwan. In Cell Death Differ, 2008
SENP1 mediates TNF-induced desumoylation and translocation of HIPK1, leading to an enhanced ASK1-dependent apoptosis.
Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals.
Koseki et al., Yokohama, Japan. In Mol Cell Biol, 2006
The present study indicated the overlapping roles for Hipk1 and Hipk2 in mediating cell proliferation and apoptosis in response to morphogenetic and genotoxic signals during mouse development.
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