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Potassium voltage-gated channel, subfamily H

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, KCNQ1, HAD, SCN5A, V1a
Papers using HERG antibodies
Prefrontal cognitive systems in schizophrenia: towards human genetic brain mechanisms
Brown Jon T., In PLoS ONE, 2008
... KCNH2 cDNA and subcloned into pIRES-neo and pIRES2-eGFP (Clontech laboratories, Mountain View, CA) ...
Pharmacological rescue of trafficking defective HERG channels formed by coassembly of wild-type and long QT mutant N470D subunits
Barbuti Andrea, In PLoS ONE, 2003
... hERG isoform cDNA constructshERG1b was cloned from the human heart Marathon-Ready cDNA (Clontech, Mountain View, CA) by ...
Structural basis for modulation and agonist specificity of HCN pacemaker channels.
Attali Bernard, In PLoS ONE, 2002
... domain construct a HindIII/BamHI cDNA fragment containing the coding region corresponding to hERG residues 1–135 was cloned in-frame in pEYFP-N1 (Clontech).
Papers on HERG
Novel 1-Phenyl-3-hydroxy-4-pyridinone Derivatives as Multifunctional Agents for the Therapy of Alzheimer's Disease.
Hu et al., Hangzhou, China. In Acs Chem Neurosci, Feb 2016
Further biological evaluation revealed that it did not show obvious cytotoxicity and hERG potassium channel inhibition at micromolar concentration.
hERG 1a LQT2 C-terminus truncation mutants display hERG 1b-dependent dominant negative mechanisms.
Aromolaran et al., New York City, United States. In Heart Rhythm, Feb 2016
Mutations of hERG 1a lead to type 2 long QT syndrome (LQT2), and increased risk for fatal arrhythmias.
Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.
Smith et al., Singapore, Singapore. In Curr Comput Aided Drug Des, Feb 2016
Data for the inhibition of the hERG channel using the radio ligand binding dofetilide assay was determined for a set of 300 molecules in these therapeutic areas.
Dominant Negative Consequences of a hERG 1b-Specific Mutation Associated with Intrauterine Fetal Death.
Robertson et al., Madison, United States. In Prog Biophys Mol Biol, Feb 2016
UNASSIGNED: The human ether-a-go-go related gene (hERG) encodes two subunits, hERG 1a and hERG 1b, that combine in vivo to conduct the rapid delayed rectifier potassium current (IKr).
Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records.
Roden et al., Danville, United States. In Jama, Feb 2016
Variants in SCN5A and KCNH2, disease genes for long QT and Brugada syndromes, were assessed for potential pathogenicity by 3 laboratories with ion channel expertise and by comparison with the ClinVar database.
Discovery and SAR of N-(1-((substituted piperidin-4-yl)methyl)-3-methoxypiperidin-4-yl)-2-methoxybenzamide derivatives: 5-Hydroxytryptamine receptor 4 agonist as a potent prokinetic agent.
Jung et al., Sao Tome and Principe. In Eur J Med Chem, Jan 2016
These compounds were synthesized for high 5-HT4 receptor binding affinities and low hERG affinities.
Autonomous beating rate adaptation in human stem cell-derived cardiomyocytes.
Vunjak-Novakovic et al., New York City, United States. In Nat Commun, Dec 2015
Cardiomyocytes adapt their autonomous beating rate to the frequency at which they were stimulated, an effect mediated by the emergence of a rapidly depolarizing cell population, and the expression of hERG.
Computational investigations of hERG channel blockers: New insights and current predictive models.
Taboureau et al., Paris, France. In Adv Drug Deliv Rev, Jul 2015
Identification of potential human Ether-a-go-go Related-Gene (hERG) potassium channel blockers is an essential part of the drug development and drug safety process in pharmaceutical industries or academic drug discovery centers, as they may lead to drug-induced QT prolongation, arrhythmia and Torsade de Pointes.
Getting to the heart of hERG K(+) channel gating.
Vandenberg et al., Australia. In J Physiol, Jul 2015
Potassium ion channels encoded by the human ether-a-go-go related gene (hERG) form the ion-conducting subunit of the rapid delayed rectifier potassium current (IKr ).
Selectivity filters and cysteine-rich extracellular loops in voltage-gated sodium, calcium, and NALCN channels.
Spafford et al., Waterloo, Canada. In Front Physiol, 2014
hERG, and K2P1) contribute to a changing landscape above the pore selectivity filter that can limit drug access and serve as an ion pre-filter before ions reach the pore selectivity filter below.
Inhibitors of the renal outer medullary potassium channel: a patent review.
Calderone et al., Pisa, Italy. In Expert Opin Ther Pat, 2014
However, only few selected compounds underwent an in vivo investigation of diuretic and anti-hypertensive activities, and no data on the hERG channel are given in these patents.
The structural mechanism of KCNH-channel regulation by the eag domain.
Zagotta et al., Seattle, United States. In Nature, 2013
The KCNH voltage-dependent potassium channels (ether-à-go-go, EAG; EAG-related gene, ERG; EAG-like channels, ELK) are important regulators of cellular excitability and have key roles in diseases such as cardiac long QT syndrome type 2 (LQT2), epilepsy, schizophrenia and cancer.
Long QT syndrome-associated mutations in intrauterine fetal death.
Ackerman et al., Pavia, Italy. In Jama, 2013
LQTS type 1), KCNH2 (HERG/KV11.1,
T-wave morphology after epinephrine bolus may reveal silent long QT syndrome mutation carriers.
Lauri et al., Helsinki, Finland. In J Electrocardiol, 2012
epinephrine injection helps to distinguish silent LQTS mutation HERG carriers. This concerns also the LQT3 subtype
hERG K(+) channels: structure, function, and clinical significance.
Hill et al., Sydney, Australia. In Physiol Rev, 2012
Review: report hERG potassium channel structure, function and clinical significance.
Proton block of the pore underlies the inhibition of hERG cardiac K+ channels during acidosis.
Claydon et al., Canada. In Am J Physiol Cell Physiol, 2012
Extracellular protons inhibit hERG maximal conductance by blocking the external channel pore during acidosis.
A422T mutation in HERG potassium channel retained in ER is rescurable by pharmacologic or molecular chaperones.
Zhang et al., Nanjing, China. In Biochem Biophys Res Commun, 2012
missense A422T mutation in HERG K(+) channel results in its trafficking defect, which is rescurable by pharmacologic or molecular chaperones.
Comparative effects of liensinine and neferine on the human ether-a-go-go-related gene potassium channel and pharmacological activity analysis.
Li et al., Harbin, China. In Cell Physiol Biochem, 2011
Neferine is a more potent blocker of hERG channels than liensinine at low concentration, which may be due to higher hydrophobic nature of neferine compared with liensinine.
Modelling the long QT syndrome with induced pluripotent stem cells.
Gepstein et al., Haifa, Israel. In Nature, 2011
Here we report the development of a patient/disease-specific human iPSC line from a patient with type-2 LQTS (which is due to the A614V missense mutation in the KCNH2 gene).
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