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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

SAM domain, SH3 domain and nuclear localization signals 1

HACS1, SAMSN1, SH3-SAM adaptor protein, Nash1, SAM domain, SH3 domain and nuclear localisation signals 1, SASH2
SAMSN1 is a member of a novel gene family of putative adaptors and scaffold proteins containing SH3 and SAM (sterile alpha motif) domains (Claudio et al., 2001 [PubMed 11536050]).[supplied by OMIM, Mar 2008] (from NCBI)
Top mentioned proteins: AGE, ACID, Src, POLYMERASE, CAN
Papers on HACS1
Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma.
Kodera et al., Nagoya, Japan. In Ann Surg Oncol, Dec 2015
METHODS: We focused here on SAM domain, SH3 domain, and nuclear localization signals 1 (SAMSN1) and investigated expression and methylation status of SAMSN1 in HCC cell lines and 144 pairs of surgical specimens.
SAMSN1 is a tumor suppressor gene in multiple myeloma.
Zannettino et al., Adelaide, Australia. In Neoplasia, 2014
In this study, we identify a Samsn1 gene deletion in the 5TGM1/C57BL/KaLwRij murine model of myeloma.
SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
Lu et al., Shanghai, China. In Plos One, 2012
OBJECTIVES: To study the expression pattern and prognostic significance of SAMSN1 in glioma.
Comparison of immunological characteristics of peripheral, splenic and tonsilar naïve B cells by differential gene expression meta-analyses.
Ruxrungtham et al., Bangkok, Thailand. In Asian Pac J Allergy Immunol, 2012
These included enhanced expressions of CD27, CR2, EGR1, GADD45B, ICAM1, ICOSLG, IGHA, IL6, MMP9, SAMSN1, SMAD7, TNFAIP3, but reduced HLA-DOB expression.
Translocation t(11;14) (q13;q32) and genomic imbalances in multi-ethnic multiple myeloma patients: a Malaysian study.
Zakaria et al., Kuala Lumpur, Malaysia. In Hematol Rep, 2012
Genes located in the chromosomal aberration regions in our study, such as NAMPT, IVNS1ABP, IRF2BP2, PICALM, STAT1, STK17B, FBXL5, ACSL1, LAMP2, SAMSN1 and ATP8B4 might be potential prognostic markers and therapeutic targets in the treatment and management of multiple myeloma patients positive for BCL1/JH t(11;14) (q13;q32) translocation.
Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis.
Nagawa et al., Tokyo, Japan. In Clin Colorectal Cancer, 2011
RESULTS: We identified 20 genes showing differential expression in UC-Ca and UC-NonCa patients, including cancer-related genes such as CYP27B1, RUNX3, SAMSN1, EDIL3, NOL3, CXCL9, ITGB2, and LYN.
Immunoinhibitory adapter protein Src homology domain 3 lymphocyte protein 2 (SLy2) regulates actin dynamics and B cell spreading.
Beer-Hammer et al., Düsseldorf, Germany. In J Biol Chem, 2011
the immunoinhibitory roles of SLy2 in vivo and suggest that the physiological up-regulation of SLy2 observed upon B cell activation functions to counteract excessive B cell spreading.
Error tolerant NMR backbone resonance assignment and automated structure generation.
Li et al., Waterloo, Canada. In J Bioinform Comput Biol, 2011
The final models have backbone RMSDs of 1.25Å, 0.88Å, 1.49Å, and 0.67Å to the reference native structures for proteins TM1112, CASKIN, VRAR, and HACS1, respectively.
SLy2 targets the nuclear SAP30/HDAC1 complex.
Beer-Hammer et al., Düsseldorf, Germany. In Int J Biochem Cell Biol, 2010
In the nucleus, SLy2 interacts with the SAP30/HDAC1 complex and regulates the activity of HDAC1.
Enhanced adaptive immunity in mice lacking the immunoinhibitory adaptor Hacs1.
Wen et al., Toronto, Canada. In Faseb J, 2010
This study suggests that Hacs1 is an immunoinhibitory adaptor that might be a useful target for immune suppression therapy.
Molecular profiles of schizophrenia in the CNS at different stages of illness.
Thomas et al., Los Angeles, United States. In Brain Res, 2008
While only four genes, SAMSN1, CDC42BPB, DSC2 and PTPRE, were consistently expressed across all groups, there was dysfunction in overlapping systems among all stages, including cellular signal transduction, lipid metabolism and protein localization.
Detailed characterization of a homozygously deleted region corresponding to a candidate tumor suppressor locus at 21q11-21 in human lung cancer.
Takahashi et al., Nagoya, Japan. In Genes Chromosomes Cancer, 2008
downregulation of SAMSN1 gene in human lung cancer.
Monoallelic expression of nine imprinted genes in the sheep embryo occurs after the blastocyst stage.
Young et al., Nottingham, United Kingdom. In Reproduction, 2008
Contrary to the trophoblast-restricted maternal expression in both mouse and human, SASH2 (sheep homologue of Mash2/HASH2) was expressed in the ovine foetus and was biallelically expressed in the chorioallantois.
Gene dosage change of TPTE and BAGE2 and breakpoint analysis in Robertsonian Down syndrome.
Hsieh et al., Taiwan. In J Hum Genet, 2007
We further used real-time PCR to detect the copy number of TPTE and BAGE2 located on 21p11 and SAMSN1 on 21q11.
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease.
Takeda et al., Suita, Japan. In Hum Mol Genet, 2007
Logistic regression analysis with age, sex and apolipoprotein E (APOE)-epsilon4 dose supported genetic risk of 17 markers, of which eight markers were linked to the SAMSN1, PRSS7, NCAM2, RUNX1, DYRK1A and KCNJ6 genes.
The SH3-SAM adaptor HACS1 is up-regulated in B cell activation signaling cascades.
Stewart et al., Toronto, Canada. In J Exp Med, 2004
HACS1 is up-regulated by B cell activation signals and is a participant in B cell activation and differentiation.
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