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Keratin 86

hHb6, MNX, K86
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB3, is found primarily in the hair cortex. Mutations in this gene and KRTHB1 have been observed in patients with a rare dominant hair disease, monilethrix. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: HAIR, cytokeratin, hHb1, CAN, ACID
Papers on hHb6
Pronephric tubule morphogenesis in zebrafish depends on Mnx mediated repression of irx1b within the intermediate mesoderm.
Meyer et al., Innsbruck, Austria. In Dev Biol, Nov 2015
Studies in model organisms revealed conserved mnx gene requirements in neuronal and pancreatic development while Mnx activities that could explain the caudal mesoderm specific agenesis phenotype remain elusive.
Mn(II) Binding and Subsequent Oxidation by the Multicopper Oxidase MnxG Investigated by Electron Paramagnetic Resonance Spectroscopy.
Britt et al., Portland, United States. In J Am Chem Soc, Sep 2015
The dynamics of manganese solid formation (as MnOx) by the multicopper oxidase (MCO)-containing Mnx protein complex were examined by electron paramagnetic resonance (EPR) spectroscopy.
Blocking the tropomyosin receptor kinase A (TrkA) receptor inhibits pain behaviour in two rat models of osteoarthritis.
Walsh et al., Nottingham, United Kingdom. In Ann Rheum Dis, Sep 2015
METHODS: Knee OA was induced in rats by intra-articular monosodium-iodoacetate (MIA) injection or meniscal transection (MNX) and compared with saline-injected or sham-operated controls.
Interleukin-6 and chondrocyte mineralisation act in tandem to promote experimental osteoarthritis.
Busso et al., Lausanne, Switzerland. In Ann Rheum Dis, Sep 2015
The role of calcification in vivo was studied in the meniscectomy model of murine OA (MNX), and the link between IL-6 and cartilage degradation investigated by histology.
Oxidative stress participates in quadriceps muscle dysfunction during the initiation of osteoarthritis in rats.
Jou et al., Tainan City, Taiwan. In Int J Clin Exp Pathol, 2014
Rat osteoarthritis was initiated by conducting meniscectomy (MNX).
Peripheral opioid receptor blockade increases postoperative morphine demands--a randomized, double-blind, placebo-controlled trial.
Stein et al., Berlin, Germany. In Pain, 2014
We hypothesized that the selective blockade of peripheral opioid receptors by methylnaltrexone (MNX) would increase the patients' demand for morphine to achieve satisfactory postoperative pain relief.
Augmented pain behavioural responses to intra-articular injection of nerve growth factor in two animal models of osteoarthritis.
Walsh et al., Nottingham, United Kingdom. In Ann Rheum Dis, 2014
METHODS: OA was induced in rat knees by meniscal transection (MNX) or intra-articular monosodium iodoacetate injection (MIA).
Mitochondrial-nuclear genome interactions in non-alcoholic fatty liver disease in mice.
Bailey et al., Birmingham, United States. In Biochem J, 2014
To determine the role of mitochondrial and nuclear genomes in NAFLD, MNX (mitochondrial-nuclear exchange) mice were fed an atherogenic diet.
Clostridium geopurificans strain MJ1 sp. nov., a strictly anaerobic bacterium that grows via fermentation and reduces the cyclic nitramine explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX).
Finneran et al., Kangnŭng, South Korea. In Curr Microbiol, 2014
However, MJ1(T) transformed RDX into MNX, methylenedinitramine, formaldehyde, formate, ammonium, nitrous oxide, and nitrate.
Cellular dissection of the spinal cord motor column by BAC transgenesis and gene trapping in zebrafish.
Kawakami et al., Mishima, Japan. In Front Neural Circuits, 2012
First, by using the BAC for the Mnx class homeodomain protein gene mnr2b/mnx2b, we established the mnGFF7 transgenic line expressing the Gal4FF transcriptional activator in a large part of the motor column.
Ancient origin of somatic and visceral neurons.
Brunet et al., Paris, France. In Bmc Biol, 2012
Moreover, in the cephalopod Sepia officinalis, we show that Phox2 marks the stellate ganglion (in line with the respiratory--that is, visceral--ancestral role of the mantle, its target organ), while the anterior pedal ganglion, which controls the prehensile and locomotory arms, expresses Mnx.
A novel monilethrix mutation in coil 2A of KRT86 causing autosomal dominant monilethrix with incomplete penetrance.
Sinclair et al., Melbourne, Australia. In Br J Dermatol, 2012
Results idntify a novel mutation of krt86 protein causing monilethrix located in a region other than the helix.
Mutation E402K of the hHb6 in a Chinese Han family with monilethrix.
TIAN et al., In Eur J Dermatol, 2009
Mutation E402K of the hHb6 in a Chinese Han family with monilethrix.
[Analysis of human hair basic keratin 6 gene mutation in a Chinese Han family with monilethrix].
Yang et al., Wuhan, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 2008
The results emphasized the key role of hair keratin hHB6 in the pathogenesis of monilethrix and indicated that the common mutation of hHB6 was also a cause of monilethrix in Chinese.
Keratins of the human hair follicle.
Schweizer et al., Heidelberg, Germany. In Int Rev Cytol, 2004
The KRTHB6 expression uniformly occurred in the midcortex region.
The molecular genetics of keratin disorders.
Smith, Dundee, United Kingdom. In Am J Clin Dermatol, 2002
These include ichthyosis bullosa of Siemens (K2e), epidermolytic palmoplantar keratoderma (K1, K9), pachyonychia congenita (K6a, K6b, K16, K17), white sponge nevus (K4, K13), Meesmann's corneal dystrophy (K3, K12), cryptogenic cirrhosis (K8, K18) and monilethrix (hHb6, hHb1).In general, these disorders are inherited as autosomal dominant traits and the mutations act in a dominant-negative manner.
A mutational hotspot in the 2B domain of human hair basic keratin 6 (hHb6) in monilethrix patients.
Traupe et al., Köln, Germany. In J Invest Dermatol, 1998
Recently, causative mutations in the critical helix termination motif in the 2B domain of the human hair basic keratin 6 (hHb6) have been identified.
Sulfation of minoxidil by multiple human cytosolic sulfotransferases.
Clemens et al., Omaha, United States. In Chem Biol Interact, 1998
Thermostable phenol sulfotransferase (TS PST or P-PST) was initially thought to catalyze the reaction, and the enzyme was designated minoxidil sulfotransferase (MNX-ST).
Mutations in the hair cortex keratin hHb6 cause the inherited hair disease monilethrix.
Schweizer et al., Heidelberg, Germany. In Nat Genet, 1997
All affected individuals from a four-generation British family with monilethrix, previously linked to the type-II keratin gene cluster, as well as three unrelated single monilethrix patients, exhibited a heterozygous point mutation in the gene for type-II hair cortex keratin hHb6, leading to lysine substitution of a highly conserved glutamic acid residue in the helix termination motif (Glu 410 Lys).
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