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Hematopoietic prostaglandin D synthase

hematopoietic prostaglandin D synthase, H-PGDS
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: PGD2, MAST, ACID, lipocalin, cyclooxygenase
Papers on hematopoietic prostaglandin D synthase
Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation.
Ishii, Tsukuba, Japan. In Free Radic Biol Med, Nov 2015
The activated MAPKs p38 and ERK phosphorylate Prx6, leading to NADPH oxidase-2 activation, which contributes to production of PGD2 by hematopoietic prostaglandin D synthase (H-PGDS).
Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia.
Prabhu et al., Knoxville, United States. In Cancer Prev Res (phila), Oct 2015
Inhibition of hematopoietic-prostaglandin D synthase (H-PGDS) by HQL-79 in EPA-supplemented CML mice also blocked the effect of EPA.
Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish.
Sepulcre et al., Murcia, Spain. In Dev Comp Immunol, Oct 2015
In mammals, two types of PGDS synthase have been described, the hematopoietic (H-PGDS) and the lipocalin (L-PGDS).
Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function.
Prussin et al., Bethesda, United States. In J Allergy Clin Immunol, Oct 2015
RESULTS: peTH2 cells were identified as chemoattractant receptor-homologous molecule expressed on TH2 cells-positive (CRTH2(+)), hematopoietic prostaglandin D synthase-positive CD161(hi) CD4 T cells.
Transcriptomics of colour patterning and coloration shifts in crows.
Wolf et al., Uppsala, Sweden. In Mol Ecol, Sep 2015
Meanwhile, colour-specific expression (grey vs. black) was limited to a small number of melanogenesis genes in close association with the central transcription factor MITF (most notably HPGDS, NDP and RASGRF1).
Prostaglandin profiling reveals a role for haematopoietic prostaglandin D synthase in adipose tissue macrophage polarisation in mice and humans.
Vidal-Puig et al., Cambridge, United Kingdom. In Int J Obes (lond), Jul 2015
RESULTS: Using our modelling approach, we determined that prostglandin D₂ (PGD₂) in adipose tissue was predominantly produced in macrophages by the haematopoietic isoform of prostaglandin D synthase (H-Pgds).
Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS).
Narjes et al., Mölndal, Sweden. In Bioorg Med Chem Lett, Jul 2015
Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs.
Etiology and early pathogenesis of malignant testicular germ cell tumors: towards possibilities for preinvasive diagnosis.
Looijenga et al., Rotterdam, Netherlands. In Asian J Androl, May 2015
Since 2009, several genome wide association studies (GWAS) have been published, reporting on single-nucleotide polymorphisms (SNPs) with significant associations in or near the genes KITLG, SPRY4, BAK1, DMRT1, TERT, ATF7IP, HPGDS, MAD1L1, RFWD3, TEX14, and PPM1E, likely to be related to TGCT development.
PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
Murata et al., Tokyo, Japan. In Nat Commun, 2014
Systemic gene deficiency of haematopoietic PGD synthase (H-PGDS(-/-)) exacerbates all of the manifestations accompanying severe mast cell hyperplasia in the intestine.
Genome-wide association study of meat quality traits in chicken.
Tang et al., Yangzhou, China. In Genet Mol Res, 2014
These SNPs were located nearby or in 7 candidate genes, including CBLN2, HPGDS, SETD2, and ANKRD46, among others.
The effect of reactive oxygen species on the synthesis of prostanoids from arachidonic acid.
Chlubek et al., Szczecin, Poland. In J Physiol Pharmacol, 2013
ROS increase the activity of hematopoietic-type PGD synthase (H-PGDS), and, as a result, the production of prostaglandin D₂ (PGD₂).
Meta-analysis identifies four new loci associated with testicular germ cell tumor.
Nathanson et al., Bethesda, United States. In Nat Genet, 2013
In the combined analysis, risk of TGCT was significantly associated with markers at four previously unreported loci: 4q22.2 in HPGDS (per-allele odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.12-1.26;
Hematopoetic prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase.
Jo et al., Lexington, United States. In Endocrinology, 2012
HPGDS may play a role in the regulation of inflammation and epithelial cell health within the oviduct.
Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer.
Lin et al., Torrance, United States. In Prostaglandins Other Lipid Mediat, 2012
the Val187Ile HPGDS isoenzyme common among African Americans is not associated with colorectal cancer risk
Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level.
Fujimori et al., Takatsuki, Japan. In Mol Biol Cell, 2012
COX-1 and H-PGDS were rapidly ubiquitinated and degraded through the ubiquitin-proteasome system in response to the elevation of the intracellular calcium level
[Hematopoietic prostaglandin D synthase inhibitors for the treatment of duchenne muscular dystrophy].
Urade et al., Suita, Japan. In Brain Nerve, 2011
Hematopoietic prostaglandin (PG) D synthase (H-PGDS) was found to be induced in grouped necrotic muscle fibers of DMD patients and animal models, mdx mice, and DMD dogs.
Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein.
Boizet-Bonhoure et al., Montpellier, France. In Dev Dyn, 2011
Data suggest a role for hematopoietic prostaglandin D synthase-produced prostaglandin D(2) in the initial nuclear translocation of SOX9.
Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase.
Mayerhofer et al., München, Germany. In Fertil Steril, 2011
In patients with mixed atrophy, testicular mast cell numbers and phenotypes change with respect to the ability to express COX2 and PGDS-H.
Positioning prostanoids of the D and J series in the immunopathogenic scheme.
Scott et al., United States. In Immunol Lett, 2006
Two genetically distinct PGD(2)-synthesizing enzymes have been identified to date, including hematopoietic- and lipocalin-type PGD synthases (H-PGDS and L-PGDS, respectively).
Cloning and crystal structure of hematopoietic prostaglandin D synthase.
Hayaishi et al., Ōsaka, Japan. In Cell, 1997
The enzyme is the first member of the sigma class glutathione S-transferase (GST) from vertebrates and possesses a prominent cleft as the active site, which is never seen among other members of the GST family.
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