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DiGeorge syndrome critical region gene 8

Gy-1, DGCR8
This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010] (from NCBI)
Top mentioned proteins: Ribonuclease III, Dicer, CAN, prolactin receptor, miR
Papers on Gy-1
A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.
Steitz et al., Ensenada, Mexico. In Rna, Feb 2016
During microRNA (miRNA) biogenesis, the Microprocessor complex (MC), composed minimally of Drosha, an RNaseIII enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary-miRNA (pri-miRNA) to release the pre-miRNA stem-loop structure.
Structure of Human DROSHA.
Woo et al., Seoul, South Korea. In Cell, Feb 2016
DROSHA functions together with its cofactor DGCR8 in a heterotrimeric complex known as Microprocessor.
Essential Function of Dicer in Resolving DNA Damage in the Rapidly Dividing Cells of the Developing and Malignant Cerebellum.
Deshmukh et al., Chapel Hill, United States. In Cell Rep, Feb 2016
We report that deletion of Dicer in the developing mouse cerebellum resulted in the accumulation of DNA damage leading to cerebellar progenitor degeneration, which was rescued with p53 deficiency; deletion of DGCR8 also resulted in similar DNA damage and cerebellar degeneration.
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.
Cáceres et al., Copenhagen, Denmark. In Mol Cell, Jan 2016
The Microprocessor complex (DGCR8/Drosha) is required for microRNA (miRNA) biogenesis but also binds and regulates the stability of several types of cellular RNAs.
Design of Effective Primary MicroRNA Mimics With Different Basal Stem Conformations.
Weinberg et al., Johannesburg, South Africa. In Mol Ther Nucleic Acids, Dec 2015
Cleavage of the pri-miRNA to a precursor miRNA (pre-miRNA) by Drosha-DGCR8 typically occurs adjacent to a basal stem of ~11 bp.
Biogenesis and regulation of the let-7 miRNAs and their functional implications.
Lee et al., Taejŏn, South Korea. In Protein Cell, Oct 2015
To generate a let-7 miRNA, a primary transcript is produced by RNA polymerase II and then subsequently processed by Drosha/DGCR8, TUTase, and Dicer.
HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.
Tavazoie et al., New York City, United States. In Cell, Oct 2015
Moreover, HNRNPA2B1 binds to m(6)A marks in a subset of primary miRNA transcripts, interacts with the microRNA Microprocessor complex protein DGCR8, and promotes primary miRNA processing.
Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity.
Anastasiadis et al., Jacksonville, United States. In Nat Cell Biol, Sep 2015
Here, we resolve this apparent paradox by identifying two spatially and functionally distinct junctional complexes in non-transformed polarized epithelial cells: one growth suppressing at the apical zonula adherens (ZA), defined by the p120 partner PLEKHA7 and a non-nuclear subset of the core microprocessor components DROSHA and DGCR8, and one growth promoting at basolateral areas of cell-cell contact containing tyrosine-phosphorylated p120 and active Src.
Functional Anatomy of the Human Microprocessor.
Woo et al., Seoul, South Korea. In Cell, Jul 2015
MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of functional miRNAs.
N6-methyladenosine marks primary microRNAs for processing.
Tavazoie et al., New York City, United States. In Nature, Apr 2015
The first step in the biogenesis of microRNAs is the processing of primary microRNAs (pri-miRNAs) by the microprocessor complex, composed of the RNA-binding protein DGCR8 and the type III RNase DROSHA.
Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis.
Zettl et al., Rostock, Germany. In Mutat Res Rev Mutat Res, 2015
This SNP is suspected to affect the recognition of the primary microRNA hairpin by Drosha and its cofactor DGCR8.
Association of Polymorphic Variants of miRNA Processing Genes with Larynx Cancer Risk in a Polish Population.
Majsterek et al., Warsaw, Poland. In Biomed Res Int, 2014
Nine polymorphisms of pre-miRNA processing genes, DROSHA (rs6877842), DGCR8 (rs3757, rs417309, and rs1640299), RAN (rs14035), XPO5 (rs11077), DICER1 (rs13078 and rs3742330) and TARBP2 (rs784567), were performed by TaqMan SNP Genotyping Assay.
MeCP2: multifaceted roles in gene regulation and neural development.
Qiu et al., Shanghai, China. In Neurosci Bull, 2014
MeCP2 represses nuclear microRNA processing by interacting directly with the Drosha/DGCR8 complex.
TRAIL mediated signaling in pancreatic cancer.
Farooqi et al., Santa Maria, Brazil. In Asian Pac J Cancer Prev, 2013
It has been shown that DR5 interacts with the core microprocessor components Drosha and DGCR8, thus impairing processing of primary let-7.
MicroRNA Machinery Genes as Novel Biomarkers for Cancer.
Liu et al., Wuhan, China. In Front Oncol, 2013
To be able to perform their myriad roles, miRNA machinery genes, such as Drosha, DGCR8, Dicer1, XPO5, TRBP, and AGO2, must generate precise miRNAs.
DGCR8 HITS-CLIP reveals novel functions for the Microprocessor.
Cáceres et al., Edinburgh, United Kingdom. In Nat Struct Mol Biol, 2012
DGCR8-mediated cleavage of snoRNAs was independent of Drosha, suggesting the involvement of DGCR8 in cellular complexes with other endonucleases. Binding of DGCR8 to cassette exons is a new mechanism for regulation of alternatively spliced isoforms.
Loss of microRNAs in pyramidal neurons leads to specific changes in inhibitory synaptic transmission in the prefrontal cortex.
Ullian et al., San Francisco, United States. In Mol Cell Neurosci, 2012
Deletion of Dgcr8 results in a severe deficit in inhibitory synaptic transmission and reduction of inhibitory synapses in pyramidal neurons .
DiGeorge syndrome critical region 8 (DGCR8) protein-mediated microRNA biogenesis is essential for vascular smooth muscle cell development in mice.
Yue et al., Memphis, United States. In J Biol Chem, 2012
DGCR8 gene is required for vascular development through the regulation of VSMC proliferation, apoptosis, and differentiation.
Caspases cleave and inhibit the microRNA processing protein DiGeorge Critical Region 8.
Guo et al., Los Angeles, United States. In Protein Sci, 2012
DGCR8 is cleaved by caspases between Asp396 and Ser397 in HeLa cells.
Ferric, not ferrous, heme activates RNA-binding protein DGCR8 for primary microRNA processing.
Guo et al., Los Angeles, United States. In Proc Natl Acad Sci U S A, 2012
This study demonstrates binding specificity of DGCR8 for ferric heme, provides direct biochemical evidence for ferric heme serving as an activator for miRNA maturation.
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