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IKAROS family zinc finger 2

This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This protein forms homo- or hetero-dimers with other Ikaros family members, and is thought to function predominantly in early hematopoietic development. Multiple transcript variants encoding different isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: Foxp3, CAN, CD4, Ikaros, HAD
Papers using Helios antibodies
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3
Baumgrass Ria et al., In Frontiers in Immunology, 2006
... c-Fos-A488 (Santa Cruz Biotechnology), phospho-c-Jun-A488 (Santa Cruz Biotechnology), NF-κBp65-A488 (Santa Cruz Biotechnology), GITR-PE (Miltenyi), or Helios-PE (Biolegend).
Disrupted circadian rhythms in VIP and PHI deficeint mice
Chen John J et al., In Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology, 2002
... The cells were then labeled with anti-Helios (22f6) (Biolegend Cat ...
Papers on Helios
Growing Antibiotic Resistance in Fatal Cases of Staphylococcal Pneumonia in the Elderly.
Rasche et al., Wuppertal, Germany. In Adv Exp Med Biol, Feb 2016
Records of all patients aged over 65 who did not survive a bout with pneumonia were gathered from the records of the Department of Pneumology of HELIOS Clinic in Wuppertal, Germany from the period of 2004-2014.
Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection.
Yankee et al., Kansas City, United States. In Immunol Res, Jan 2016
We then analyzed protein levels of Ikaros, Helios, and Aiolos, the three Ikaros family members most abundantly expressed in human thymocytes.
Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.
HELIOS investigators et al., Jacksonville, United States. In Lancet Oncol, Jan 2016
METHODS: The HELIOS trial was an international, double-blind, placebo-controlled, phase 3 study in adult patients (≥18 years of age) who had active chronic lymphocytic leukaemia or small lymphocytic lymphoma with measurable lymph node disease (>1·5 cm) by CT scan, and had relapsed or refractory disease following one or more previous lines of systemic therapy consisting of at least two cycles of a chemotherapy-containing regimen, an Eastern Cooperative Oncology Group (ECOG) performance status of 0-1, and adequate bone marrow, liver, and kidney function.
HELIOS-A laboratory based on high-order harmonic generation of extreme ultraviolet photons for time-resolved spectroscopy.
Söderström et al., Uppsala, Sweden. In Rev Sci Instrum, Dec 2015
In this paper, we present the HELIOS (High Energy Laser Induced Overtone Source) laboratory, an in-house high-order harmonic generation facility which generates extreme ultraviolet (XUV) photon pulses in the range of 15-70 eV with monochromatized XUV pulse lengths below 35 fs.
Stable inhibitory activity of regulatory T cells requires the transcription factor Helios.
Cantor et al., Boston, United States. In Science, Nov 2015
We report that impaired expression of the transcription factor (TF) Helios by FoxP3(+) CD4 and Qa-1-restricted CD8 T(regs) results in defective regulatory activity and autoimmunity in mice.
Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis.
Healy et al., Southampton, United Kingdom. In Lancet, Mar 2015
The inhibitory receptor CTLA4 and the transcription factor Helios were expressed at high levels in peritumoral Tregs.
Integration of genomic data enables selective discovery of breast cancer drivers.
Pe'er et al., New York City, United States. In Cell, 2015
We developed Helios, an algorithm that integrates genomic data from primary tumors with data from functional RNAi screens to pinpoint driver genes within large recurrently amplified regions of DNA.
No Resistance to Penicillin, Cefuroxime, Cefotaxime, or Vancomycin in Pneumococcal Pneumonia.
Rasche et al., Wuppertal, Germany. In Int J Med Sci, 2014
METHODS: All of the required information from inpatients who were identified to have group B streptococcal pneumonia was sourced from the database at the Department of Internal Medicine of HELIOS Clinic Wuppertal, Witten/Herdecke University, in Germany, from 2004-2014.
Modulation of Cytokine Secretion Allows CD4 T Cells Secreting IL-10 and IL-17 to Simultaneously Participate in Maintaining Tolerance and Immunity.
Valmori et al., Saint-Herblain, France. In Plos One, 2014
We found that circulating CD4 T cells secreting IL-10 or/and IL-17 ex vivo include both conventional FOXP3- CD4 T cells and FOXP3+ Helios- Treg.
Transcriptional regulation and T cell exhaustion.
Henderson et al., Boston, United States. In Curr Opin Hiv Aids, 2014
There exists a subset of transcription factors associated with exhaustion, notably Blimp-1, basic leucine zipper transcription factor, ATF-like and Helios.
Surgical management of periprosthetic joint infection: one-stage exchange.
Gehrke et al., Hamburg, Germany. In J Knee Surg, 2014
This article describes the one-staged exchange in infected PJI of the knee joint, which has been established 40 years ago in the HELIOS ENDO-Klinik Hamburg, Germany.
Lung microbiota promotes tolerance to allergens in neonates via PD-L1.
Marsland et al., Lausanne, Switzerland. In Nat Med, 2014
Immediately following birth, neonatal mice were prone to develop exaggerated airway eosinophilia, release type 2 helper T cell cytokines and exhibit airway hyper-responsiveness following exposure to house dust mite allergens, even though their lungs harbored high numbers of natural CD4(+)Foxp3(+)CD25(+)Helios(+) regulatory T (Treg) cells.
tTregs, pTregs, and iTregs: similarities and differences.
Thornton et al., Bethesda, United States. In Immunol Rev, 2014
The expression of the transcription factor Helios has proven to be a useful marker for the identification of stable tTregs in both mouse and human.
Automated antinuclear immunofluorescence antibody screening: a comparative study of six computer-aided diagnostic systems.
Study Group on Autoimmune Diseases of the Italian Society of Laboratory Medicine et al., Italy. In Autoimmun Rev, 2014
Therefore, the study with the following automatic instrumentation was conducted on 92 ANA-positive sera and on 34 ANA-negative sera: Aklides, EUROPattern, G-Sight (I-Sight-IFA), Helios, Image Navigator, and Nova View.
FoxP3, Helios, and SATB1: roles and relationships in regulatory T cells.
Witkowski et al., Chicago, United States. In Int Immunopharmacol, 2013
Two of them, Helios and SATB1, are considered to be important in proper Treg development.
Cutting edge: in the absence of TGF-β signaling in T cells, fewer CD103+ regulatory T cells develop, but exuberant IFN-γ production renders mice more susceptible to helminth infection.
Maizels et al., Edinburgh, United Kingdom. In J Immunol, 2012
Presence of Helios-positive regulatory T (Treg) cells may maintain susceptibility to helminth infection on the C57BL/6 mouse background.
Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses.
Ugolini et al., Marseille, France. In Science, 2012
down-regulation of NK cell activity by NKp46 was associated with the silencing of the Helios transcription factor in NK cells
Phenotypic and functional properties of Helios+ regulatory T cells.
Drake et al., Baltimore, United States. In Plos One, 2011
In tumor-bearing mice, Helios(+) regulatory T cells were relatively over-represented in the tumor-mass.
Helios is associated with CD4 T cells differentiating to T helper 2 and follicular helper T cells in vivo independently of Foxp3 expression.
Mohr et al., Birmingham, United Kingdom. In Plos One, 2010
Data show that Helios is selectively upregulated in CD4 T cells during Th2 and TFh responses to alum-protein vaccines in vivo, independently of Foxp3 expression.
Helios expression is a marker of T cell activation and proliferation.
Hancock et al., Philadelphia, United States. In Plos One, 2010
Data found that Helios-negative T cells are enriched for naive T cell phenotypes and vice versa. Moreover, Helios can be induced during T cell activation and proliferation, but regresses in the same cells under resting conditions.
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