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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.


The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2011] (from NCBI)
Top mentioned proteins: HAD, AGE, Insulin, fibrillin-1, CAN
Papers using HDL antibodies
Vitamin D receptor ligands: the impact of crystal structures
Sanz Yolanda, In PLoS ONE, 2011
... Serum content of total cholesterol, triglyceride, HDL, LDL, AST and ALT were measured by enzymatic assays (Wako Chemicals; Osaka, Japan) ...
Novel HDL-directed pharmacotherapeutic strategies
Kocher Olivier, In PLoS ONE, 2010
... Human HDL was purchased from Biomedical Technologies, Inc ...
Suppression of fatty acid synthase, differentiation and lipid accumulation in adipocytes by curcumin.
Schneider-Stock Regine, In PLoS ONE, 2010
... Kits for glucose, cholesterol, free fatty acids (FFA), and HDL assessment were from Abcam (Cambridge, MA) ...
Association of CD36 gene variants rs1761667 (G>A) and rs1527483 (C>T) with Type 2 diabetes in north Indian population
Banerjee Monisha et al., In The Indian Journal of Medical Research, 2009
... glucose (mg/dl), serum insulin (mg/dl) and lipid profile (total serum cholesterol, TC; High density lipoprotein-cholesterol, HDL-C and serum triglycerides, TG) were done using commercially available Ecoline kits (Merck, India) by double beam ...
Determination of apparent and true dietary fatty acid digestibilities and metabolisable energy using ileal digesta and excreta from broiler chickens
Ghosh Tapan Kumar et al., In Veterinary Medicine International, 1995
... Concentrations of glucose, total protein, albumin, cholesterol, HDL-cholesterol, and triacylglycerol in serum were determined in a semiautomatic blood biochemistry analyzer (Microlab 200, Merck, manufactured by Vital Scientific, ...
Papers on HDL
Increased HDL Size and Enhanced Apo A-I Catabolic Rates Are Associated With Doxorubicin-Induced Proteinuria in New Zealand White Rabbits.
Pérez-Méndez et al., Mexico. In Lipids, Feb 2016
UNASSIGNED: The catabolism and structure of high-density lipoproteins (HDL) may be the determining factor of their atheroprotective properties.
Interaction of lipoprotein lipase polymorphisms with body mass index and birth weight to modulate lipid profiles in children and adolescents: the CASPIAN-III Study.
Kelishadi et al., Eşfahān, Iran. In Sao Paulo Med J, Feb 2016
RESULTS: The AG/GG genotype in D9N polymorphism was associated with higher LDL-C (low-density lipoprotein cholesterol) and lower HDL-C (high-density lipoprotein cholesterol) concentration.
The problem of atrial fibrillation in patients with chronic kidney disease.
Rysz et al., Łódź, Poland. In Curr Vasc Pharmacol, Feb 2016
Factors contributing to the occurrence of AF in patients undergoing dialysis include: age, presence of coronary heart disease, echocardiographic abnormalities (low ejection fraction, atrial enlargement, valvular calcification, left ventricular hypertrophy), heart failure, chronic obstructive pulmonary disease, hypertension, stroke, malnutrition (low levels of albumin, total cholesterol and high-density lipoprotein (HDL), secondary hyperparathyroidism, low predialysis systolic blood pressure, duration of renal replacement therapy as well as the method of renal replacement therapy (more frequent in haemodialysis patients).
Gut microbiota-derived lipopolysaccharide uptake and trafficking to adipose tissue: implications for inflammation and obesity.
Loft et al., Copenhagen, Denmark. In Obes Rev, Jan 2016
These CMs are transported via lymph to the circulation, where LPS is transferred to other lipoproteins by translocases, preferentially to HDL.
Cholesterol crystal induced arterial inflammation and destabilization of atherosclerotic plaque.
Abela et al., East Lansing, United States. In Eur Heart J, Jan 2016
Membrane-bound cholesterol carriers transport FRC to high-density lipoprotein (HDL).
Discovery of 2-azetidinone and 1H-pyrrole-2,5-dione derivatives containing sulfonamide group at the side chain as potential cholesterol absorption inhibitors.
Zhang et al., Nanjing, China. In Bioorg Med Chem Lett, Jan 2016
Finally, 9e considerably reduced total cholesterol, LDL-C, FFA and triglyceride in the serum and increased the rate of HDL-C to total cholesterol, suggesting it could regulate the lipid metabolism and act as a potent CAI.
What does the future hold for cholesteryl ester transfer protein inhibition?
Kastelein et al., Naarden, Netherlands. In Curr Opin Lipidol, Dec 2015
The association between HDL cholesterol levels and cardiovascular risk, albeit strong and consistent, is unlikely to be of causative nature, at least according to genetic epidemiology.
Diet in children with phenylketonuria and risk of cardiovascular disease: A narrative overview.
Giovannini et al., Milano, Italy. In Nutr Metab Cardiovasc Dis, Dec 2015
No difference was observed in overweight prevalence and in high-density lipoprotein cholesterol (HDL-C) levels.
MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels.
Fernández-Hernando et al., New Haven, United States. In Nat Med, Nov 2015
Moreover, we found that miR-148a regulates hepatic expression of ATP-binding cassette, subfamily A, member 1 (ABCA1) and circulating high-density lipoprotein cholesterol (HDL-C) levels in vivo.
Cholesterol ester transfer protein inhibition by TA-8995 in patients with mild dyslipidaemia (TULIP): a randomised, double-blind, placebo-controlled phase 2 trial.
Barter et al., Amsterdam, Netherlands. In Lancet, Sep 2015
METHODS: In this randomised, double-blind, placebo-controlled, parallel-group phase 2 trial, we recruited patients (aged 18-75 years) from 17 sites (hospitals and independent clinical research organisations) in the Netherlands and Denmark with fasting LDL cholesterol levels between 2·5 mmol/L and 4·5 mmol/L, HDL cholesterol levels between 0·8 and 1·8 mmol/L and triglyceride levels below 4·5 mmol/L after washout of lipid-lowering treatments.
HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.
Hla et al., New York City, United States. In Nature, Aug 2015
Although the majority of plasma S1P is bound to apolipoprotein M (ApoM) in the high-density lipoprotein (HDL) particle, the immunological functions of the ApoM-S1P complex are unknown.
Genetic Variation Determines PPARγ Function and Anti-diabetic Drug Response In Vivo.
Lazar et al., Philadelphia, United States. In Cell, Aug 2015
One PPARγ motif-altering SNP is associated with HDL levels and other metabolic syndrome parameters.
Randomized Multicenter Placebo-Controlled Trial of Omega-3 Fatty Acids for the Control of Aromatase Inhibitor-Induced Musculoskeletal Pain: SWOG S0927.
Moinpour et al., Seattle, United States. In J Clin Oncol, Jul 2015
No between-group differences were seen for HDL, LDL, or C-reactive protein.
Biphasic Regulation of Lipid Metabolism: A Meta-Analysis of Icodextrin in Peritoneal Dialysis.
Zhang et al., Daliang, China. In Biomed Res Int, 2014
In the subgroup of patients with diabetes (Martikainen et al., 2005, Sniderman et al., 2014, and Takatori et al., 2011), differential of high-density lipoprotein cholesterol (HDL-C) in the ICO group was less.
Cholesterol Transporters ABCA1 and ABCG1 Gene Expression in Peripheral Blood Mononuclear Cells in Patients with Metabolic Syndrome.
Goodarzi et al., Hamadān, Iran. In Cholesterol, 2014
Comparison of other parameters such as HDL-C, FBS, BMI, waist circumference, and systolic and diastolic blood pressure between metabolic syndrome patients and healthy individuals showed significant differences (P < 0.05).
Polymorphisms of POR, SULT2A1 and HSD11B1 in children with premature adrenarche.
Voutilainen et al., Kuopio, Finland. In Metabolism, 2012
Common polymorphisms at POR, SULT2A1 or HSD11B1 were not associated with PA in a Finnish Caucasian population.
Expression of 11β-hydroxysteroid dehydrogenase enzymes in human osteosarcoma: potential role in pathogenesis and as targets for treatments.
Cooper et al., Birmingham, United Kingdom. In Endocr Relat Cancer, 2012
Expression of 11beta-hydroxysteroid dehydrogenase enzymes in human osteosarcoma.
Association study of CYP17 and HSD11B1 in polycystic ovary syndrome utilizing comprehensive gene coverage.
Goodarzi et al., Los Angeles, United States. In Mol Hum Reprod, 2012
genetic association studies in population of women in Alabama: Data suggest that genetic variations in HSD11B1 and CYP17A1 are not major risk factors for polycystic ovary syndrome; 8 SNP in HSD11B1 and 4 SNP in CYP17A1 were investigated.
Salicylate downregulates 11β-HSD1 expression in adipose tissue in obese mice and in humans, mediating insulin sensitization.
Walker et al., Edinburgh, United Kingdom. In Diabetes, 2012
Reduced intra-adipose glucocorticoid regeneration by 11beta-HSD1 is a novel mechanism that contributes to the metabolic efficacy of salicylates.
Association between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population.
Causevic et al., Sarajevo, Bosnia and Herzegovina. In Biochem Med (zagreb), 2011
11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms is associated with protective effect against insulin resistance.
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