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Non-SMC condensin II complex, subunit D3

hCAP-D3, HCP6, hHCP-6, CAPD3
Condensin complexes I and II play essential roles in mitotic chromosome assembly and segregation. Both condensins contain 2 invariant structural maintenance of chromosome (SMC) subunits, SMC2 (MIM 605576) and SMC4 (MIM 605575), but they contain different sets of non-SMC subunits. NCAPD3 is 1 of 3 non-SMC subunits that define condensin II (Ono et al., 2003 [PubMed 14532007]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: MUC4, CAN, BAD, C-Nap1, SET
Papers on hCAP-D3
AZGP-1 immunohistochemical marker in prostate cancer: potential predictive marker of biochemical recurrence in post radical prostatectomy specimens.
Cho et al., Seoul, South Korea. In Appl Immunohistochem Mol Morphol, 2014
To select prognostic/predictive markers of postoperative biochemical recurrence (BCR) that could be easily performed in daily pathology practice, the expression of 6 immunohistochemical markers including zinc-α-2-glycoprotein (AZGP-1), hCAP-D3, mucin 1, vimentin, E-cadherin, and ERG was assessed in a tissue microarray of 400 radical prostatectomy specimens.
The Arabidopsis CAP-D proteins are required for correct chromatin organisation, growth and fertility.
Schubert et al., Germany. In Chromosoma, 2013
In Arabidopsis thaliana, we identified two candidate genes (Cap-D2 and Cap-D3) which may express conserved proteins presumably associated with condensin.
Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I.
Heidmann et al., Bayreuth, Germany. In Plos Genet, 2013
Mass-spectrometric analyses of proteins associated with the condensin II-specific subunit Cap-H2 not only fail to identify Cap-G but also the other known condensin II-specific homolog Cap-D3.
The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
Hirota et al., Tokyo, Japan. In Genes Dev, 2011
The initial phase of chromosome condensation requires Cdk1-mediated phosphorylation of the CAP-D3 subunit of condensin II.
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
Rosenfeld et al., San Diego, United States. In Nature, 2010
Accordingly, the HEAT repeat clusters in two non-structural maintenance of chromosomes (SMC) condensin II subunits, N-CAPD3 and N-CAPG2 (also known as NCAPD3 and NCAPG2, respectively), are capable of recognizing H4K20me1, and ChIP-Seq analysis demonstrates a significant overlap of condensin II and H4K20me1 sites in mitotic HeLa cells.
The chromosomal association of condensin II is regulated by a noncatalytic function of PP2A.
Kimura et al., Tsukuba, Japan. In Nat Struct Mol Biol, 2009
We show here that protein phosphatase 2A (PP2A), which interacts with condensin II but not condensin I, plays an essential role in targeting condensin II to chromosomes.
Condensin II resolves chromosomal associations to enable anaphase I segregation in Drosophila male meiosis.
Bosco et al., Tucson, United States. In Plos Genet, 2008
Here, we demonstrate that two predicted condensin II subunits, Cap-H2 and Cap-D3, are required to promote territory formation.
RBF1 promotes chromatin condensation through a conserved interaction with the Condensin II protein dCAP-D3.
Dyson et al., United States. In Genes Dev, 2008
The re-expression of pRB into a pRB-deficient human tumor cell line promotes chromatin association of hCAP-D3 in a manner that depends on the LXCXE-binding cleft of pRB.
hCAP-D3 expression marks a prostate cancer subtype with favorable clinical behavior and androgen signaling signature.
Pollack et al., Stanford, United States. In Am J Surg Pathol, 2008
hCAP-D3 is a new biomarker for subtype-1 prostate tumors that improves prognostication.
Evidence for less irritation to the peritoneal membrane in rats dialyzed with solutions low in glucose degradation products.
Breborowicz et al., Poznań, Poland. In Perit Dial Int, 2004
The following PDF were tested: CAPD3 (single-chamber bag, low pH, high GDP), CAPD3 pH 7.4 (single-chamber bag, neutral pH, high GDP), CAPD3-Balance (double-chamber bag, neutral pH, low GDP).
Identification of a subunit of a novel Kleisin-beta/SMC complex as a potential substrate of protein phosphatase 2A.
Ogris et al., Vienna, Austria. In Curr Biol, 2004
We isolated a human homolog of C. elegans HCP6, a protein distantly related to the condensin subunit hCAP-D2, and we named this homolog hHCP-6.
Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.
Hirano et al., United States. In Cell, 2003
The CAP-D3 subunit of the condensin II complex implicated in chromosome assembly and segeregation
Morphologic changes in the liver of dialyzed rats--preliminary observations.
Oreopoulos et al., Poznań, Poland. In Adv Perit Dial, 2002
Rats were exposed intraperitoneally to 0.9% NaCl, phosphate-buffered saline (PBS), or commercial dialysis solutions containing 3.86% glucose (Dianeal 3.86%: Baxter Healthcare SA, Castlebar, Ireland; CAPD3 and CAPD3-Balance: Fresenius Medical Care, Bad Homburg, Germany) twice daily for 4-6 weeks.
Peritoneal dialysate fluid composition determines heat shock protein expression patterns in human mesothelial cells.
Aufricht et al., Vienna, Austria. In Kidney Int, 2001
METHODS: Human mesothelial cells (Met5A and primary human mesothelial cells) were exposed to acidic lactate and glucose-monomer based PDF (CAPD2 and CAPD3), to control culture media, or to a neutral lactate and glucose-monomer-based PDF with reduced levels of glucose degradation products (BALANCE).
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