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Keratin 85

HB-5, K85, hHb5
The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, Barr, HAD, CAN, hHb1
Papers on HB-5
Is There a Relationship Between Bell's Palsy and Internal Auditory Canal?
Sanli et al., İstanbul, Turkey. In Indian J Otolaryngol Head Neck Surg, Sep 2015
Initial House-Brackmann (HB) score was HB-2 in 29 patients (45.3 %), HB-3 in 18 patients (28.1 %), HB-4 in 13 patients (20.3 %) and HB-5 in 4 patients (6.2 %).
The proteomics of wool fibre morphogenesis.
Scobie et al., Christchurch, New Zealand. In J Struct Biol, Sep 2015
Gel-free proteomic analysis of dissected portions from 30 follicles showed that the first keratins to appear were K31, K35 and K85, in the bulb portion.
Invasive onychocytic carcinoma.
Wang et al., Xi'an, China. In J Cutan Pathol, May 2015
Focal expression of hair-specific keratins, including K31, K85 and K86, was observed.
Specific aptamer-conjugated mesoporous silica-carbon nanoparticles for HER2-targeted chemo-photothermal combined therapy.
Huang et al., Harbin, China. In Acta Biomater, Apr 2015
In this work, a new HB5 aptamer-functionalized mesoporous silica-carbon based doxorubicin (DOX)-loaded system (MSCN-PEG-HB5/DOX) was successfully constructed and characterized for chemo-photothermal combined therapy of human epithelial growth factor receptor 2 (HER2)-positive breast cancer cells.
The ubiquitin E3 ligase SCF-FBXO24 recognizes deacetylated nucleoside diphosphate kinase A to enhance its degradation.
Mallampalli et al., Guangzhou, China. In Mol Cell Biol, Mar 2015
SCF-FBXO24 polyubiquitinates NDPK-A at K85, and two NH(2)-terminal residues, L55 and K56, were identified as important molecular sites for FBXO24 interaction.
Ubiquitination of the transcription factor c-MAF is mediated by multiple lysine residues.
Mao et al., Suzhou, China. In Int J Biochem Cell Biol, 2014
Bioinformatics and computing analyses revealed that K85 and K350 could mediate c-MAF ubiquitination, which was confirmed by the cell-based assays.
Rice (Oryza) hemoglobins.
Sarath et al., Ecatepec, Mexico. In F1000res, 2013
At the molecular level, a family of the nshb genes, consisting of hb1, hb2, hb3, hb4 and hb5, and a single copy of the thb gene exist in Oryza sativa var.
In vitro assembly properties of human type I and II hair keratins.
Ando et al., Saga, Japan. In Cell Struct Funct, 2013
In this study, recombinant proteins of human type I hair keratins (K35, K36 and K38) and type II hair keratins (K81 and K85) were prepared using bacterial expression systems.
Synergistic combination of valproic acid and oncolytic parvovirus H-1PV as a potential therapy against cervical and pancreatic carcinomas.
Marchini et al., Heidelberg, Germany. In Embo Mol Med, 2013
At the molecular level, we found acetylation of the parvovirus nonstructural protein NS1 at residues K85 and K257 to modulate NS1-mediated transcription and cytotoxicity, both of which are enhanced by VPA treatment.
Bidirectional binding property of high glycine-tyrosine keratin-associated protein contributes to the mechanical strength and shape of hair.
Tsumoto et al., Tokyo, Japan. In J Struct Biol, 2013
To clarify the function as well as the binding partners of HGT KAPs, we prepared KAP8.1 and other KAP family proteins, the trichocyte intermediate filament proteins (IFP) K85 and K35, the head domain of K85, and the C subdomain of desmoplakin C-terminus (DPCT-C) and investigated the interactions between them in vitro.
Transcriptional repression of BODENLOS by HD-ZIP transcription factor HB5 in Arabidopsis thaliana.
Jürgens et al., Tübingen, Germany. In J Exp Bot, 2013
Here, it was shown that the HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP) transcription factor HOMEOBOX PROTEIN 5 (HB5) negatively regulates BDL expression, which may contribute to the spatial control of BDL expression.
Turn-directed α-β conformational transition of α-syn12 peptide at different pH revealed by unbiased molecular dynamics simulations.
Cao et al., Dezhou, China. In Int J Mol Sci, 2012
Turn9-6 and four hydrogen bonds (HB9-6, HB6-9, HB11-4 and HB4-11) are formed at physiological pH; turn8-5 and five hydrogen bonds (HB8-5, HB5-8, HB10-3, HB3-10 and HB12-1) are formed at acidic pH.
Identification of novel transcription factors regulating secondary cell wall formation in Arabidopsis.
Grima-Pettenati et al., Toulouse, France. In Front Plant Sci, 2012
Three others (myb52, myb-like TF, hb5) showed hyperlignified SCW whereas the last one (hb15) showed ectopic lignification.
Keratin gene mutations in disorders of human skin and its appendages.
Mukhtar et al., Madison, United States. In Arch Biochem Biophys, 2011
Examples include epidermolysis bullosa simplex (EBS; K5, K14), keratinopathic ichthyosis (KPI; K1, K2, K10) i.e. epidermolytic ichthyosis (EI; K1, K10) and ichthyosis bullosa of Siemens (IBS; K2), pachyonychia congenita (PC; K6a, K6b, K16, K17), epidermolytic palmo-plantar keratoderma (EPPK; K9, (K1)), monilethrix (K81, K83, K86), ectodermal dysplasia (ED; K85) and steatocystoma multiplex.
Autosomal recessive pure hair and nail ectodermal dysplasia linked to chromosome 12p11.1-q14.3 without KRTHB5 gene mutation.
Dahl et al., Faisalābād, Pakistan. In Eur J Dermatol, 2010
Our study confirms linkage of a variant clinical form of hair-nail ectodermal dysplasia to chromosome 12 without any mutation in the coding sequences of the KRTHB5 gene.
Mutations in the keratin 85 (KRT85/hHb5) gene underlie pure hair and nail ectodermal dysplasia.
Christiano et al., In J Invest Dermatol, 2010
crucial role of K85 in keratinization of hair and nails as shown by homozygous mutations in families
Transcriptional activation of a subset of hair keratin genes by the NF-kappaB effector p65/RelA.
Gat et al., Jerusalem, Israel. In Differentiation, 2008
Transfected p65 induces transcriptional activation of Hb5.
A mutation in the hair matrix and cuticle keratin KRTHB5 gene causes ectodermal dysplasia of hair and nail type.
Ahmad et al., In J Med Genet, 2006
Direct evidence relating to the molecular pathogenesis of pure hair-nail ectodermal dysplasias with KRTHB5 gene mutation.
Vertical transmission of hepatitis B antigen in Taiwan.
Lee et al., In N Engl J Med, 1975
To determine the frequency of vertical transmission of hepatitis B antigen (HB5 Ag) from asymptomatic carrier mothers in Taiwan to their offspring, HB5 Ag was sought by radioimmunoassay and complement fixation.
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