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hephaestin, CPL, Heph
The protein encoded by this gene is similar to an iron transport protein found in mouse. The mouse protein is similar to ceruloplasmin, a serum multi-copper ferroxidase, and is thought to be a membrane-bound protein responsible for transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system. In mouse, defects in this gene can lead to severe microcytic anemia. Three transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2008] (from NCBI)
Top mentioned proteins: Ceruloplasmin, Transferrin, CAN, DMT1, ACID
Papers on hephaestin
Circularly polarized luminescence spectroscopy reveals low-energy excited states and dynamic localization of vibronic transitions in CP43.
Krausz et al., Canberra, Australia. In Biochim Biophys Acta, Jan 2016
Circularly polarized luminescence (CPL) spectroscopy is an established but relatively little-used technique that monitors the chirality of an emission.
Predicting protein folding rate change upon point mutation using residue-level coevolutionary information.
Kundu et al., Calcutta, India. In Proteins, Jan 2016
Generating residue-level coevolutionary networks of globular proteins, we analyze three parameters: relative coevolution order (rCEO), network density (ND), and characteristic path length (CPL).
Quantifying the formation of chiral luminescent lanthanide assemblies in an aqueous medium through chiroptical spectroscopy and generation of luminescent hydrogels.
Gunnlaugsson et al., Dublin, Ireland. In Faraday Discuss, Jan 2016
Both circular dichroism (CD) and circular polarised luminescence (CPL) analysis show that the complexes are chiral; giving rise to characteristic CD and CPL signatures for both the Λ and the Δ complexes, which both possess characteristic luminescence dissymmetry factors (glum), describing the structure in solution.
Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier.
Moos et al., Aalborg, Denmark. In Mol Neurobiol, Jan 2016
Transferrin receptor 1, ferrireductases Steap 2 and 3, divalent metal transporter 1 (DMT1), ferroportin, soluble and glycosylphosphatidylinositol (GPI)-anchored ceruloplasmin, and hephaestin were all expressed in brain capillaries in vivo and in isolated RBECs and RBE4 cells.
Mice with hepcidin-resistant ferroportin accumulate iron in the retina.
Dunaief et al., Philadelphia, United States. In Faseb J, Nov 2015
Immunofluorescence was used to label Fpn in retinas of mice with 4 different genotypes (wild type; Fpn C326S, a hepcidin-resistant Fpn; hepcidin knockout; and ceruloplasmin/hephaestin double knockout).
[Effects of nano-lead exposure on learning and memory as well as iron homeostasis in brain of offspring rats].
Zhang et al., In Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi, Jun 2015
The expression levels of ferritin, ferroportin 1 (FPN1), hephaestin (HP), and ceruloplasmin (CP) were measured by enzyme-linked immunosorbent assay.
Rice and Bean Targets for Biofortification Combined with High Carotenoid Content Crops Regulate Transcriptional Mechanisms Increasing Iron Bioavailability.
Martino et al., Viçosa, Brazil. In Nutrients, 2014
The evaluations included: hemoglobin gain, hemoglobin regeneration efficiency (HRE), gene expression of divalente metal transporter 1 (DMT-1), duodenal citocromo B (DcytB), ferroportin, hephaestin, transferrin and ferritin and total plasma antioxidant capacity (TAC).
Congenital pulmonary lymphangiectasis.
Resch et al., Graz, Austria. In Paediatr Respir Rev, 2014
Congenital pulmonary lymphangiectasis (CPL) is a rare vascular malformation causing dilated lymph vessels and disturbed drainage of lymph fluid.
[Ceruloplasmin, hephaestin and zyklopen: the three multicopper oxidases important for human iron metabolism].
Gromadzka et al., In Postepy Hig Med Dosw (online), 2013
Three multi-copper oxidases have been included in this group: ceruloplasmin, hephaestin and zyklopen.
Multi-copper oxidases and human iron metabolism.
MacGillivray et al., Vancouver, Canada. In Nutrients, 2013
To date, three multi-copper oxidases have been detected in humans--ceruloplasmin, hephaestin and zyklopen.
Fast-forward genetics identifies plant CPL phosphatases as regulators of miRNA processing factor HYL1.
Weigel et al., Tübingen, Germany. In Cell, 2012
MicroRNAs (miRNAs) are processed from primary transcripts that contain partially self-complementary foldbacks.
Immunoreactive hephaestin and ferroxidase activity are present in the cytosolic fraction of rat enterocytes.
Collins et al., Gainesville, United States. In Biometals, 2012
Cytosolic Heph increased upon iron-deprivation but more important, decreased significantly upon copper-deprivation, mimicking the response of membrane-bound Heph.
Intestinal iron absorption.
Anderson et al., Brisbane, Australia. In J Trace Elem Med Biol, 2012
This transporter acts in partnership with the ferroxidase hephaestin that oxidizes exported ferrous iron to facilitate its binding to plasma transferrin.
Iron repletion relocalizes hephaestin to a proximal basolateral compartment in polarized MDCK and Caco2 cells.
Vulpe et al., United States. In Biochem Biophys Res Commun, 2012
These results support the hypothesis that hephaestin is involved in iron mobilization of iron from the intestine to circulation.
Ferroportin 1 and hephaestin expression in BeWo cell line with different iron treatment.
Zhuang et al., Xi'an, China. In Cell Biochem Funct, 2012
Heph is active in placenta but may not play a key role in placental iron transport.
Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium.
Dunaief et al., Philadelphia, United States. In Am J Pathol, 2012
Cp and Heph are necessary for iron export from the retina but are not essential for iron import into the retina.
Iron efflux from oligodendrocytes is differentially regulated in gray and white matter.
David et al., Montréal, Canada. In J Neurosci, 2011
results show that Heph is expressed by oligodendrocytes and plays an important role in iron efflux from these cells.
Impact of copper limitation on expression and function of multicopper oxidases (ferroxidases).
Prohaska, Duluth, United States. In Adv Nutr, 2011
These include the hepatic secreted protein ceruloplasmin representing ∼90% of plasma copper, a splice-variant of ceruloplasmin originally characterized in brain linked by glycosylphosphatidylinositol (GPI) to membranes, an intestinal enriched MCO named hephaestin, and newly described MCO in placenta called zyklopen.
Unexpected role of ceruloplasmin in intestinal iron absorption.
Fox et al., Cleveland, United States. In Cell Metab, 2005
The paralogous vertebrate ferroxidases ceruloplasmin (Cp) and hephaestin (Heph) are considered to have nonidentical functions in iron transport: plasma Cp drives iron transport from tissue stores while intestinal Heph facilitates iron absorption from the intestinal lumen.
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse.
Anderson et al., San Francisco, United States. In Nat Genet, 1999
We describe here a novel gene, Heph, encoding a transmembrane-bound ceruloplasmin homologue that is mutant in the sla mouse and highly expressed in intestine.
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