Paneth cell α-defensin 6 (HD-6) is an antimicrobial peptide.
Stuttgart, Germany. In Mucosal Immunol, May 2015
Human α-defensin 6 (HD-6) is produced exclusively by small intestinal Paneth cells but, in contrast to other antimicrobial peptides (AMPs) for HD-6, no direct antibacterial killing activity has been detected so far.
Defensins in innate immunity.
Xi'an, China. In Curr Opin Hematol, 2014
RECENT FINDINGS: A novel mode of antibacterial action is described for human enteric alpha-defensin 6, which forms structured nanonets to entrap bacterial pathogens and protect against bacterial invasion of the intestinal epithelium.
Role of defensins and cathelicidin LL37 in auto-immune and auto-inflammatory diseases.
Roma, Italy. In Curr Pharm Biotechnol, 2012
In particular, we refer to the human alpha-defensins called human neutrophil peptides (HNP1 through 4), which are produced by neutrophils, HD5 and HD6, mainly expressed in Paneth cells of intestine, the human beta-defensins HBD1, HBD2 and HBD3, synthesized by epithelial cells and LL37, which is located in granulocytes, but is also produced by epithelial cells of the skin, lungs, and gut.
α-Defensins in human innate immunity.
Los Angeles, United States. In Immunol Rev, 2012
The properties of HD6, an enigmatic Paneth cell α-defensin, are contrasted with those of the four myeloid α-defensins (HNP1-4) and of HD5, the other α-defensin of human Paneth cells.