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HEM1 Hem1p

hem1, HEMI, hematopoietic protein 1
This gene encodes a member of the HEM family of tissue-specific transmembrane proteins which are highly conserved from invertebrates through mammals. This gene is only expressed in hematopoietic cells. The encoded protein is a part of the Scar/WAVE complex which plays an important role in regulating cell shape in both metazoans and plants. Alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, May 2010] (from NCBI)
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Top mentioned proteins: ACID, HAD, CAN, Actin, OSC
Papers on hem1
Maegele et al., Herdecke, Germany. In Shock, Oct 2015
INTRODUCTION: Different transfusion ratio concepts of red blood cells (pRBCs), fresh frozen plasma (FFPs) and platelets (PLTs) have been implemented in trauma care, but the optimal ratios are still discussed.
Serum albumin promotes ATP-binding cassette transporter-dependent sterol uptake in yeast.
Pomorski et al., Frederiksberg, Denmark. In Fems Yeast Res, 2014
We found that in both fungal species, ABC transporter-dependent uptake of cholesterol under anaerobic conditions and in mutants lacking HEM1 gene is promoted in the presence of the serum protein albumin that is able to bind the sterol molecule.
Hematopoietic protein-1 regulates the actin membrane skeleton and membrane stability in murine erythrocytes.
Iritani et al., Seattle, United States. In Plos One, 2012
In this study, we utilized mice lacking Hem-1 expression due to a non-coding point mutation in the Hem1 gene to show that absence of Hem-1 results in microcytic, hypochromic anemia characterized by abnormally shaped erythrocytes with aberrant F-actin foci and decreased lifespan.
Influence of squalene on lipid particle/droplet and membrane organization in the yeast Saccharomyces cerevisiae.
Daum et al., Graz, Austria. In Biochim Biophys Acta, 2012
Chem., 285, 6127-6133) we demonstrated that squalene, an intermediate of sterol biosynthesis, accumulates in yeast strains bearing a deletion of the HEM1 gene.
The "Raman spectroscopic signature of life" is closely related to haem function in budding yeasts.
Hamaguchi et al., Tokyo, Japan. In J Biophotonics, 2011
HEM1 gene encodes δ-aminolevulinate synthase that is required for haem synthesis.
Hem-1: putting the "WAVE" into actin polymerization during an immune response.
Iritani et al., Seattle, United States. In Febs Lett, 2011
This review focuses on a newly characterized hematopoietic cell-specific actin regulatory protein called hematopoietic protein-1 [Hem-1, also known as Nck-associated protein 1-like (Nckap1l or Nap1l)].
A point mutation in the murine Hem1 gene reveals an essential role for Hematopoietic protein 1 in lymphopoiesis and innate immunity.
Iritani et al., Seattle, United States. In J Exp Med, 2008
results demonstrate that Hem1 is essential for hematopoietic cell development, function, and homeostasis by controlling a distinct pathway leading to cytoskeletal reorganization
ATM, CTLA4, MNDA, and HEM1 in high versus low CD38 expressing B-cell chronic lymphocytic leukemia.
Joshi et al., Omaha, United States. In Clin Cancer Res, 2007
Out of these genes, HEM1, CTLA4, and MNDA were selected for further studies and their differential expression was confirmed by real-time PCR.
An actin-based wave generator organizes cell motility.
Kirschner et al., San Francisco, United States. In Plos Biol, 2007
the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile neutrophil
The CCAAT binding factor can mediate interactions between CONSTANS-like proteins and DNA.
Lifschitz et al., Haifa, Israel. In Plant J, 2006
Chromatin immunoprecipitation demonstrated that TCOL is recruited to the CCAAT motifs of the yeast CYC1 and HEM1 promoters by HAP5.
Proteomic analysis of the tetraspanin web using LC-ESI-MS/MS and MALDI-FTICR-MS.
Le Naour et al., Villejuif, France. In Proteomics, 2006
Different types of membrane proteins were identified, including adhesion molecules (integrins, Lu/B-CAM, GA733 proteins), receptors and signaling molecules (BAI2, PKC, G proteins), proteases (ADAM10, TADG15), and membrane fusion proteins (syntaxins) as well as poorly characterized proteins (CDCP1, HEM-1, CTL1, and CTL2).
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.
Kirschner et al., Boston, United States. In Plos Biol, 2006
versatile Hem-1-containing complexes coordinate diverse regulatory signals at the leading edge of polarized neutrophils, including but not confined to those involving Verprolin-homologous protein-dependent actin polymerization
A genomewide screen reveals a role of mitochondria in anaerobic uptake of sterols in yeast.
Schneiter et al., Graz, Austria. In Mol Biol Cell, 2006
Thirty-three of these mutants failed to grow on lipid-supplemented media when combined with a mutation in HEM1, which mimics anaerobic conditions in the presence of oxygen.
Cloning by genetic complementation and restriction mapping of the yeast HEM1 gene coding for 5-aminolevulinate synthase.
Labbe-Bois et al., Paris, France. In Curr Genet, 1984
We have cloned the structural gene HEM1 for 5-aminolevulinate (ALA) synthase from Saccharomyces cerevisiae by transformation and complementation of a yeast hem1-5 mutant which was previously shown to lack ALA synthase activity (Urban-Grimal and Labbe Bois 1981) and had no immunodetectable ALA synthase protein when tested with yeast ALA synthase antiserum.
Regulation of transcription of the Saccharomyces cerevisiae CYC1 gene: Identification of a DNA region involved in heme control.
Ruis et al., Vienna, Austria. In Curr Genet, 1984
A Saccharomyces cerevisiae mutant (hem1 cycl-1) was transformed with plasmids bearing a chromosomal centromer (CEN3) and a 2 μm DNA replication origin.
Cloning of the δ-aminolevulinic acid synthase structural gene in yeast.
Mattoon et al., Colorado Springs, United States. In Curr Genet, 1983
HEM1, the structural gene for δ-aminolevulinic acid synthase, has been isolated on recombinant plasmids.
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