H-rev107 Regulates Cytochrome P450 Reductase Activity and Increases Lipid Accumulation.
Taipei, Taiwan. In Plos One, 2014
H-rev107 is a member of the HREV107 type II tumor suppressor gene family and acts as a phospholipase to catalyze the release of fatty acids from glycerophospholipid. H-rev107 has been shown to play an important role in fat metabolism in adipocytes through the PGE2/cAMP pathway, but the detailed molecular mechanism underlying H-rev107-mediated lipid degradation has not been studied.
Candidate gene expression affects intramuscular fat content and fatty acid composition in pigs.
Nanjing, China. In J Appl Genet, 2013
The IMF content and fatty acid composition of the Longissimus dorsi muscle were measured and correlated with candidate genes mRNA expression (AdPLA, ADRB3, LEPR, MC4R, PPARγ, PPARα, LPL, PEPCK, and SCD).
Effects of lipoic acid on lipolysis in 3T3-L1 adipocytes.
Pamplona, Spain. In J Lipid Res, 2012
Furthermore, LA caused a significant inhibition of adipose-specific phospholipase A2 (AdPLA) protein and mRNA levels in parallel with a decrease in the amount of prostaglandin E(2) released and an increase in cAMP content.
Lipolysis in adipocytes.
Berkeley, United States. In Int J Biochem Cell Biol, 2010
Furthermore, recent identification of AdPLA as the major adipose phospholipase A(2), has led to the discovery of a dominant autocrine/paracrine regulation of lipolysis through PGE(2).