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Complexin 2

HFB1, complexin 2, CPLX2, CPX-2
Proteins encoded by the complexin/synaphin gene family are cytosolic proteins that function in synaptic vesicle exocytosis. These proteins bind syntaxin, part of the SNAP receptor. The protein product of this gene binds to the SNAP receptor complex and disrupts it, allowing transmitter release. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: complexin I, ACID, fibrillin-1, AGE, OUT
Papers on HFB1
Heterologous expression of a hydrophobin HFB1 and evaluation of its contribution to producing stable foam.
Hosseinkhani et al., Tehrān, Iran. In Protein Expr Purif, Feb 2016
We have successfully expressed HFB1 from Trichoderma reesei belonged to class II of hydrophobins in Pichia pastoris.
Expression of the synaptic exocytosis-regulating molecule complexin 2 in taste buds and its participation in peripheral taste transduction.
Misaka et al., Tokyo, Japan. In J Neurochem, Jun 2015
Among four Cplx isoforms, strong expression of Cplx2 mRNA was detected in type III taste cells.
Complexin2 modulates working memory-related neural activity in patients with schizophrenia.
Ehrlich et al., Dresden, Germany. In Eur Arch Psychiatry Clin Neurosci, Mar 2015
Previous studies found common variants in the complexin2 (CPLX2) gene to be highly associated with cognitive dysfunction in schizophrenia patients.
In vivo formation of N-acyl-fumonisin B1.
Voss et al., Münster, Germany. In Mycotoxin Res, Feb 2015
The hydrolyzed form of FB1 (HFB1) also occurs in foods and is metabolized by rats to compounds collectively known as N-acyl-HFB1 (also known as N-acyl-AP1).
Effects of orally administered fumonisin B₁ (FB₁), partially hydrolysed FB₁, hydrolysed FB₁ and N-(1-deoxy-D-fructos-1-yl) FB₁ on the sphingolipid metabolism in rats.
Berthiller et al., Vienna, Austria. In Food Chem Toxicol, Feb 2015
Alkaline processing like nixtamalisation of maize generates partially and fully hydrolysed FB1 (pHFB1 and HFB1) and thermal treatment in the presence of reducing sugars leads to formation of N-(1-deoxy-D-fructos-1-yl) fumonisin B1 (NDF).
Ca²⁺-regulated secretory granule exocytosis in pancreatic and parotid acinar cells.
Groblewski et al., Madison, United States. In Cell Calcium, 2014
Studies indicate the early phase is triggered by Ca(2+) and involves the SG proteins VAMP2 (vesicle associated membrane protein2), Ca(2+)-sensing protein synatotagmin 1 (syt1) and the accessory protein complexin 2. The molecular details for regulation of VAMP8-mediated SG exocytosis and the prolonged phase of secretion are still emerging.
Use of liquid chromatography-high-resolution mass spectrometry for isolation and characterization of hydrolyzed fumonisins and relevant analysis in maize-based products.
Pascale et al., Bari, Italy. In J Mass Spectrom, 2014
The synthesis of partially hydrolyzed fumonisins (PHFB1 and PHFB2) and hydrolyzed fumonisins (HFB1 and HFB2) by chemical hydrolysis of pure fumonisins (FB1 and FB2) is reported together with the isolation and characterization by liquid chromatography-high-resolution mass spectrometry (LC-HRMS).
Risk and protective effects of the complexin-2 gene and gene-environment interactions in schizophrenia.
Boyajyan et al., Yerevan, Armenia. In Recent Adv Dna Gene Seq, 2013
From this point of view, complexin-2, a presynaptic regulatory protein, represents here a special interest, since it has been recently shown that genetic variants of the CPLX2 gene may affect current cognitive performance in patients with SCZ.
Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors.
Wanibuchi et al., Ōsaka, Japan. In Cancer Biomark, 2012
Based on the results of QSTAR LC-MS/MS analysis, we selected complexin-2 (CPLX2) (upregulated 8.7-fold) as a potential biomarker in high grade human LNETs, and validated its expression immunohistochemically in comparison with non-small cell lung carcinomas (NSCLCs).
Regulation of complexin 1 and complexin 2 in the developing human prefrontal cortex.
Jarskog et al., Chapel Hill, United States. In Synapse, 2008
CX2 level increased between the fetal and the 6-10 years groups and then plateaued
Fumonisin intake of the German consumer.
Märtlbauer et al., München, Germany. In Mycotoxin Res, 2008
HFBs (mostly HFB1) were frequently found in processed cereals such as corn flakes, but in relatively low concentrations.
Effect ofin vitro digestion on fumonisin B1 in corn flakes.
Scott et al., Ottawa, Canada. In Mycotoxin Res, 2007
After incubation of the samples with gastrointestinal tract solutions simulating saliva plus stomach and duodenal juices, chyme was analysed for FB1, hydrolyzed FB1 (HFB1) and partially hydrolyzed fumonisin B1 (PHFB1).
Decreased expression of vesicular glutamate transporter 1 and complexin II mRNAs in schizophrenia: further evidence for a synaptic pathology affecting glutamate neurons.
Harrison et al., Oxford, United Kingdom. In Schizophr Res, 2005
In schizophrenia, complexin II was reduced in dorsolateral prefrontal cortex and superior temporal cortex. The impairment of synaptic transmission may contribute to the dysfunction of cortical neural circuits that characterises the disorder.
Expression of mutant huntingtin blocks exocytosis in PC12 cells by depletion of complexin II.
Morton et al., Cambridge, United Kingdom. In J Biol Chem, 2003
in huntingtin mutation, the decline in neurotransmitter release is a direct consequence of complexin II depletion
[The mechanism of neurotransmitter release: role of synaphin/complexin in synaptic vesicle exocytosis].
Abe, In Tanpakushitsu Kakusan Koso, 2002
role in synaptic vesicle exocytosis
Altered immunoreactivity of complexin protein in prefrontal cortex in severe mental illness.
Honer et al., Vancouver, Canada. In Mol Psychiatry, 2001
altered immunoreactivity of this protein in prefrontal cortex in severe mental illness
Carboxypeptidases from A to z: implications in embryonic development and Wnt binding.
Fricker et al., New York City, United States. In Cell Mol Life Sci, 2001
Three other members of the metallocarboxypeptidase gene family do not appear to encode active enzymes; these members have been designated CPX-1, CPX-2 and AEBP1/ACLP.
Development and application of an enzyme-linked immunosorbent assay for the analysis of hydrolyzed fumonisins.
Schneider et al., München, Germany. In Mycotoxin Res, 2001
Polyclonal antibodies against hydrolyzed fumonisin B1 (HFB1) were prepared by immunization of rabbits with a keyhole limpet hemocyanin conjugate coupled by glutaraldehyde.
[Formation of Fumonisin artefacts in thermal treated food].
Humpf et al., Würzburg, Germany. In Mycotoxin Res, 2001
In model experiments FB1, hydrolyzed fumonisin B1 (HFB1) and N-tert-butoxycarbonyl-fumonisin B1 (N-BOC-FB1) were heated with D-glucose, respectively, and samples were analyzed by liquid chromatography/electrospray ionization-tandem-spectrometry (HPLC-MS/MS).
Antibacterial activity of a human monoclonal antibody to haemophilus influenzae type B capsular polysaccharide.
Woody et al., In Lancet, 1982
Human splenic lymphocytes were fused with a new mutant human myeloma cell line (HFB-1) to produce hybridomas that secrete human monoclonal antibodies.
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