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Calponin 2

h2-calponin, Cnn2, calponin 2
The protein encoded by this gene, which can bind actin, calmodulin, troponin C, and tropomyosin, may function in the structural organization of actin filaments. The encoded protein could play a role in smooth muscle contraction and cell adhesion. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: SM22alpha, Actin, H1, HAD, TM3
Papers on h2-calponin
[Application of gene microarray to screen differential expression genes of Modic changes at vertebral endplates].
Cao et al., Linhai, China. In Zhonghua Yi Xue Za Zhi, Sep 2015
The qRT-PCR analysis of 2 up-regulated genes (CXCL14, KCNMA1) and 4 under-regulated genes (MARCKS, ZEB2, PSMF1, and CNN2) mRNA expression levels validated the results from the microarray analysis.
A novel role of h2-calponin in regulating whole blood thrombosis and platelet adhesion during physiologic flow.
Jin et al., Detroit, United States. In Physiol Rep, 2015
The h2-calponin isoform is expressed in myeloid-derived peripheral blood monocytes, where it regulates adhesion.
The potential role of DNA methylation in abdominal aortic aneurysms.
Tromp et al., United States. In Int J Mol Sci, 2014
Principal component analysis and linear analysis of CpG island subsets identified four regions with significant differences in methylation with respect to AAA: kelch-like family member 35 (KLHL35), calponin 2 (CNN2), serpin peptidase inhibitor clade B (ovalbumin) member 9 (SERPINB9), and adenylate cyclase 10 pseudogene 1 (ADCY10P1).
Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol.
Kim et al., Winnipeg, Canada. In Bmc Genomics, 2014
Genes over-expressed in control cells compared to those treated with DMIOA include those involved in cell-to-cell signaling and interaction (IL6, CNN2, ITGB3), cellular assembly and organization (BMP6, IGF1, ACTB), and cell cycle (CD4, 9, 38).
Annexin A2 participates in human skin keloid formation by inhibiting fibroblast proliferation.
Kim et al., Ch'ŏngju, South Korea. In Arch Dermatol Res, 2014
Collagen alpha 1(V) chain precursor, collagen alpha 1(I) chain precursor, ferritin light subunit, alpha 1(III) collagen, 6-phosphogluconolactonase, and calponin 2 were up-regulated.
Mechanoregulation of h2-calponin gene expression and the role of Notch signaling.
Jin et al., Detroit, United States. In J Biol Chem, 2014
We previously demonstrated that the gene encoding h2-calponin (Cnn2) is sensitively regulated by mechanical tension.
Changes in the expression of smooth muscle contractile proteins in TNBS- and DSS-induced colitis in mice.
Murthy et al., Richmond, United States. In Inflammation, 2013
Expression of h-caldesmon, h2-calponin, α-tropomyosin, and smoothelin-A was measured by qRT-PCR and Western blot.
Diminished expression of h2-calponin in prostate cancer cells promotes cell proliferation, migration and the dependence of cell adhesion on substrate stiffness.
Jin et al., Detroit, United States. In Febs Open Bio, 2013
Here we report significant expression of h2-calponin in prostate epithelial cells, which is diminished in cancerous cells.
Androgen-responsive serum response factor target genes regulate prostate cancer cell migration.
Heemers et al., Buffalo, United States. In Carcinogenesis, 2013
Here, the contribution of two representative SRF effector genes that are underexpressed, calponin 2 (CNN2), or overexpressed, sidekick-homolog 1 (SDK1), in clinical CaP specimens is studied.
Calponin 2 acts as an effector of noncanonical Wnt-mediated cell polarization during neural crest cell migration.
Blum et al., Stuttgart, Germany. In Cell Rep, 2013
We found that the actin binding protein calponin 2 (Cnn2) was expressed in protrusions at the leading edge of migratory NCCs in chicks and frogs.
In vitro evaluation of the effectiveness of new water-stable cationic carbosilane dendrimers against Acanthamoeba castellanii UAH-T17c3 trophozoites.
Pérez-Serrano et al., Madrid, Spain. In Parasitol Res, 2013
In this paper we examine for the first time the amebicidal activity of the family of cationic dendrimers nG-[Si{(CH(2))(3)N(+)(Me)(Et)(CH(2))(2)NMe(3) (+)}2I(-)]( x ) (where n denotes the generations: zero (n = 0, x = 1), first (n = 1, x = 4), and second (n = 2, x = 8); for simplicity, they were named as 0G-CNN2, 1G-CNN8, and 2G-CNN16, respectively) against Acanthamoeba castellanii UAH-T17c3 trophozoites.
Increased fibroblast functionality on CNN2-loaded titania nanotubes.
Zhao et al., Xi'an, China. In Int J Nanomedicine, 2011
Infection and epithelial downgrowth are major problems associated with maxillofacial percutaneous implants.
Analysis of differentially expressed genes in human rectal carcinoma using suppression subtractive hybridization.
Kim et al., South Korea. In Clin Exp Med, 2011
The genes are ST3 beta-galactoside alpha-2,3-sialyltransferase (ST3GAL5), interferon-induced transmembrane protein 3 (IFITM3), platelet-derived growth factor A-associated protein 1 (PDAP1), AlkB alkylating repair homolog 3 (ALKBH3), nucleoside diphosphate linked moiety X (Nudix)-type motif 14 (NUDT14), calponin 2 (CNN2), mitogen-activated protein kinase 14 (MAPK14), aconitase 1 (ACO1), and selenophosphate synthetase 1 (SEPHS1).
CDK5RAP2 functions in centrosome to spindle pole attachment and DNA damage response.
Gergely et al., Cambridge, United Kingdom. In J Cell Biol, 2010
By disrupting two evolutionarily conserved domains of CDK5RAP2, CNN1 and CNN2, in the avian B cell line DT40, we find that both domains are essential for linking centrosomes to mitotic spindle poles.
Role of H2-calponin in regulating macrophage motility and phagocytosis.
Jin et al., Chicago, United States. In J Biol Chem, 2008
H2-calponin has a role in regulating macrophage motility and phagocytosis
[Microarray analysis of differentially expressed genes in peripheral leucocytes derived from severe preeclampsia and normotensive pregnancies].
Cui et al., Beijing, China. In Zhonghua Fu Chan Ke Za Zhi, 2008
Eighty six up-regulated candidate genes were mainly involved in cysteine metabolism urea cycle and metabolism of amiogroups, proteasome, TGF-beta signaling pathway, and the ratio of calponin2 (CNN2), matrix metallopeptidase 8 (MMP8), V-set and immunoglobulin domain containing 4 (VSIG4), proteasome 26S subunit ATPase 5 (PSMC5) was evidently increased in preeclampsia patients.
A critical role for calponin 2 in vascular development.
Sukhatme et al., Boston, United States. In J Biol Chem, 2006
Plays an important role in the migration of endothelial cells both in vivo and in vitro; its expression is critical for proper vascular development.
Developmentally regulated expression of calponin isoforms and the effect of h2-calponin on cell proliferation.
Jin et al., Cleveland, United States. In Am J Physiol Cell Physiol, 2003
Expressed h2-calponin is associated with actin-tropomyosin microfilaments and may regulate cytokinesis by inhibiting the activity of the actin cytoskeleton.
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