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Histone deacetylase 2

HDAC2, histone deacetylase 2, HD2
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010] (from NCBI)
Top mentioned proteins: Histone, HDAC, CYP3A4, CAN, V1a
Papers using HDAC2 antibodies
Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster.
Oshima Robert, In PLoS ONE, 2005
... endothelial growth factor (VEGF, Santa Cruz Biotechnology), thrombospondin -1 (TSP-1) (Lab Vision, Fremont, CA, USA), HDAC2 (Abcam, Cambridge, UK), and actin ...
Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain
Casaccia-Bonnefil Patrizia et al., In The Journal of Cell Biology, 2002
... HDAC1 (1:6,000 for IHC, 1:4,000 for WB; Affinity BioReagents, Inc.); HDAC2 (1:100 for IHC, 1:1,000 for WB; Santa Cruz Biotechnology, Inc.); HDAC3 (1:100 for ...
Papers on HDAC2
Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro.
Chen et al., Shanghai, China. In Acta Pharmacol Sin, Feb 2016
The expression levels of relevant proteins were examined using immunoblotting assays or immunohistochemistry. RESULTS: P-aIgA1 (25-250 μg/mL) dose-dependently promoted the proliferation of HMCs, and markedly increased the protein levels of type I histone deacetylase (HDAC1, HDAC2 and HDAC8) in the cells.
Chidamide and 5-flurouracil show a synergistic antitumor effect on human colon cancer xenografts in nude mice.
Chen et al., In Neoplasma, Feb 2016
UNASSIGNED: Chidamide is a novel histone deacetylase (HDAC) inhibitor that increases the acetylation of histone H3 by inhibiting the activity of HDAC1 and HDAC2.
Inhibition of class I histone deacetylases 1 and 2 promotes urothelial carcinoma cell death by various mechanisms.
Niegisch et al., In Mol Cancer Ther, Feb 2016
UNASSIGNED: Class I histone deacetylases HDAC1 and HDAC2 contribute to cell proliferation and are commonly upregulated in urothelial carcinoma (UC).
p21 and CK2 interaction-mediated HDAC2 phosphorylation modulates KLF4 acetylation to regulate bladder cancer cell proliferation.
Zhang et al., Beijing, China. In Tumour Biol, Feb 2016
Mechanistically, p21 and CK2 interaction, but not CK2 alone, enhanced HDAC2 phosphorylation and restricted KLF4 deacetylation and subsequent tumor promotion.
dbEM: A database of epigenetic modifiers curated from cancerous and normal genomes.
Raghava et al., Chandīgarh, India. In Sci Rep, Dec 2015
In our analysis, we found that epigenetic proteins DNMT3A, HDAC2, KDM6A, and TET2 are highly mutated in variety of cancers.
Genome-Wide Association Study of Event-Free Survival in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy.
Cerhan et al., Bordeaux, France. In J Clin Oncol, Dec 2015
RESULTS: In a meta-analysis of the four studies, the top loci for EFS were marked by rs7712513 at 5q23.2 (near SNX2 and SNCAIP; HR, 1.39; 95% CI, 1.23 to 1.57; P = 2.08 × 10(-7)), and rs7765004 at 6q21 (near MARCKS and HDAC2; HR, 1.38; 95% CI, 1.22 to 1.57; P = 7.09 × 10(-7)), although they did not reach conventional genome-wide significance (P = 5 × 10(-8)).
Molecular control of CD4(+) T cell lineage plasticity and integrity.
Ellmeier, Vienna, Austria. In Int Immunopharmacol, Oct 2015
Moreover, the analysis of mice with a conditional deletion of the transcription factor ThPOK or the histone deacetylases HDAC1 and HDAC2 indicated that CD8 lineage genes are actively repressed in CD4(+) T cells in order to maintain the lineage integrity of helper T cells.
Tet2 is required to resolve inflammation by recruiting Hdac2 to specifically repress IL-6.
Cao et al., Beijing, China. In Nature, Oct 2015
For the repression mechanism, independent of DNA methylation and hydroxymethylation, Tet2 recruited Hdac2 and repressed transcription of Il6 via histone deacetylation.
Non-sirtuin histone deacetylases in the control of cardiac aging.
McKinsey et al., Aurora, United States. In J Mol Cell Cardiol, Jun 2015
HDAC2, HDAC3 and HDAC6).
Microsatellite instability: an update.
Imai et al., Kawasaki, Japan. In Arch Toxicol, Jun 2015
Gene targets of frameshift mutations caused by MSI are involved in various cellular functions, including DNA repair (MSH3 and MSH6), cell signaling (TGFBR2 and ACVR2A), apoptosis (BAX), epigenetic regulation (HDAC2 and ARID1A), and miRNA processing (TARBP2 and XPO5), and a subset of MSI+ CRCs reportedly shows the mutated miRNA machinery phenotype.
Histone deacetylases in memory and cognition.
Tsai et al., Cambridge, United States. In Sci Signal, 2015
In particular, we focus on HDAC2, which plays a central role in coupling lysine acetylation to synaptic plasticity and mediates many of the effects of HDAC inhibition in cognition and disease.
Histone deacetylases 1 and 2 are required for brain development.
Zalewska et al., Warsaw, Poland. In Int J Dev Biol, 2014
In line with this, gene disruption studies have shown that the class I deacetylases, HDAC1 and HDAC2 play an essential role in nervous system development.
Chromatin repressive complexes in stem cells, development, and cancer.
Helin et al., Copenhagen, Denmark. In Cell Stem Cell, 2014
Here, we review the roles of the polycomb repressive complexes, PRC1 and PRC2, and the HDAC1- and HDAC2-containing complexes, NuRD, Sin3, and CoREST, in stem cells, development, and cancer, as well as the ongoing efforts to develop therapies targeting these complexes in human cancer.
CD4(+) T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2.
Ellmeier et al., Vienna, Austria. In Nat Immunol, 2014
Here we show histone deacetylases 1 and 2 (HDAC1 and HDAC2) as crucial regulators of this process.
Epigenetic priming of memory updating during reconsolidation to attenuate remote fear memories.
Tsai et al., Cambridge, United States. In Cell, 2014
We find that, whereas recent memory recall induces a limited period of hippocampal neuroplasticity mediated, in part, by S-nitrosylation of HDAC2 and histone acetylation, such plasticity is absent for remote memories.
Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.
Skawran et al., Hannover, Germany. In Gastroenterology, 2012
In hepatocellular carcinoma cells, up-regulation of HDAC1-3 reduces expression of miR-449, activating hepatocyte growth factor and altering tumor growth.
HDAC2 overexpression confers oncogenic potential to human lung cancer cells by deregulating expression of apoptosis and cell cycle proteins.
Nam et al., Seoul, South Korea. In J Cell Biochem, 2012
findings suggest the aberrant regulation of HDAC2 and its epigenetic regulation of gene transcription in apoptosis and cell cycle components play an important role in the development of lung cancer
Differential modulation of the oligodendrocyte transcriptome by sonic hedgehog and bone morphogenetic protein 4 via opposing effects on histone acetylation.
Casaccia et al., New York City, United States. In J Neurosci, 2012
Silencing of histone deacetylase 2 or histone deacetylase 1 in oligodendrocyte progenitor cells, prevented sonic hedgehog-induced oligodendrocyte differentiation and favored the expression of astrocytic genes.
Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication.
Tang et al., Ponce, Puerto Rico. In J Biol Chem, 2012
Data show that leucine zipper domain, not the SUMOylation of K-bZIP, is required for K-bZIP to interact with HDAC1/2 and with some KSHV lytic gene promoters and that these interactions are important for human herpesvirus-8 to replicate.
An epigenetic blockade of cognitive functions in the neurodegenerating brain.
Tsai et al., Cambridge, United States. In Nature, 2012
cognitive capacities in the neurodegenerating brain are constrained by an epigenetic blockade of gene transcription; this blockade is mediated by histone deacetylase 2, which is increased by Alzheimer's-disease-related neurotoxic insults
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