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Fatty acid binding protein 3, muscle and heart

The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: ACID, FABP, HAD, CAN, AGE
Papers on H-FABP
Comparison of risk assessment strategies for not-high-risk pulmonary embolism.
Lankeit et al., Mainz, Germany. In Eur Respir J, Feb 2016
UNASSIGNED: We compared the prognostic performance of the 2014 European Society of Cardiology (ESC) risk stratification algorithm with the previous 2008 ESC algorithm, the Bova score and the modified FAST score (based on a positive heart-type fatty acid-binding protein (H-FABP) test, syncope and tachycardia, modified using high-sensitivity troponin T instead of H-FABP) in 388 normotensive pulmonary embolism patients included in a single-centre cohort study.Overall, 25 patients (6.4%) had an adverse 30-day outcome.
Overexpression of SREBP1 (sterol regulatory element binding protein 1) promotes de novo fatty acid synthesis and triacylglycerol accumulation in goat mammary epithelial cells.
Bionaz et al., China. In J Dairy Sci, Jan 2016
Compared with Ad-GFP cells (control), Ad-nSREBP1 cells had a significant increase in expression of genes related to long-chain fatty acid activation (ACSL1), transport (FABP3), desaturation (SCD1), de novo synthesis of fatty acids (ACSS2, ACLY, IDH1, ACACA, FASN, and ELOVL6), and transcriptional factors (NR1H3 and PPARG).
Heart-type fatty acid binding protein and high-sensitivity troponin T are myocardial damage markers that could predict adverse clinical outcomes in patients with peripheral artery disease.
Kubota et al., Yamagata, Japan. In Bba Clin, Dec 2015
Heart-type fatty acid-binding protein (H-FABP) and high-sensitivity troponin T (hsTnT) are markers of ongoing myocardial damage and have been reported to be useful indicators of future cardiovascular events.
Evaluation of microRNAs-208 and 133a/b as differential biomarkers of acute cardiac and skeletal muscle toxicity in rats.
Tirmenstein et al., New Brunswick, United States. In Toxicol Appl Pharmacol, Dec 2015
Increases in heart specific miR-208 only occurred in rats with cardiac lesions alone and were increased for a longer duration than cardiac troponin and FABP3 (cardiac biomarkers).
Heart-type fatty acid-binding protein (H-FABP) as an early diagnostic biomarker in patients with acute chest pain.
Natarajan et al., India. In Indian Heart J, Nov 2015
BACKGROUND: Heart-type fatty acid-binding protein (H-FABP) is an emerging biomarker, which was found to be sensitive for the early diagnosis of acute myocardial infarction (AMI).
Prognostic Value of Biomarkers in Acute Non-massive Pulmonary Embolism: A Systematic Review and Meta-analysis.
Hosur et al., Scranton, United States. In Lung, Oct 2015
Studies were included if those were done on patients with acute PE and serum troponin or brain natriuretic peptide and N-terminal proBNP (BNP/NT-proBNP) or Heart-type fatty acid-binding protein (H-FABP) assay was done.
Utilization of digital differential display to identify differentially expressed genes related to rumen development.
Roh et al., Nayoro, Japan. In Anim Sci J, Oct 2015
Among the 11 genes, only 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMGCS2), aldo-keto reductase family 1, member C1-like (AKR1C1), and fatty acid binding protein 3 (FABP3) showed significant changes in the levels of gene expression in the rumen between the pre- and post-weaning of calves.
Effect of short-chain fatty acids on triacylglycerol accumulation, lipid droplet formation and lipogenic gene expression in goat mammary epithelial cells.
Loor et al., China. In Anim Sci J, Sep 2015
The expression of FABP3, SCD1, PPARG, SREBP1, DGAT1, AGPAT6 and ADRP were upregulated by propionate and butyrate treatment.
[Echocardiography and Biochemical Examination in the Treatment of Ischemic Heart Disease].
Nakamura et al., In Rinsho Byori, Aug 2015
In the 8 acute myocardial infarction cases, asynergy was noted in all cases on echocardiography, but CK, CK-MB, and H-FABP cardiac biomarkers showed mixed negativity and positivity.
[Clinical Impact of High Sensitive Troponin I Assay].
Sawano et al., In Rinsho Byori, 2015
In the revised STEMI Guidelines, a description was added stating that high sensitive Troponiri assays are superior to all other cardiac markers, including myoglobin, CK-MB, H-FABP, and conventional Troponin assays.
Evaluation of cardiac biomarkers and right ventricular dysfunction in patients with acute pulmonary embolism.
Rota et al., Denizli, Turkey. In Anatol J Cardiol, 2015
Cytoplasmic heart-type fatty acid-binding protein (HFABP) and the N-terminal fragment of its prohormone (NT-proBNP) are sensitive and specific biomarkers of myocardial damage.
PPARα signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle.
Yan et al., Lanzhou, China. In Genet Mol Res, 2014
In yaks, the expression levels of FABP3 (P < 0.05) and LPL (P < 0.01) were negatively correlated with MUFA, and those of FABP4 and SCD were positively correlated with PUFA (P < 0.01).
Beyond the Limits: Clinical Utility of Novel Cardiac Biomarkers.
Dinić et al., Niš, Serbia. In Biomed Res Int, 2014
Studies that evaluate miRNA, H-FABP, and MR-PAMP give encouraging results.
The Impact of Exercising During Haemodialysis on Blood Pressure, Markers of Cardiac Injury and Systemic Inflammation - Preliminary Results of a Pilot Study.
Smith et al., Leicester, United Kingdom. In Kidney Blood Press Res, 2014
No differences in h-FABP, cTnI, myoglobin or CKMB were observed between trial arms.
Identification and evaluation of polymorphisms in FABP3 and FABP4 in beef cattle.
Ferraz et al., Aquidauana, Brazil. In Genet Mol Res, 2014
Single nucleotide polymorphisms (SNPs) were screened in FABP3 and FABP4 by automatic sequencing of pools of DNA from crossbred animals whose phenotypes belonged to the upper and lower extremes for back fat and marbling, as well as of a pool of DNA from sires used for crossbreeding.
Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
Chaves et al., Valencia, Spain. In Plos One, 2011
Common variants of the liver fatty acid binding protein genes 1-4 influence the risk of type 2 diabetes and insulin resistance in Spanish population
Diagnostic accuracy of heart fatty acid binding protein (H-FABP) and glycogen phosphorylase isoenzyme BB (GPBB) in diagnosis of acute myocardial infarction in patients with acute coronary syndrome.
Zaputovic et al., Rijeka, Croatia. In Biochem Med (zagreb), 2011
H-FABP and GPBB can contribute to early acute myocardial infarction diagnosis and can distinguish acute myocardial infarction from acute coronary syndrome
Diagnostic accuracy of quantitative heart-fatty acid binding protein assays compared with Cardiodetect(®) in the early detection of acute coronary syndrome.
Lauque et al., Toulouse, France. In Arch Cardiovasc Dis, 2011
Measurement of h-FABP was insufficient to be used as a marker of acute coronary syndrome and myocardial infarction in hospital emergency department, whatever the analytical technique used.
High sensitive troponin T and heart fatty acid binding protein: novel biomarker in heart failure with normal ejection fraction? A cross-sectional study.
Seyfarth et al., Wuppertal, Germany. In Bmc Cardiovasc Disord, 2010
Levels of highly sensitive troponin T and heart fatty acid binding protein are significantly higher in patients with asymptomatic left ventricular diastolic function and heart failure patients with normal ejection fraction, compared to controls.
Heart fatty acid-binding protein offers similar diagnostic performance to high-sensitivity troponin T in emergency room patients presenting with chest pain.
Daida et al., Nerima, Japan. In Circ J, 2010
H-FABP offers similar overall diagnostic performance, while the combination of H-FABP and MPO assays may improve the diagnosis of ACS, particularly in patients with recent onset of chest pain.
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