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Defensin, beta 104A

hBD-4, DEFB104, DEFB4, beta-defensin-4, BD4, mBD4
Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Defensins are short, processed peptide molecules that are classified by structure into three groups: alpha-defensins, beta-defensins and theta-defensins. All beta-defensin genes are densely clustered in four to five syntenic chromosomal regions. Chromosome 8p23 contains at least two copies of the duplicated beta-defensin cluster. This duplication results in two identical copies of defensin, beta 104, DEFB104A and DEFB104B, in head-to-head orientation. This gene, DEFB104A, represents the more centromeric copy. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: Defensin, hBD-2, CAN, POLYMERASE, HAD
Papers using hBD-4 antibodies
Bovine viral diarrhoea virus antigenic diversity: impact on disease and vaccination programmes
Thacker H. Leon et al., In Veterinary Medicine International, 2002
... region were retested by RT-PCR using primers BD1/BD4 [19].The amplified PCR products were purified using a commercial purification kit (QIAGEN (QIAGEN, Calif, USA)) according ...
Papers on hBD-4
Association of β-defensin gene copy number variations with ankylosing spondylitis in Chinese population: A case-control study.
Pan et al., Hefei, China. In Mod Rheumatol, Jan 2016
The copy numbers of DEFB4 gene (2 fragments) were measured by AccuCopy™ methods.
Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response.
Watanabe et al., Tokyo, Japan. In J Dermatol, Jan 2016
Clinically, i.p. injected LCN2 exacerbated erythema and scaling in IMQ-treated murine skin compared with phosphate-buffered saline injection alone, and it augmented interleukin (IL)-17A, IL-17F, IL-22, IL-23p19, IL-12p40, CCL20, tumor necrosis factor-α, chemokine (C-X-C motif) ligand (CXCL)1, CXCL2, DEFB4, DEFB14, LCN2 and S100A7 mRNA levels of IMQ-treated murine skin while it did not increase the mRNA levels of interferon-γ, IL-12p35 or CXCL10.
Association of Higher Defensin β-4 Genomic Copy Numbers with Behçet's Disease in Iraqi Patients.
Norgauer et al., Baghdad, Iraq. In Sultan Qaboos Univ Med J, Nov 2015
The aim of the present study was to investigate the possible association of BD in its various clinical forms with defensin β-4 (DEFB4) genomic copy numbers.
Increased expression of IL-17 pathway genes in non-lesional skin of moderate-to-severe psoriasis vulgaris.
Krueger et al., New York City, United States. In Br J Dermatol, Aug 2015
The increased expression of IL-17-signature genes, including DEFB4 and S100A7, was associated with an increased number of CD3+, CD8+, and DC-LAMP+ cells that we observed in NL skin vs. normal controls.
Characterization of Desulfovibrio biadhensis sp. nov., isolated from a thermal spring.
Fardeau et al., Tunis, Tunisia. In Int J Syst Evol Microbiol, Apr 2015
A novel anaerobic, mesophilic, slightly halophilic sulfate-reducing bacterium, designated strain Khaled BD4(T), was isolated from waters of a Tunisian thermal spring.
Mándi et al., In Ideggyogy Sz, Apr 2015
It is in our interest to investigate the relevance of the single nucleotide polymorphisms (SNPs) of the DEFB1 gene and the copy number polymorphism of the DEFB4 genes in MS.
[Effect of shikonin on proliferation of keratinocytes induced by interleukin-17 and expression of chemokines].
Li et al., In Zhongguo Zhong Yao Za Zhi, Mar 2015
The expressions of intracellular chemokines CXCL1, CXCL2, CCL20 and 6-defensin 4 (DEFB4) were detected by Real-time PCR.
Effect of Hangeshashinto on calprotectin expression in human oral epithelial cells.
Kido et al., Tokushima, Japan. In Odontology, Mar 2015
HST (6 μg/ml) increased the expression of S100A8/S100A9 mRNAs and calprotectin protein, and also up-regulated β-defensin 2 (DEFB4) and S100A7 expression.
Black Tea Extract and Its Theaflavin Derivatives Inhibit the Growth of Periodontopathogens and Modulate Interleukin-8 and β-Defensin Secretion in Oral Epithelial Cells.
Grenier et al., São Paulo, Brazil. In Plos One, 2014
The ability of the black tea extract and its theaflavin derivatives to induce the secretion of the antimicrobial peptides hBD-1, hBD-2 and hBD-4 by oral epithelial cells was then evaluated.
Expression and new exon mutations of the human Beta defensins and their association on colon cancer development.
Alanazi et al., Riyadh, Saudi Arabia. In Plos One, 2014
This study was designed to analyze the expression and genetic variations in hBDs (hBD-1, hBD-2, hBD-3 and hBD-4) and their putative association with colon cancer.
Genetics of psoriatic arthritis.
Rahman et al., St. John's, Canada. In Best Pract Res Clin Rheumatol, 2014
Searching for different types of genetic variants such as small CNVs and/or insertions/deletions has also led to the identification of several genes with a function relative to PsV in particular including DEFB4, LCE3C_LCE3B, and IL-22 gene (exon 1).
The pathogenesis and genetics of psoriasis.
Marsal et al., Barcelona, Spain. In Actas Dermosifiliogr, 2014
Most of these genes can be incorporated into an integrated pathogenic model of psoriatic disease comprising distinct signaling networks affecting skin barrier function (LCE3, DEFB4, GJB2), innate immune responses involving nuclear factor-κB signaling (TNFAIP3, TNIP1, NFKBIA, REL, FBXL19, TYK2, NOS2, CARD14), and adaptive immune responses involving CD8 T cells and interleukin 23 (IL-23)/IL-17-mediated lymphocyte signaling (HLA-C, IL12B, IL23R, IL23A, TRAF3IP2, ERAP1).
Correlating multiallelic copy number polymorphisms with disease susceptibility.
White et al., Melbourne, Australia. In Hum Mutat, 2013
Associations have indeed been described for several genes, including the β-defensins (DEFB4, DEFB103, DEFB104), chemokine ligand 3 like 1 (CCL3L1), Fc gamma receptor 3B (FCGR3B), and complement component C4 (C4).
Copy number variation in autoimmunity--importance hidden in complexity?
Holmdahl et al., Stockholm, Sweden. In Eur J Immunol, 2012
Nonetheless, CNVs in FCGR3B, DEFB4, CCL3L1, C4A/B and NCF1 have been suggested to be associated with autoimmune diseases, although there is conflicting evidence in all cases.
Expression of β-defensin-4 in "an in vivo and ex vivo model" of human osteoarthritic knee meniscus.
Loreto et al., Catania, Italy. In Knee Surg Sports Traumatol Arthrosc, 2012
Data suggest an activation of b-defensin-4 induction, in human knee meniscus by the osteoarthritis inflammatory process as a result of an endogenous antibiotic defense mechanism accompanied by an intrinsic effort of tissue remodeling.
Copy number variation of β-defensin genes in Behçet's disease.
Lee et al., Seoul, South Korea. In Clin Exp Rheumatol, 2011
Our results suggest that copy number variation of DEFB4 may not contribute to the pathogenesis of Behcet's disease.
Production of bioactive human beta-defensin-4 in Escherichia coli using SUMO fusion partner.
Zhang et al., Nanjing, China. In Protein J, 2010
We report here the application of small ubiquitin-related modifier (SUMO) fusion technology to the expression and purification of cationic antibacterial peptide hBD4.
Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2.
Hehlgans et al., Frederick, United States. In J Immunol, 2010
beta-defensin 4 and 14 contribute to the innate and adaptive immune response in their role as chemoattractants
Polymorphisms of beta defensins are associated with the risk of severe acute pancreatitis.
Mándi et al., Szeged, Hungary. In Pancreatology, 2009
The variations in the genes encoding human beta-defensin-1 and -2 may be associated with the risk of severe acute pancreatitis.
Human defensins.
Korting et al., München, Germany. In J Mol Med (berl), 2005
Recently, two novel human beta-defensins, human beta-defensin-3 (HBD-3), and human beta-defensin-4 (HBD-4) have been discovered.
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