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Hyaluronan and proteoglycan link protein 4

HAPLN4, Bral2
Top mentioned proteins: SPINK5, Aggrecan, DRS, tenascin-R, NET
Papers on HAPLN4
Identification of candidate genes for familial early-onset essential tremor.
Clark et al., New York City, United States. In Eur J Hum Genet, Nov 2015
HAPLN4 (BRAL2) and USP46.
The chemorepulsive axon guidance protein semaphorin3A is a constituent of perineuronal nets in the adult rodent brain.
Verhaagen et al., Amsterdam, Netherlands. In Mol Cell Neurosci, 2013
PNNs consist of hyaluronan, tenascin-R, chondroitin sulphate proteoglycans (CSPGs), and the link proteins Crtl1 and Bral2.
Mapping the differential distribution of proteoglycan core proteins in the adult human retina, choroid, and sclera.
Bishop et al., Manchester, United Kingdom. In Invest Ophthalmol Vis Sci, 2012
The cartilage link protein HAPLN1 was abundant in the interphotoreceptor matrix and sclera, while HAPLN4 (brain link protein 2) was found throughout the retina and choroid.
Bral2 is indispensable for the proper localization of brevican and the structural integrity of the perineuronal net in the brainstem and cerebellum.
Oohashi et al., Okayama, Japan. In J Comp Neurol, 2012
these results imply that Bral2-brevican interaction may play a key role in synaptic stabilization and the structural integrity of brain perineuronal nets
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 is associated with disease risk and cortical surface area.
Andreassen et al., Oslo, Norway. In Biol Psychiatry, 2011
METHODS: Ten genes of importance for HNK-1 biosynthesis (B3GAT1, B3GAT2, and CHST10) or for the formation of perineuronal nets (TNR, BCAN, NCAN, HAPLN1, HAPLN2, HAPLN3, and HAPLN4) were investigated for potential involvement in schizophrenia (SCZ) susceptibility, by genotyping 104 tagSNPs in the Scandinavian Collaboration on Psychiatric Etiology sample (849 cases; 1602 control subjects).
Reduced expression of the hyaluronan and proteoglycan link proteins in malignant gliomas.
Viapiano et al., Columbus, United States. In J Biol Chem, 2009
Results indicate that HAPLN4 and HAPLN2 are the predominant members of this family in the adult human brain but are strongly reduced in the tumor parenchyma.
Upregulation of aggrecan, link protein 1, and hyaluronan synthases during formation of perineuronal nets in the rat cerebellum.
Fawcett et al., Cambridge, United Kingdom. In J Comp Neurol, 2007
The other link protein that shows a perineuronal net pattern in the DCN, Bral2, is upregulated later during development.
Composition of perineuronal nets in the adult rat cerebellum and the cellular origin of their components.
Fawcett et al., Cambridge, United Kingdom. In J Comp Neurol, 2006
Whereas both net-bearing neurons and glial cells were the sources of CSPGs and tenascin-R, only the neurons expressed the mRNA for HA synthases (HASs), cartilage link protein, and link protein Bral2.
Molecular cloning of Bral2, a novel brain-specific link protein, and immunohistochemical colocalization with brevican in perineuronal nets.
Oohashi et al., Okayama, Japan. In Mol Cell Neurosci, 2003
We report here the molecular cloning and expression analysis of a novel member of LPs: Bral2, predominantly expressed in brain.
A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.
Bowling et al., Houston, United States. In J Biol Chem, 2003
Two of the four link protein genes (HAPLN2 and HAPLN4) were restricted in expression to the brain/central nervous system, while one of the four genes (HAPLN3) was widely expressed.
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