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A kinase

H21, AKAP79, AKAP150
The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein binds to the RII-beta regulatory subunit of PKA, and also to protein kinase C and the phosphatase calcineurin. It is predominantly expressed in cerebral cortex and may anchor the PKA protein at postsynaptic densities (PSD) and be involved in the regulation of postsynaptic events. It is also expressed in T lymphocytes and may function to inhibit interleukin-2 transcription by disrupting calcineurin-dependent dephosphorylation of NFAT. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: CAN, V1a, ACID, PP2B, TRPV1
Papers on H21
Mechanisms and dynamics of AKAP79/150-orchestrated multi-protein signalling complexes in brain and peripheral nerve.
Shapiro et al., San Antonio, United States. In J Physiol, Feb 2016
With the extensive studies of AKAP79/150 in regulation of ion channel activity, the major questions to be posed centre on the mechanism and functional role of synergistic regulation of ion channels by such signalling proteins.
AKAP150 participates in calcineurin/NFAT activation during the down-regulation of voltage-gated K(+) currents in ventricular myocytes following myocardial infarction.
Scott et al., Davis, United States. In Cell Signal, Jan 2016
Here we test the hypothesis that sequestering of calcineurin to the sarcolemma of ventricular myocytes by the anchoring protein AKAP150 is required for acute activation of NFATc3 and the concomitant down-regulation of Kv channels following MI.
Modified sympathetic nerve regulation in AKAP5-null mice.
Murakami et al., Hirosaki, Japan. In Biochem Biophys Res Commun, Jan 2016
AKAP5, also known as AKAP79/150, is an anchoring protein between PKA and voltage-dependent calcium channels, ryanodine receptor-2, phospholamban and other molecules.
A-kinase anchoring protein 79/150 coordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons.
Jeske et al., San Antonio, United States. In Pain, Nov 2015
Herein, we identify that scaffolding protein A-kinase anchoring protein 79/150 (AKAP150) coordinates increased peripheral thermal sensitivity after group I metabotropic receptor (mGluR5) activation.
M-current preservation contributes to anticonvulsant effects of valproic acid.
Hoshi et al., In J Clin Invest, Nov 2015
We also determined that VPA treatment interferes with M-channel signaling by inhibiting palmitoylation of a signaling scaffold protein, AKAP79/150, in cultured neurons.
Histone Deacetylase Inhibition Rescues Maternal Deprivation-Induced GABAergic Metaplasticity through Restoration of AKAP Signaling.
Nugent et al., Bethesda, United States. In Neuron, Jul 2015
Using a single 24-hr episode of MD and whole-cell patch clamp recording in rat midbrain slices, we show that MD selectively induces long-term depression (LTD) and shifts spike timing-dependent plasticity (STDP) toward LTD at GABAergic synapses onto VTA DA neurons through epigenetic modifications of postsynaptic scaffolding A-kinase anchoring protein 79/150 (AKAP79/150) signaling.
Identification of Ganglioside GM3 Molecular Species in Human Serum Associated with Risk Factors of Metabolic Syndrome.
Inokuchi et al., Sendai, Japan. In Plos One, 2014
The hydroxylated GM3 species were, in order of decreasing abundance, d18:1-h24:0 ≈ d18:1-h24:1 > d18:1-h22:0 » d18:1-h20:0 > d18:1-h21:0 > d18:1-h18:1.
AKAP5 signaling complexes: focal points and functional properties.
Zhao et al., Jinan, China. In Neuro Endocrinol Lett, 2014
As a typical member, AKAP5 which consisting of three orthologues: bovine AKAP75, rodent AKAP150 and human AKAP79, is the best known model in the anchoring and targeting properties.
Curcumin Protects Neurons from Glutamate-Induced Excitotoxicity by Membrane Anchored AKAP79-PKA Interaction Network.
Li et al., Beijing, China. In Evid Based Complement Alternat Med, 2014
As a signal integrator which binds to AMPA receptor, A-kinase anchoring protein 79-(AKAP79-) PKA complex is regarded as a potential drug target to exert neuroprotective effects.
Scaffolding builds to reduce blood pressure.
Garland et al., Oxford, United Kingdom. In Sci Signal, 2013
In this issue of Science Signaling, Sonkusare et al. report that the scaffold protein AKAP150 is required for the kinase PKC and the calcium channel TRPV4 to enable receptor-mediated relaxation signaling.
Andersson et al., London, United Kingdom. In Handb Exp Pharmacol, 2013
AKAP79/150) are important for TRPV1 phosphorylation.
CaV1.2 sparklets in heart and vascular smooth muscle.
Santana et al., Davis, United States. In J Mol Cell Cardiol, 2013
CaV1.2 sparklet activity is tightly regulated by a cohort of protein kinases and phosphatases that are targeted to specific regions of the sarcolemma by the anchoring protein AKAP150.
AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin.
Seidenbecher et al., Magdeburg, Germany. In J Neurochem, 2012
We demonstrate that calmodulin and caldendrin compete for a partially overlapping binding site on AKAP79 and that their binding is differentially dependent on calcium
Activation of NMDA receptors leads to phosphorylation of TRPV1 S800 by protein kinase C and A-Kinase anchoring protein 150 in rat trigeminal ganglia.
Ro et al., Baltimore, United States. In Biochem Biophys Res Commun, 2012
NMDA receptor, AKAP150, and TRPV1 forms a signaling complex that underlies the sensitization of trigeminal nociceptors by modulating phosphorylation of specific TRPV1 residues.
Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms.
Dell'acqua et al., Aurora, United States. In J Neurosci, 2012
reults reveal novel roles for the AKAP79/150 signaling complex in dendritic endosomes.
Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling.
Hogan et al., Boston, United States. In Nat Struct Mol Biol, 2012
show that an IAIIIT anchoring site in human AKAP79 binds the same surface of calcineurin as the PxIxIT recognition peptide of NFAT, albeit more strongly
Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8.
Cooper et al., Cambridge, United Kingdom. In J Biol Chem, 2011
Mutation of the two critical cysteines results in exclusion of AKAP79 from lipid rafts and alterations in its membrane diffusion behavior and is accompanied by a loss of the ability of AKAP79 to regulate AC8.
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity.
Scott et al., Portland, United States. In Nat Cell Biol, 2005
The A-kinase anchoring protein AKAP79/150 is a multivalent scaffolding protein that coordinates the subcellular localization of second-messenger-regulated enzymes, such as protein kinase A, protein kinase C and protein phosphatase 2B.
Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein.
Scott et al., Portland, United States. In Science, 1996
Similarly, in mammalian cells the cyclic adenosine 3',5'-monophosphate-dependent protein kinase (PKA) and phosphatase 2B [calcineurin (CaN)] are complexed by an A kinase anchoring protein, AKAP79.
Association of protein kinase A and protein phosphatase 2B with a common anchoring protein.
Scott et al., Portland, United States. In Science, 1995
In neurons, adenosine 3', 5'-monophosphate (cAMP)-dependent protein kinase (PKA) is localized at postsynaptic densities by association of its regulatory subunit with an A kinase anchor protein, AKAP79.
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