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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Hect domain and RLD 4

HERC4 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM 179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange factor for small G proteins (Hochrainer et al., 2005 [PubMed 15676274]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: Ubiquitin, iMpact, HAD, RAD18, LGP2
Papers on Herc4
Hippo Stabilises Its Adaptor Salvador by Antagonising the HECT Ubiquitin Ligase Herc4.
Tapon et al., London, United Kingdom. In Plos One, 2014
In a cell-based RNAi screen for ubiquitin regulators involved in Sav stability, we identify the HECT domain protein Herc4 (HECT and RLD domain containing E3 ligase) as a Sav E3 ligase.
Expression of HERC4 in lung cancer and its correlation with clinicopathological parameters.
Shi et al., Guangzhou, China. In Asian Pac J Cancer Prev, 2014
HERC4, one component, is a recently identified ubiqutin ligase.
[Expression of E3 ligase HERC4 in breast cancer and its clinical implications].
Ma et al., Guangzhou, China. In Nan Fang Yi Ke Da Xue Xue Bao, 2014
OBJECTIVE: To investigate the expression of HERC4 in human breast cancer tissues and its relationship with the clinicopathological features.
Global impact of Salmonella pathogenicity island 2-secreted effectors on the host phosphoproteome.
Foster et al., Vancouver, Canada. In Mol Cell Proteomics, 2013
Our unbiased approach reveals the involvement of many previously unrecognized proteins, including E3 ligases (HERC4, RanBP2, and RAD18), kinases (CDK, SIK3, and WNK1), and histones (H2B1F, H4, and H15), in late stages of Salmonella infection.
The expression and clinical significance of HERC4 in breast cancer.
Ma et al., Guangzhou, China. In Cancer Cell Int, 2012
HERC4 is a recently identified ubiqutin ligase.
Impact of asymptomatic nodavirus carrier state and intraperitoneal viral mimic injection on brain transcript expression in Atlantic cod (Gadus morhua).
Johnson et al., St. John's, Canada. In Physiol Genomics, 2010
Several transcripts identified in the reverse SSH library, including two putative ubiquitination pathway members (HERC4 and SUMO2), were found to be significantly (P < 0.05) downregulated in individuals with a high nodavirus carrier state.
[Influence of Tripterygium wilfordii on the expression of spermiogenesis related genes Herc4, Ipo11 and Mrto4 in mice].
He et al., Shanghai, China. In Yi Chuan, 2009
Genes Herc4, Ipo11, and Mrto4, which are closely associated with spermiogenesis, were expressed irregularly.
Chromosomal characterization and localization of the NAD+-dependent histone deacetylase gene sirtuin 1 in the mouse.
Voelter-Mahlknecht et al., Homburg, Germany. In Int J Mol Med, 2009
Fluorescence in situ hybridization analysis identified a single genomic locus for the murine Sirt1 gene on chromosome 10 B4 and is neighbored by the Herc4 and Dnajc12 genes.
Disruption of the ubiquitin ligase HERC4 causes defects in spermatozoon maturation and impaired fertility.
Stewart et al., Frederick, United States. In Dev Biol, 2008
The E3 ubiquitin ligase Herc4, though ubiquitously expressed in all tissues, is most highly expressed in the testis, specifically during spermiogenesis
The human HERC family of ubiquitin ligases: novel members, genomic organization, expression profiling, and evolutionary aspects.
Kroismayr et al., Vienna, Austria. In Genomics, 2005
HERC4 ancestor emerged in nematodes and that the family expanded throughout evolution. The mRNA expression pattern of the HERC4 was found to be diverse in selected tissues and cells
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