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Histone deacetylase 7

HDAC7, histone deacetylase 7, HD7
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene has sequence homology to members of the histone deacetylase family. This gene is orthologous to mouse HDAC7 gene whose protein promotes repression mediated via the transcriptional corepressor SMRT. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Histone, HDAC, histone deacetylase, CAN, CYP3A4
Papers using HDAC7 antibodies
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain
Casaccia-Bonnefil Patrizia et al., In The Journal of Cell Biology, 2002
... Santa Cruz Biotechnology, Inc.); HDAC6 (1:100 for IHC, 1:500 for WB; Santa Cruz Biotechnology, Inc.); HDAC7 (1:100 for IHC, 1:500 for WB; Santa Cruz Biotechnology, Inc.); HDAC8 (1:100 for ...
Papers on HDAC7
An Acute Methamphetamine Injection Downregulates the Expression of Several Histone Deacetylases (HDACs) in the Mouse Nucleus Accumbens: Potential Regulatory Role of HDAC2 Expression.
Cadet et al., Baltimore, United States. In Neurotox Res, Jan 2016
We found that METH decreased HDAC3, HDAC4, HDAC7, HDAC8, and HDAC11 mRNA expression but increased HDAC6 mRNA levels in the NAc of WT mice.
Expression of biomarker genes of differentiation in D3 mouse embryonic stem cells after exposure to different embryotoxicant and non-embryotoxicant model chemicals.
Sogorb et al., Elx, Spain. In Data Brief, Dec 2015
We studied a set of 16 different genes biomarkers of general cellular processes (Cdk1, Myc, Jun, Mixl, Cer and Wnt3), ectoderm formation (Nrcam, Nes, Shh and Pnpla6), mesoderm formation (Mesp1, Vegfa, Myo1e and Hdac7) and endoderm formation (Flk1 and Afp).
Expression of class II HDACs in two mouse models of temporal lobe epilepsy.
Sperk et al., Innsbruck, Austria. In J Neurochem, Dec 2015
Beyond this, striking similarities between both TLE models such as fast decreases in HDAC7 and 10 mRNAs during the acute status epilepticus were observed, notably also in the contralateral hippocampus not affected by neurodegeneration.
Isotype-Specific Inhibition of Histone Deacetylases: Identification of Optimal Targets for Radiosensitization.
Kim et al., Seoul, South Korea. In Cancer Res Treat, Dec 2015
Results: Among 11 HDAC isotypes tested, specific inhibition of 7 isotypes (HDAC1, HDAC3, HDAC4, HDAC6, HDAC7, HDAC10, and HDAC11) enhanced radiation lethality in SQ20B cells.
The potential role of the NEK6, AURKA, AURKB, and PAK1 genes in adenomatous colorectal polyps and colorectal adenocarcinoma.
Korkmaz et al., Manisa, Turkey. In Tumour Biol, Oct 2015
PAK1, NEK6, AURKA, AURKB, HDAC1, and HDAC7 were significantly more overexpressed in CRC subjects compared to the controls (p < 0.05).
Epigenetic therapy of cancer with histone deacetylase inhibitors.
Saldanha et al., Bengaluru, India. In J Cancer Res Ther, 2014
HDAC enzymes are grouped into four different classes namely Class I (HDAC1, HDAC2, HDAC3, and HDAC8), Class II (HDAC4, HDAC5, HDAC6, HDAC7, HDAC9, and HDAC10), Class III HDAC and Class IV (HDAC11).
Role of caspase-8 in thymus function.
Delfino et al., Perugia, Italy. In Cell Death Differ, 2014
The death receptors Fas, FADD, and FLIP are involved upstream of caspase-8 activation in apoptosis; whereas, Bid and HDAC7 are involved downstream of caspase-8.
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency.
Vignali et al., Memphis, United States. In Immunity, 2012
Foxp3(gfp) was unable to interact with the histone acetyltransferase Tip60, the histone deacetylase HDAC7, and the Ikaros family zinc finger 4, Eos, which led to reduced Foxp3 acetylation and enhanced K48-linked polyubiquitylation.
Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7.
Ito et al., London, United Kingdom. In Chest, 2012
HDAC7 reduction in COPD causes a defect of HIF-1alpha induction response to hypoxia with impaired VEGF gene expression. This poor cellular adaptation might play a role in the pathogenesis of COPD.
Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation.
Xu et al., Beijing, China. In Arterioscler Thromb Vasc Biol, 2011
Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear beta-catenin translocation.
Histone deacetylase 7 regulates cell survival and TCR signaling in CD4/CD8 double-positive thymocytes.
Verdin et al., San Francisco, United States. In J Immunol, 2011
Data suggest that HDAC7 nuclear export governs a self-sustaining autoexcitatory loop.
HDAC3 and HDAC7 have opposite effects on osteoclast differentiation.
Mansky et al., Minneapolis, United States. In J Biol Chem, 2011
Data demonstrate that Mitf and HDAC7 interact in RAW 264 cells and osteoclasts. The transcriptional activity of Mitf is repressed by HDAC7.
Phosphoproteomic analysis reveals an intrinsic pathway for the regulation of histone deacetylase 7 that controls the function of cytotoxic T lymphocytes.
Cantrell et al., Dundee, United Kingdom. In Nat Immunol, 2011
Data indicate that CTLs had high expression of the histone deacetylase HDAC7 but continually phosphorylated and exported this transcriptional repressor from the nucleus.
PiggyBac transposon mutagenesis: a tool for cancer gene discovery in mice.
Bradley et al., Cambridge, United Kingdom. In Science, 2010
The PiggyBac screen uncovered many cancer genes not identified in previous retroviral or Sleeping Beauty transposon screens, including Spic, which encodes a PU.1-related transcription factor, and Hdac7, a histone deacetylase gene.
Hypoxia and angiogenesis: regulation of hypoxia-inducible factors via novel binding factors.
Shibasaki et al., Tokyo, Japan. In Exp Mol Med, 2010
Here, we review our findings on the interactions of basic HIFs, HIF-1 alpha and HIF-2 alpha, with their regulatory binding proteins, histone deacetylase 7 (HDAC7) and translation initiation factor 6 (Int6), respectively.
Novel structural insights into class I and II histone deacetylases.
Ficner, Göttingen, Germany. In Curr Top Med Chem, 2008
recent developments in the crystal structure analysis of human HDAC4, HDAC7, and HDAC8 recent developments in the crystal structure analysis of human HDAC4, HDAC7, and HDAC8 [REVIEW]
Two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine plus extended-field radiotherapy is superior to radiotherapy alone in early favorable Hodgkin's lymphoma: final results of the GHSG HD7 trial.
Diehl et al., Köln, Germany. In J Clin Oncol, 2007
PURPOSE: To investigate whether combined-modality treatment (CMT) with two cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by extended-field radiotherapy (EF-RT) is superior to EF-RT alone in patients with early favorable Hodgkin's lymphoma (HL).
Outcome of patients experiencing progression or relapse after primary treatment with two cycles of chemotherapy and radiotherapy for early-stage favorable Hodgkin's lymphoma.
Josting et al., Köln, Germany. In J Clin Oncol, 2007
PATIENTS AND METHODS: Of 1,129 patients with early-stage favorable HL enrolled onto the HD7/HD10/HD13 trials of the German Hodgkin Study Group, 42 patients were identified with treatment failure, of whom eight had primary progressive disease, seven had early relapse (< or = 12 months), and 27 had late relapse (> 12 months).
HDAC7 regulates apoptosis in developing thymocytes.
Kasler et al., San Francisco, United States. In Novartis Found Symp, 2003
We have recently reported that HDAC7, a class II histone deacetylase, is highly expressed in CD4+CD8+ double positive thymocytes.
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