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Hairy/enhancer-of-split related with YRPW motif-like

This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Tbx20, Rbx1, AGE, HAD, galectin-1
Papers on HEYL
Ethanol Inhibits γ-Secretase Proteolytic Activity in Vascular Smooth Muscle Cells.
Redmond et al., Dublin, Ireland. In Alcohol Clin Exp Res, Nov 2015
EtOH (25 mM) treatment inhibited DLL4-stimulated CBF-1/RBP-Jk-dependent promoter activity (determined by luciferase assay) and downstream target gene HRT-3 mRNA levels.
Myofibroblastic transformation of rat hepatic stellate cells: the role of Notch signaling and epithelial-mesenchymal transition regulation.
Lu et al., Shanghai, China. In Eur Rev Med Pharmacol Sci, Nov 2015
Notch 2 and Notch 3 receptors and Hey2 and HeyL target genes expression increased significantly as quiescent HSCs transitioned into myofibroblastic HSCs.
Morphological characteristics of the optic nerve evaluated by confocal laser tomography (HRT3) and laser polarimetry (GDx-VCC) in a normal population from the city of Barcelona.
Antón et al., Barcelona, Spain. In Arch Soc Esp Oftalmol, Nov 2015
OBJECTIVE: To evaluate morphological parameters of optic disc and retinal nerve fiber layer (RNFL) examined with confocal laser tomography (HRT3) and laser polarimetry (GDx-VCC) in a normal population, and analyze correlations of these parameters with demographic variables.
Notch signaling represses GATA4-induced expression of genes involved in steroid biosynthesis.
Wilson-Rawls et al., Québec, Canada. In Reproduction, Oct 2015
We observed that Notch downstream effectors HEY1, HEY2, and HEYL are able to differentially regulate these GATA4-dependent promoters.
Identification of substrates of F-box protein involved in methylmercury toxicity in yeast cells.
Hwang et al., Sendai, Japan. In Febs Lett, Oct 2015
We previously reported that some of the substrate proteins recognized by Hrt3 or Ucc1, a component of Skp1/Cdc53/F-box protein ubiquitin ligase, may include proteins that are involved in the methylmercury toxicity and degraded by the proteasome.
Targeting Notch signaling with a Notch2/Notch3 antagonist (tarextumab) inhibits tumor growth and decreases tumor-initiating cell frequency.
Hoey et al., Redwood City, United States. In Clin Cancer Res, Jun 2015
In the tumor stroma, OMP-59R5 consistently inhibited the expression of Notch3, HeyL, and Rgs5, characteristic of affecting pericyte function in tumor vasculature.
Cup-to-Disc Ratio From Heidelberg Retina Tomograph 3 and High-Definition Optical Coherence Tomography Agrees Poorly With Clinical Assessment.
Aung et al., Singapore, Singapore. In J Glaucoma, Apr 2015
PURPOSE: To investigate the agreement of vertical cup-to-disc ratio (VCDR) measured from Heidelberg Retina Tomograph 3 (HRT-3), high-definition optical coherence tomography (HD-OCT), and clinical grading.
Precision of the retinal tomograph as a screening device.
Sharkawi et al., Lausanne, Switzerland. In Klin Monbl Augenheilkd, Apr 2015
PURPOSE: To assess the diagnostic accuracy of the Heidelberg Retinal Tomograph 3 (HRT3) as a screening device in comparison with the reference standard of Octopus standard automated perimetry results (SAP) combined with clinical findings.
Retinal Nerve Fiber and Optic Disc Morphology in Patients with Human Immunodeficiency Virus Using the Heidelberg Retina Tomography 3.
Freeman et al., San Diego, United States. In Plos One, 2014
TESTING: Confocal scanning laser ophthalmoscopy was performed with the Heidelberg Retina Tomograph (HRT3) and data were analyzed with HRT3, software (Heyex version
Association Between Alzheimer's Disease and Glaucoma: A Study Based on Heidelberg Retinal Tomography and Frequency Doubling Technology Perimetry.
Nucci et al., Roma, Italy. In Front Neurosci, 2014
AIM: To assess the frequency of glaucoma-like alterations in Alzheimer's disease (AD) patients using Heidelberg Retinal Tomograph III (HRT-3) and Frequency Doubling Technology (FDT) perimetry.
Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus.
Gessler et al., Würzburg, Germany. In Plos One, 2014
The Hey protein family, comprising Hey1, Hey2 and HeyL in mammals, conveys Notch signals in many cell types.
[The upper limit of individual normal range of intraocular pressure--a personalized criterion for IOP evaluation].
Mamikonian, In Vestn Oftalmol, 2014
Glaucoma diagnosis was made from automated perimetry (Humphrey Visual Field Analyzer) and retinal tomography (HRT3, Cirrus HD-OCT) findings.
Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers.
Yamamoto et al., Suita, Japan. In Development, 2011
These results indicate that Hesr1 and Hesr3 are essential for the generation of adult satellite cells and for the maintenance of skeletal muscle homeostasis.
Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
Bevan et al., London, United Kingdom. In J Biol Chem, 2011
Repression of androgen receptor activity by HEYL, a third member of the Hairy/Enhancer-of-split-related family of Notch effectors.
Differential effects of the HESR/HEY transcription factor family on dopamine transporter reporter gene expression via variable number of tandem repeats.
Ishiura et al., Tokyo, Japan. In J Neurosci Res, 2011
In this study, we analyzed the effects of HESR1, -2, and -3 on DAT1 expression in human neuroblastoma SH-SY5Y cells
HeyL promotes neuronal differentiation of neural progenitor cells.
Kessler et al., Chicago, United States. In J Neurosci Res, 2011
This study demonistrated that HeyL promotes neuronal differentiation of neural progenitor cells by activating proneural genes and by inhibiting the actions of other Hes and Hey family members.
Molecular regulation of muscle stem cells by 'quiescence genes'.
Fukada, Ōsaka, Japan. In Yakugaku Zasshi, 2010
In these analyses, we found that satellite cells expressed Hesr1/Hey1 and Hesr3/HeyL genes known as down stream target of Notch signaling.
New developments in Heidelberg retina tomograph for glaucoma.
Garway-Heath et al., London, United Kingdom. In Curr Opin Ophthalmol, 2008
RECENT FINDINGS: Three main areas of investigation are covered: new developments in the third major revision of the HRT operational software (HRT-3), HRT's ability to correctly classify glaucomatous optic neuropathy, and HRT's role in monitoring disease progression.
Notch signaling in gastrointestinal tract (review).
Katoh et al., Japan. In Int J Oncol, 2007
Typical Notch ligands transduce signals to the CSL-NICD-Mastermind complex for the maintenance of stem or progenitor (transit-amplifying) cells through transcriptional activation of HES1, HES5, HES7, HEY1, HEY2 and HEYL genes, and also to the NF-kappaB-NICD complex for the augmentation of NF-kappaB signaling.
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