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Hyaluronan synthase 3

HAS3, hyaluronan synthase 3
The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: HAS1, CD44, ACID, HAD, POLYMERASE
Papers using HAS3 antibodies
Collagen I–mediated up-regulation of N-cadherin requires cooperative signals from integrins and discoidin domain receptor 1
Johnson Keith R. et al., In The Journal of Cell Biology, 2002
... Anti–c-Jun rabbit pAb and anti–human integrin α2 mouse mAb (HAS3) were obtained from Cell Signaling Technology ...
Papers on HAS3
PP2B and ERK1/2 regulate hyaluronan synthesis of HT168 and WM35 human melanoma cell lines.
Zákány et al., Debrecen, Hungary. In Int J Oncol, Jan 2016
HAS2 and HAS3 were detected in all the samples, while the expression of HAS1 was not detectable in any case.
Hyaluronan stimulates pancreatic cancer cell motility.
Sato et al., Kitakyūshū, Japan. In Oncotarget, Jan 2016
The changes in HA production by these treatments tended to be associated with changes in HAS3 mRNA expression.
Hyaluronan synthases and hyaluronidases in nasal polyps.
Mastronikolis et al., Pátrai, Greece. In Eur Arch Otorhinolaryngol, Jan 2016
Moreover, HAS2 and HAS3 were the only hyaluronan synthases detected, the expression of which was almost similar in NPs and NM.
The ubiquitous hyaluronan: Functionally implicated in the oviduct?
Alvarez-Rodriguez et al., Linköping, Sweden. In Theriogenology, Jan 2016
This fluid contains fluctuating levels of hyaluronan, which is synthesized by the lining epithelium by hyaluronan synthase 3.
A novel epigenetic mechanism regulating hyaluronan production in pancreatic cancer cells.
Hirata et al., Kitakyūshū, Japan. In Clin Exp Metastasis, Dec 2015
This enhanced HA production by 5-aza-dC treatment was accompanied by increased mRNA expression of HAS2 and HAS3.
Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia.
Fischer et al., Düsseldorf, Germany. In Arterioscler Thromb Vasc Biol, Dec 2015
HA is synthesized by 3 different HA synthases (HAS1, HAS2, and HAS3).
Microneedle fractional radiofrequency increases epidermal hyaluronan and reverses age-related epidermal dysfunction.
Lee et al., South Korea. In Lasers Surg Med, Oct 2015
Gene expressions of CD 44, HABP4, and HAS3 were measured using real time RT-PCR.
Biology of hyaluronan: Insights from genetic disorders of hyaluronan metabolism.
Natowicz et al., Winnipeg, Canada. In World J Biol Chem, Sep 2015
Its levels are determined, in part, by the hyaluronan synthases, HAS1, HAS2, and HAS3, and three hyaluronidases, HYAL1, HYAL2 and HYAL3.
[The expression and clinical significance of hyaluronan synthase in nasal polyps].
Liu et al., In Lin Chuang Er Bi Yan Hou Ke Za Zhi, Jun 2015
METHOD: The expression of HA, HAS1, HAS2 and HAS3 in nasal polyps group (25 cases) and inferior turbinate group (15 cases) was detected by immunohistochemistry and semi-quantitative RT-PCR.
Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model.
de la Motte et al., Cleveland, United States. In Int J Cell Biol, 2014
In this study, we tested the progression of inflammation in mice null for the hyaluronan synthase genes (HAS1, HAS3, or both HAS1 and HAS3) in the DSS-colitis model.
The porcine sperm reservoir in relation to the function of hyaluronan.
Tienthai, Bangkok, Thailand. In J Reprod Dev, 2014
It is interesting to note that HA is synthesized by hyaluronan synthase-3 (HAS-3), and its receptor, CD44, is found in the epithelium of the porcine SR site.
Hyaluronan synthase 1: a mysterious enzyme with unexpected functions.
Rilla et al., Kuopio, Finland. In Front Immunol, 2014
Interest in HAS1 has been limited because its role in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity.
Correlative Light and Electron Microscopy Reveals the HAS3-Induced Dorsal Plasma Membrane Ruffles.
Koistinen et al., Kuopio, Finland. In Int J Cell Biol, 2014
We have previously found that overexpression of HAS3 induces growth of long plasma membrane protrusions that act as platforms for hyaluronan synthesis.
Hyaluronan synthase 3 variant and anthracycline-related cardiomyopathy: a report from the children's oncology group.
Bhatia et al., Milwaukee, United States. In J Clin Oncol, 2014
RESULTS: By using a matched case-control design (93 cases, 194 controls), we identified a common SNP, rs2232228, in the hyaluronan synthase 3 (HAS3) gene that exerts a modifying effect on anthracycline dose-dependent cardiomyopathy risk (P = 5.3 × 10(-7)).
Aberrant posttranscriptional processing of hyaluronan synthase 1 in malignant transformation and tumor progression.
Pilarski et al., Boston, United States. In Adv Cancer Res, 2013
HAS1Vs form heterogeneous multimers with normally spliced HAS1 as well as with each other and with HAS3.
Enhanced inflammation and accelerated wound closure following tetraphorbol ester application or full-thickness wounding in mice lacking hyaluronan synthases Has1 and Has3.
Maytin et al., Cleveland, United States. In J Invest Dermatol, 2012
Selective loss of Has1 and Has3 leads to a proinflammatory milieu that favors recruitment of neutrophils and other inflammation-related changes in the dermis.
Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility.
Acott et al., Portland, United States. In Invest Ophthalmol Vis Sci, 2011
HA chains synthesized by HAS1 and HAS2 contribute to outflow resistance, while hyaluronan produced by HAS3 does not appear to play a significant role.
Nodular basal cell carcinoma is associated with increased hyaluronan homeostasis.
Papakonstantinou et al., Thessaloníki, Greece. In J Eur Acad Dermatol Venereol, 2011
Nodular basal cell carcinoma is associated with increased levels of hyaluronic acid concomitant with upregulation of gene expression of HAS3, HYAL3 and RHAMM, when compared with normal adjacent skin.
Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.
Fischer et al., Düsseldorf, Germany. In Mol Cancer, 2010
Data show that mRNA of HAS isoform 3 (HAS3) was upregulated in ESCC biopsies.
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma.
Anttila et al., Kuopio, Finland. In Bmc Cancer, 2009
Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma
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