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Hepatoma-derived growth factor

Hepatoma-derived growth factor, HDGF
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. This gene was thought initially to be located on chromosome X, however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, HAD, ACID, V1a, PCNA
Papers using Hepatoma-derived growth factor antibodies
A Statistical Model for Identifying Proteins by Tandem Mass Spectrometry.
Dasgupta Partha Sarathi, In PLoS ONE, 2002
... HDGF antibody was purchased from Santa Cruz Biotechnologies (Santa Cruz, CA) and tubulin was purchased from AbCam (Cambridge, MA) ...
Papers on Hepatoma-derived growth factor
MicroRNA-497 targets hepatoma-derived growth factor and suppresses human prostate cancer cell motility.
Zhou et al., Yancheng, China. In Mol Med Report, Feb 2016
In addition, is was indicated that miRNA‑497 directly targets hepatoma‑derived growth factor (HDGF) in prostate cancer cells.
Hepatoma-derived growth factor-related protein 2 promotes DNA repair by homologous recombination.
Jäättelä et al., Copenhagen, Denmark. In Nucleic Acids Res, Jan 2016
Here we show that the structurally related PWWP domain-containing protein, hepatoma-derived growth factor-related protein 2 (HDGFRP2), serves a similar function in homologous recombination repair.
ROS-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large scale phosphoproteomics screen.
Lavin et al., Australia. In Mol Cell Proteomics, Jan 2016
We validated the phosphorylation of three of these proteins (OSR1, HDGF and ccdc82) as ATM-dependent after H2O2 exposure and another protein (S100A11) demonstrated ATM-dependence for translocation from the cytoplasm to the nucleus.
Down-regulation of HDGF Inhibits the Growth of Hepatocellular Carcinoma Cells In Vitro and In Vivo.
Nishiguchi et al., Nishinomiya, Japan. In Anticancer Res, Dec 2015
BACKGROUND: Hepatoma-derived growth factor (HDGF) is a growth factor of various malignant diseases.
Hepatoma derived growth factor (HDGF) dynamics in ovarian cancer cells.
Prakash et al., Rochester, United States. In Apoptosis, Dec 2015
The heparin binding, hepatoma-derived growth factor (HDGF) is overexpressed in ovarian cancer cell lines and may have prognostic value, but the mechanism by which this predominantly nuclear protein is secreted or functions is unknown.
Integrated analysis of differential gene expression profiles in hippocampi to identify candidate genes involved in Alzheimer's disease.
Chen et al., Wenzhou, China. In Mol Med Report, Nov 2015
PPI network analysis showed that the significant hub proteins contained β-actin (degree, 268), hepatoma-derived growth factor (degree, 218) and WD repeat‑containing protein 82 (degree, 87).
Hepatoma-derived growth factor predicts unfavorable prognosis of epithelial ovarian cancer.
Lu et al., Linyi, China. In Onco Targets Ther, 2014
AIM: To evaluate the expression and clinical significance of hepatoma-derived growth factor (HDGF) in epithelial ovarian cancer (EOC).
Prognostic role of hepatoma-derived growth factor in solid tumors of Eastern Asia: a systematic review and meta- analysis.
Cheng et al., Jinan, China. In Asian Pac J Cancer Prev, 2014
Hepatoma-derived growth factor (HDGF) is a novel jack-of-all-trades in cancer.
HDGF: a novel jack-of-all-trades in cancer.
Cheng et al., Jinan, China. In Future Oncol, 2014
HDGF is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell transformation, apoptosis, angiogenesis and metastasis.
Hepatoma-Derived Growth Factor: Its Possible Involvement in the Progression of Hepatocellular Carcinoma.
Nishiguchi et al., Nishinomiya, Japan. In Int J Mol Sci, 2014
HDGF (hepatoma-derived growth factor) is a novel growth factor that belongs to a new gene family.
The expression and clinical significance of HDGF in osteosarcoma.
Lu et al., Linyi, China. In Onco Targets Ther, 2014
AIM: To investigate the expression of hepatoma-derived growth factor (HDGF) in osteosarcoma (OS) and the correlation with clinicopathologic factors, prognosis, and tumor progression.
Embryonic Lethality Due to Arrested Cardiac Development in Psip1/Hdgfrp2 Double-Deficient Mice.
Engelman et al., Boston, United States. In Plos One, 2014
Hepatoma-derived growth factor (HDGF) related protein 2 (HRP2) and lens epithelium-derived growth factor (LEDGF)/p75 are closely related members of the HRP2 protein family.
Critical multiple angiogenic factors secreted by glioblastoma stem-like cells underline the need for combinatorial anti-angiogenic therapeutic strategies.
Chneiweiss et al., London, United Kingdom. In Proteomics Clin Appl, 2013
Recent findings of novel GSC-secreted molecules with pro-angiogenic properties (Semaphorin 3A, hepatoma-derived growth factor) open the path to the design of a concerted attack of glioblastoma vasculature that could overcome the development of resistance to single-targeted therapies while keeping away the toxicity of the treatments.
Oncoprotein metastasis: an expanded topography.
Radulescu, Münster, Germany. In Rom J Morphol Embryol, 2012
The six proteins described here, i.e. insulin, osteopontin, interleukin-6, anterior gradient-2 protein, cellular apoptosis susceptibility protein and hepatoma-derived growth factor, as well as distinct peptide fragments thereof might henceforth serve as pivotal biomarkers for OPM in clinical chemistry, molecular morphology, pathology and oncology and, as a result, guide as potential targets future structure-based interventions in cancer treatment.
The expression and prognostic significance of hepatoma-derived growth factor in oral cancer.
Tai et al., Tainan City, Taiwan. In Oral Oncol, 2012
Hepatoma-derived growth factor overexpression contributes to the oncogenic processes in oral cancer cells
Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor.
Chneiweiss et al., Paris, France. In Stem Cells, 2012
Differential proteomic analysis of human glioblastoma and neural stem cells reveals HDGF as a novel angiogenic secreted factor
Tumorigenesis and prognostic role of hepatoma-derived growth factor in human gliomas.
Liu et al., Kao-hsiung, Taiwan. In J Neurooncol, 2012
High hepatoma-derived growth factor is associated with gliomas.
p53 negatively regulates the hepatoma growth factor HDGF.
Tokino et al., Sapporo, Japan. In Cancer Res, 2011
found that HDGF was overexpressed also in primary gastric, breast, and lung cancer tissues harboring mutant p53 genes
Overexpression of hepatoma-derived growth factor in melanocytes does not lead to oncogenic transformation.
Franken et al., Bonn, Germany. In Bmc Cancer, 2010
HDGF promotes tumor progression after secondary upregulation and may represent another protein fitting into the concept of non-oncogene addiction of tumor tissue.
Expression of hepatoma-derived growth factor is a strong prognostic predictor for patients with early-stage non-small-cell lung cancer.
Mao et al., Houston, United States. In J Clin Oncol, 2004
PURPOSE: Hepatoma-derived growth factor (HDGF), which is unrelated to hepatocyte growth factor, can stimulate DNA synthesis and cell proliferation on entering the nucleus.
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