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Huntingtin interacting protein 1

HIP1, Huntingtin interacting protein 1
The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] (from NCBI)
Top mentioned proteins: huntingtin, CAN, HIP1R, Actin, V1a
Papers on HIP1
Epilepsy is a possible feature in Williams-Beuren syndrome patients harboring typical deletions of the 7q11.23 critical region.
Verrotti et al., Roma, Italy. In Am J Med Genet A, Jan 2016
In WBS, epilepsy should be considered both in case of typical and atypical deletions, which do not involve HIP1, YWHAG or MAGI2.
Identification of a systemic lupus erythematosus risk locus spanning ATG16L2, FCHSD2, and P2RY2 in Koreans.
Tsao et al., Oklahoma City, United States. In Arthritis Rheumatol, Jan 2016
We replicated ten previously established SLE risk loci: STAT1-STAT4, TNFSF4, TNFAIP3, IKZF1, HIP1, IRF5, BLK, WDFY4, ETS1 and IRAK1-MECP2.
Bromodomain and hedgehog pathway targets in small cell lung cancer.
Teicher et al., Frederick, United States. In Cancer Lett, Jan 2016
The Smo antagonists, erismodegib and vismodegib and the Gli antagonists, HIP1 and SEN-450 had a trend toward greater sensitivity of the MYC amplified line.
Heterogeneous and nonlinear development of human posterior parietal cortex function.
Menon et al., Stanford, United States. In Neuroimage, Jan 2016
Activation in bilateral ventral IPS subdivision IPS-hIP1, along with adjoining anterior AG subdivision, AG-PGa, and the posterior SMG subdivision, SMG-PFm, increased linearly with age, whereas the posterior AG subdivision, AG-PGp, was equally deactivated in all three groups.
HIP1 is an Early-stage Prognostic Biomarker of Lung Adenocarcinoma and Suppresses Metastasis via Akt-mediated EMT.
Lu et al., Tainan City, Taiwan. In Am J Respir Crit Care Med, Dec 2015
Huntingtin interacting protein-1 (HIP1) is known to play a role in tumorigenesis, we tested the involvement of HIP1 in NSCLC progression and metastasis.
Physical activity, smoking, and genetic predisposition to obesity in people from Pakistan: the PROMIS study.
Saleheen et al., Malmö, Sweden. In Bmc Med Genet, 2014
We observed nominal evidence of interactions of CLIP1 rs11583200 (P interaction = 0.014), CADM2 rs13078960 (P interaction = 0.037) and GALNT10 rs7715256 (P interaction = 0.048) with physical activity, and PTBP2 rs11165643 (P interaction = 0.045), HIP1 rs1167827 (P interaction = 0.015), C6orf106 rs205262 (P interaction = 0.032) and GRID1 rs7899106 (P interaction = 0.043) with smoking on BMI.
Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives.
Bezard et al., New York City, United States. In Lancet, 2014
In Huntington's disease, strategies might also be directed at mitochondrial bioenergetics and turnover, the prevention of protein dysregulation, disruption of the interaction between huntingtin and p53 or huntingtin-interacting protein 1 to reduce apoptosis, and interference with expression of mutant huntingtin at both the nucleic acid and protein levels.
[Regulation on EGFR function via its interacting proteins and its potential application].
He et al., In Sheng Li Ke Xue Jin Zhan, 2013
LRIG1 and ACK1 enhance the internalization and degration of EGFR, while NHERF and HIP1 repress it.
Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease.
Lauterbach, Macon, United States. In Prog Neuropsychopharmacol Biol Psychiatry, 2012
RESULTS: Psychotropic drugs can meaningfully affect PD risk gene mRNA transcription, including antipsychotics (upregulate dopamine receptors D2 and D3 (DRD2, DRD3); downregulate low-density lipoprotein receptor-related protein 8 (LRP8), ubiquitin carboxyl-terminal esterase L1 (UCHL1, also known as PARK5)), haloperidol (upregulates DRD3, parkin (PRKN, also known as PARK2), DRD2; downregulates brain-derived neurotrophic factor (BDNF)), risperidone (upregulates monoamine oxidase B (MAOB), DRD2), olanzapine (upregulates transmembrane protein 163 (TMEM163), BDNF, glutathione S-transferase mu 1 (GSTM1), MAOB, DRD2, solute carrier organic anion transporter family, member 3A1 (SLCO3A1)), aripiprazole (upregulates DRD2), quetiapine, paliperidone, lurasidone, carbamazepine, and many antidepressants (upregulate BDNF), lithium and bupropion (downregulate BDNF), amitriptyline (upregulates DRD3, DRD2), imipramine (upregulates BDNF, DRD3, DRD2), desipramine (upregulates BDNF, DRD3), and fluoxetine (upregulates acid beta-glucosidase (GBA), coiled-coil domain containing 62 (CCDC62), BDNF, DRD3, UCHL1, unc-13 homolog B (UNC13B), and perhaps huntingtin interacting protein 1 related (HIP1R); downregulates microtubule-associated protein tau (MAPT), methylcrotonoyl-coenzyme A carboxylase I (MCCC1), GSTM1, 28kDa calbindin 1 (CALB1)).
HIRA, a conserved histone chaperone, plays an essential role in low-dose stress response via transcriptional stimulation in fission yeast.
Ishikawa et al., Kyoto, Japan. In J Biol Chem, 2012
Studies indicate that the fission yeast possesses two HIRA proteins Slm9 and Hip1.
Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Bahn et al., Cambridge, United Kingdom. In J Proteome Res, 2012
A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration.
Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit.
Ross et al., Ann Arbor, United States. In J Invest Dermatol, 2011
Huntingtin-interacting protein 1 is a Merkel cell carcinoma marker that interacts with c-Kit
Recurrent distal 7q11.23 deletion including HIP1 and YWHAG identified in patients with intellectual disabilities, epilepsy, and neurobehavioral problems.
Stankiewicz et al., Houston, United States. In Am J Hum Genet, 2011
data characterize a neurodevelopmental and epilepsy syndrome that is likely caused by recurrent and nonrecurrent deletions, including HIP1
Accommodation of structural rearrangements in the huntingtin-interacting protein 1 coiled-coil domain.
Fletterick et al., San Francisco, United States. In Acta Crystallogr D Biol Crystallogr, 2010
hydrogen-bond network and changes in coiled-coil monomer interaction suggest that the HIP1 coiled-coil domain is uniquely suited to allow conformational flexibility.
The Sla2p/HIP1/HIP1R family: similar structure, similar function in endocytosis?
Ashery et al., Tel Aviv-Yafo, Israel. In Biochem Soc Trans, 2010
HIP1 (huntingtin interacting protein 1) has two close relatives: HIP1R (HIP1-related) and yeast Sla2p.
Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.
Ross et al., Ann Arbor, United States. In Cancer Cell, 2009
To address these challenges, we generated mice bearing conditional knockin alleles of two human oncogenes: HIP1/PDGFbetaR (H/P) and AML1-ETO (A/E).
A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range.
Chan et al., Hong Kong, Hong Kong. In Nature, 2009
The capacity and range of signalling is thought to be regulated by its interaction with the receptor PTCH1 and antagonist HIP1.
Huntington's disease: roles of huntingtin-interacting protein 1 (HIP-1) and its molecular partner HIPPI in the regulation of apoptosis and transcription.
Majumder et al., Calcutta, India. In Febs J, 2008
In the present review, we present evidence that Htt-interacting protein 1 (HIP-1), an endocytic protein, together with its interacting partner HIPPI, regulates apoptosis and gene expression, both processes being implicated in HD.
Altered receptor trafficking in Huntingtin Interacting Protein 1-transformed cells.
Ross et al., Ann Arbor, United States. In Cancer Cell, 2003
HIP1 is the first endocytic protein to be directly implicated in tumor formation
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi.
Nicholson et al., Québec, Canada. In Nat Cell Biol, 2002
Results show that pro-apoptotic Hippi-Hip-1 heterodimers can recruit procaspase-8 into a complex of Hippi, Hip-1 and procaspase-8, and launch apoptosis through components of the 'extrinsic' cell-death pathw
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