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Headcase homolog

This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E-selectin, CD45, L-selectin, P-selectin, CAN
Papers using HECA antibodies
Varicella-Zoster Virus Transfer to Skin by T Cells and Modulation of Viral Replication by Epidermal Cell Interferon-α
Arvin Ann M. et al., In The Journal of Experimental Medicine, 1991
... anti-CD19 (clone SJ25-C1, mIgG1), anti-CD45RA (clone MEM56, mIgG2b) (Caltag Inc.), and anti–cutaneous lymphocyte antigen (CLA) (HECA-452, rat IgM; BD Biosciences).
Papers on HECA
ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes.
Neelamegham et al., London, United Kingdom. In Blood, Feb 2015
Reduction in ST3Gal-4 activity lowered cell-surface HECA-452 epitope expression by 75% to 95%.
CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions.
Burdick et al., Athens, United States. In Am J Physiol Cell Physiol, 2015
Surprisingly, CD44 was not recognized by the HECA-452 MAb, which detects sialofucosylated epitopes traditionally expressed by selectin ligands, suggesting that BT-20 cells express a novel glycoform of CD44v as an E-selectin ligand.
The Human Homolog of Drosophila Headcase Acts as a Tumor Suppressor through Its Blocking Effect on the Cell Cycle in Hepatocellular Carcinoma.
Zhang et al., Xi'an, China. In Plos One, 2014
The abnormal expression of the human homolog of Drosophila headcase (HECA homo) has been found in pancreatic, colorectal, and oral squamous cell carcinoma.
L-selectin ligands expression in human fallopian tube epithelia of tubal pregnancies.
Zhang et al., Shanghai, China. In Biol Reprod, 2014
Expression of L-selectin ligands was evaluated by immunohistochemistry with antibodies against HECA-452 and MECA-79 and by real-time PCR.
Identification of hypo- and hypermethylated genes related to atherosclerosis by a genome-wide analysis of DNA methylation.
Sawabe et al., Tsu, Japan. In Int J Mol Med, 2014
Three of the hypomethylated genes [Drosophila headcase (HECA), early B-cell factor 1 (EBF1) and nucleotide-binding oligomerization domain containing 2 (NOD2)] and three of the hypermethylated genes [human mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), zinc finger E-box binding homeobox 1 (ZEB1) and FYN] were previously been implicated in atherosclerosis.
Competition between core-2 GlcNAc-transferase and ST6GalNAc-transferase regulates the synthesis of the leukocyte selectin ligand on human P-selectin glycoprotein ligand-1.
Neelamegham et al., Buffalo, United States. In J Biol Chem, 2013
In particular, ST6GalNAc2 overexpression abrogated cell surface HECA-452/CLA expression, reduced the number of rolling leukocytes on P- and L-selectin-bearing substrates by ~85%, and increased median rolling velocity of remaining cells by 80-150%.
Integrative analyses of gene expression and DNA methylation profiles in breast cancer cell line models of tamoxifen-resistance indicate a potential role of cells with stem-like properties.
Ditzel et al., In Breast Cancer Res, 2012
A panel of genes, including NRIP1, HECA and FIS1, exhibited lower gene expression in resistant vs. parental cells and concurrent increased promoter CGI methylation in resistant vs. parental cell lines.
HECA-452 is a non-function blocking antibody for isolated sialyl Lewis x adhesion to endothelial expressed E-selectin under flow conditions.
Goetz et al., Athens, United States. In J Immunol Methods, 2012
HECA-452 is a monoclonal antibody (mAb) that recognizes sLe(x) and is routinely used by investigators from diverse fields who seek to unravel the mechanisms of leukocyte adhesion.
The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells.
Reichert et al., Regensburg, Germany. In Exp Cell Res, 2012
HECA expression is markedly decreased in oral squamous cell carcinoma (OSCC) compared to controls and is associated with decreased sensitivity to cisplatin in OSCC cell lines
Mac-2 binding protein is a novel E-selectin ligand expressed by breast cancer cells.
Burdick et al., Athens, United States. In Plos One, 2011
Consistent with their E-selectin ligand activity, ZR-75-1 cells expressed flow cytometrically detectable epitopes of HECA-452 mAb, which recognizes high efficiency E-selectin ligands typified by sialofucosylated moieties.
Prominent expression of sialyl Lewis X-capped core 2-branched O-glycans on high endothelial venule-like vessels in gastric MALT lymphoma.
Nakayama et al., Matsumoto, Japan. In J Pathol, 2011
We have investigated sialyl Lewis X (sLeX)-related glycoepitopes and found that MECA-79(-) /HECA-452(+) /NCC-ST-439(+) HEV-like vessels preferentially mark gastric MALT lymphoma compared to chronic H. pylori gastritis.
Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins.
Neelamegham et al., Buffalo, United States. In Blood, 2010
Consistent with this hypothesis, 50muM per-acetylated 4F-GalNAc added to the growth media of promyelocytic HL-60 cells reduced the expression of the cutaneous lymphocyte associated-antigen (HECA-452 epitope) by 82% within 2 cell doubling cycles.
The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells.
Reichert et al., Regensburg, Germany. In Carcinogenesis, 2009
Human HECA slows down cell division of oral squamous cell carcinoma cells and may therefore act as a tumor suppressor in head and neck cancer.
Detection of site-specific glycosylation in proteins using flow cytometry.
Neelamegham et al., Buffalo, United States. In Cytometry A, 2009
The carbohydrate epitope associated with the released peptide was detected using HECA-452 and CSLEX-1, monoclonal antibodies that recognize the sialyl Lewis-X epitope.
A homologue of the Drosophila headcase protein is a novel tumor marker for early-stage colorectal cancer.
Huang et al., Taipei, Taiwan. In Oncol Rep, 2006
Data show that HECA may be an early-stage classifier of colorectal cancer that can discriminate between late- and early-stage disease.
Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells.
Kupper et al., Boston, United States. In Nature, 1997
CLA is defined by both its reactivity with a unique monoclonal antibody, HECA-452, and its activity as a ligand for E-selectin, but the structure of the protein component of CLA has not previously been defined.
Adhesion molecules on endothelial cells in the central nervous system: an emerging area in the neuroimmunology of multiple sclerosis.
Cross et al., New York City, United States. In Clin Immunol Immunopathol, 1990
On the basis of evidence from the literature and pilot data on the localization of the putative vascular addressin for humans, HECA-452, in central nervous system (CNS) tissue, it is suggested that molecular recognition on CNS EC might play a pathogenetic role during immune-mediated demyelination in multiple sclerosis (MS).
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