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Transcription factor 12

HEB, ME1, Malic enzyme
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: E12, ACID, CAN, TFE, HAD
Papers using HEB antibodies
From Mallory to Mallory-Denk bodies: What, how and why?
Omary M. Bishr et al., In The Journal of Cell Biology, 2006
... (6C5), CYP3A1, FAH, PDIA4 (ERp72), lamin B1, PRDX6, and Siah1 (Abcam); GSTM1, CBR3, CA3, and ME1 (Santa Cruz Biotechnology, Inc.); panactin and β-tubulin ...
Papers on HEB
Antigenic evolution of H9N2 chicken influenza viruses isolated in China during 2009-2013 and selection of a candidate vaccine strain with broad cross-reactivity.
Pu et al., Beijing, China. In Vet Microbiol, Feb 2016
A vaccine candidate, Ck/HeB/YT/10, was selected and provided significant protection against viruses from different antigenic groups in terms of reduction in virus shedding, suggesting broad cross-reactivity.
Artificial selection on introduced Asian haplotypes shaped the genetic architecture in European commercial pigs.
Groenen et al., Beuningen, Netherlands. In Proc Biol Sci, Jan 2016
However, regions with an excess or absence of Asian haplotypes (AS) contained genes that were previously identified as phenotypically important such as FASN, ME1, and KIT.
Temperature and magnetic field-assisted switching of magnetization and observation of exchange bias in YbCrO3 nanocrystals.
Poddar et al., New Delhi, India. In Inorg Chem, Nov 2015
The YCO also showed Hext and T-dependent HEB, which changed its sign with T. The observed T-dependent sign reversal in the EB was closely associated with the sign reversal of MZFC.
Metabolic engineering of Mortierella alpina for arachidonic acid production with glycerol as carbon source.
Chen et al., Wuxi, China. In Microb Cell Fact, 2014
Overexpression of malic enzyme (ME1) but not glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase or isocitrate dehydrogenase significantly increased fatty acid content when glycerol was used as carbon source.
The establishment of B versus T cell identity.
Murre et al., San Diego, United States. In Trends Immunol, 2014
In B cell progenitors, E-proteins E2A and HEB (HeLa E-box binding protein) are crucial for the induction of a B lineage-specific program of gene expression and for orchestrating the assembly of the immunoglobulin loci.
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence.
Yang et al., Philadelphia, United States. In Nature, 2013
Downregulation of ME1 and ME2 also modulates the outcome of p53 activation, leading to strong induction of senescence, but not apoptosis, whereas enforced expression of either malic enzyme suppresses senescence.
Antibacterial Peptides, Probiotic Properties and Biopreservative Efficacy of Native Bacillus Species Isolated from Different Food Sources.
Halami et al., Mysore, India. In Probiotics Antimicrob Proteins, 2012
The ABP present in the cell-free supernatant of B. subtilis Ec1 and B. licheniformis Me1 exhibited the highest titre of activity (3,400 AU/ml) and wide range of pH (4-10) and temperature (40-100 °C) stability.
Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.
Look et al., Boston, United States. In Cancer Cell, 2012
Here we identify the core transcriptional regulatory circuit controlled by TAL1 and its regulatory partners HEB, E2A, LMO1/2, GATA3, and RUNX1.
Loss of E protein transcription factors E2A and HEB delays memory-precursor formation during the CD8+ T-cell immune response.
Goldrath et al., San Diego, United States. In Eur J Immunol, 2012
Deficiency in the E proteins, E2A and HEB, led to increased frequency of terminally differentiated effector KLRG1(hi) CD8(+) T cells in mice during infection, and decreased generation of longer-lived memory-precursor cells during the immune response.
Basement membrane assembly of the integrin α8β1 ligand nephronectin requires Fraser syndrome-associated proteins.
Sekiguchi et al., Suita, Japan. In J Cell Biol, 2012
the loss of QBRICK significantly diminished The expression of nephronectin, an integrin alpha8beta1 ligand necessary for renal development.
E protein transcription factors are required for the development of CD4(+) lineage T cells.
Zhuang et al., Durham, United States. In Immunity, 2012
Deletion of HEB and E2A in DP thymocytes specifically blocked the development of CD4(+) lineage T cells. Furthermore, deletion of the E protein inhibitors Id2 and Id3 allowed CD4(+) T cell development but blocked CD8(+) lineage development.
TCF12 protein functions as transcriptional repressor of E-cadherin, and its overexpression is correlated with metastasis of colorectal cancer.
Huang et al., Taiwan. In J Biol Chem, 2012
TCF12 functioned as a transcriptional repressor of E-cadherin and its overexpression was significantly correlated with the occurrence of CRC metastasis.
HEB in the spotlight: Transcriptional regulation of T-cell specification, commitment, and developmental plasticity.
Anderson et al., Toronto, Canada. In Clin Dev Immunol, 2011
These processes require Notch signaling and the activity of GATA3, TCF1, Bcl11b, and the E-proteins HEB and E2A.
The transcription factors E2A and HEB act in concert to induce the expression of FOXO1 in the common lymphoid progenitor.
Murre et al., San Diego, United States. In Proc Natl Acad Sci U S A, 2011
the earliest event in B-cell specification involves the induction of FOXO1 expression and requires the combined activities of E2A and HEB
E proteins and the regulation of early lymphocyte development.
Kee et al., Chicago, United States. In Immunol Rev, 2010
Although the other E proteins, HEB and E2-2, are expressed during lymphopoiesis and can compensate for some of E2A's activity, E2A proteins have non-redundant functions during early T-cell development and at multiple checkpoints throughout B lymphopoiesis.
An essential role for the transcription factor HEB in thymocyte survival, Tcra rearrangement and the development of natural killer T cells.
Goldrath et al., San Diego, United States. In Nat Immunol, 2010
HEB is a specific and essential factor in T-cell development and in the generation of the iNKT cell lineage.
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.
Drake et al., Los Angeles, United States. In Nat Genet, 2009
Perturbation of eight out of the nine genes, with Gas7, Me1 and Gpx3 being newly confirmed, resulted in significant changes in obesity-related traits.
Regulation of V(D)J recombination by E-protein transcription factors.
Zhuang et al., Durham, United States. In Adv Exp Med Biol, 2008
Extensive study of the E-proteins E2A and HEB duringlymphocyte development has revealed various functions for these bHLH transcription factors in regulating V(D)J recombination in both B- and T-cells.
At the crossroads: diverse roles of early thymocyte transcriptional regulators.
Anderson, Toronto, Canada. In Immunol Rev, 2006
The regulatory modules that control expression of T-lineage genes frequently include binding sites for a core set of regulators that set the T-cell-specific background for signal-dependent control, including GATA-3, Notch/CSL, c-myb, TCF-1, Ikaros, HEB/E2A, Ets, and Runx factors.
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