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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Helicase, POLQ-like

HEL308 is a single-stranded DNA-dependent ATPase and DNA helicase (Marini and Wood, 2002 [PubMed 11751861]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: POLYMERASE, ATPase, THETA, CAN, RPA
Papers on HEL308
Structure of the Helicase Domain of DNA Polymerase Theta Reveals a Possible Role in the Microhomology-Mediated End-Joining Pathway.
Gileadi et al., Oxford, United Kingdom. In Structure, Jan 2016
Comparisons with related helicases from the Hel308 family identify several unique features.
Subangstrom single-molecule measurements of motor proteins using a nanopore.
Gundlach et al., Seattle, United States. In Nat Biotechnol, Oct 2015
We use ion current modulation through the protein nanopore MspA to observe translocation of helicase Hel308 on DNA with up to ∼40 pm sensitivity.
Brr2 plays a role in spliceosomal activation in addition to U4/U6 unwinding.
Zhao et al., Aurora, United States. In Nucleic Acids Res, May 2015
Brr2 is a large protein (∼250 kD) that consists of an N-terminal domain (∼500 residues) with unknown function and two Hel308-like modules that are responsible for RNA unwinding.
Direct Detection of Unnatural DNA Nucleotides dNaM and d5SICS using the MspA Nanopore.
Gundlach et al., Seattle, United States. In Plos One, 2014
We find that both phi29 DNA polymerase and Hel308 helicase are capable of controlling the motion of DNA containing dNaM and d5SICS through the pore and that single reads are sufficient to detect the presence and location of dNaM and d5SICS within single molecules.
Genetic variants in DNA repair pathway genes and risk of esophageal squamous cell carcinoma and gastric adenocarcinoma in a Chinese population.
Taylor et al., Bethesda, United States. In Carcinogenesis, 2013
We observed several other genes significantly associated with either ESCC (SMUG1, TDG, TP53, GTF2H3, FEN1, POLQ, HEL308, RAD54B, MPG, FANCE and BRCA1) or GC risk (MRE11A, RAD54L and POLE) (P < 0.05).
Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population.
Shen et al., Nanjing, China. In Hum Genet, 2013
We found significant association with risk of ESCC for four SNPs, including rs1494961 in HEL308 at 4q21 [odds ratio (OR) = 1.15, 95 % confidence interval (CI) = 1.05-1.26],
Genetic manipulation in Sulfolobus islandicus and functional analysis of DNA repair genes.
She et al., Wuhan, China. In Biochem Soc Trans, 2013
However, among seven homologous recombination proteins, including RadA, Hel308/Hjm, Rad50, Mre11, HerA, NurA and Hjc, only the Hjc nuclease is dispensable for cell viability.
Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22.
Ficner et al., Göttingen, Germany. In Biol Chem, 2012
The similarity of these helicase-associated CTDs to the winged-helix and ratchet domains of the DNA helicase Hel308 suggests an analogous function in dsRNA binding and unwinding.
Gene-environment interactions of novel variants associated with head and neck cancer.
Kelsey et al., Providence, United States. In Head Neck, 2012
RESULTS: A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack-years and HNSCC.
Human HEL308 localizes to damaged replication forks and unwinds lagging strand structures.
McHugh et al., Oxford, United Kingdom. In J Biol Chem, 2011
one role for HEL308 at sites of blocked replication might be to open up the parental strands to facilitate the loading of subsequent factors required for replication restart.
Physical interaction between archaeal DNA repair helicase Hel308 and Replication Protein A (RPA).
Bolt et al., Nottingham, United Kingdom. In Dna Repair (amst), 2011
Hel308 is a super-family 2 helicase in archaea with homologues in higher eukaryotes (HelQ and PolQ) that contribute to repair of DNA strand crosslinks (ICLs).
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.
Brennan et al., Lyon, France. In Plos Genet, 2011
Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10⁻⁸) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p =2 × 10⁻⁸) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene.
Winged helix domains with unknown function in Hel308 and related helicases.
Bolt et al., Nottingham, United Kingdom. In Biochem Soc Trans, 2011
Hel308 is a superfamily 2 helicase/translocase that is conserved throughout archaea and in some eukaryotes for repair of genotoxic lesions such as ICLs (interstrand DNA cross-links).
In silico investigation of conformational motions in superfamily 2 helicase proteins.
Mikhailov et al., Berlin, Germany. In Plos One, 2010
Here, we consider three helicases from the major superfamily 2--Hef, Hel308 and XPD--and study their conformational dynamics by using coarse-grained relaxational elastic network models.
Molecular biology of Hel308 helicase in archaea.
Bolt et al., Nottingham, United Kingdom. In Biochem Soc Trans, 2009
Hel308 is an SF2 (superfamily 2) helicase with clear homologues in metazoans and archaea, but not in fungi or bacteria.
POLN, a nuclear PolA family DNA polymerase homologous to the DNA cross-link sensitivity protein Mus308.
Wood et al., Pittsburgh, United States. In J Biol Chem, 2003
identification of homolog to POLN
A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308.
Wood et al., Pittsburgh, United States. In J Biol Chem, 2002
A human DNA helicase homologous to the DNA cross-link sensitivity protein Mus308
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