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Guanylate kinase 1

guanylate kinase
The protein encoded by this gene is an enzyme that catalyzes the transfer of a phosphate group from ATP to guanosine monophosphate (GMP) to form guanosine diphosphate (GDP). The encoded protein is thought to be a good target for cancer chemotherapy. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] (from NCBI)
Top mentioned proteins: PSD-95, CAN, V1a, SAP97, ACID
Papers on guanylate kinase
Characterization of physiologic phenotypes of dentate gyrus synapses of PDZ1/2 domain-deficient PSD-95 knockin mice.
Fujiyoshi et al., Nagoya, Japan. In Eur J Neurosci, Jan 2016
We demonstrated global changes in the PSD membrane-associated guanylate kinase expression pattern in the DG of mutant mice, and DG synapses in these mice exhibited increased long-term potentiation under a wide range of stimulus intensities, although the N-methyl-D-aspartic acid receptor dependence of the long-term potentiation was unchanged.
Molecular pathogenesis of lymphomas of mucosa-associated lymphoid tissue-from (auto)antigen driven selection to the activation of NF-κB signaling.
Liu et al., Shanghai, China. In Sci China Life Sci, Dec 2015
Fusion proteins generated by these translocations share the same NF-κB signaling pathway, which is activated by the caspase activation and recruitment domain containing molecules of the membrane associated guanylate kinase family, B cell lymphoma-10 and MALT1 (CBM) protein complex.
Anchoring and synaptic stability of PSD-95 is driven by ephrin-B3.
Dalva et al., Philadelphia, United States. In Nat Neurosci, Nov 2015
Organization of signaling complexes at excitatory synapses by membrane-associated guanylate kinase (MAGUK) proteins regulates synapse development, plasticity, senescence and disease.
Immunohistochemical study of the membrane skeletal protein, membrane protein palmitoylated 6 (MPP6), in the mouse small intestine.
Terada et al., Matsumoto, Japan. In Histochem Cell Biol, Nov 2015
UNASSIGNED: The membrane protein palmitoylated (MPP) family belongs to the membrane-associated guanylate kinase (MAGUK) family.
PDZ Protein Regulation of G Protein-Coupled Receptor Trafficking and Signaling Pathways.
Ferguson et al., London, Canada. In Mol Pharmacol, Oct 2015
These PDZ domain-containing proteins include the membrane-associated guanylate-like kinases [postsynaptic density protein of 95 kilodaltons; synapse-associated protein of 97 kilodaltons; postsynaptic density protein of 93 kilodaltons; synapse-associated protein of 102 kilodaltons; discs, large homolog 5; caspase activation and recruitment domain and membrane-associated guanylate-like kinase domain-containing protein 3; membrane protein, palmitoylated 3; calcium/calmodulin-dependent serine protein kinase; membrane-associated guanylate kinase protein (MAGI)-1, MAGI-2, and MAGI-3], Na(+)/H(+) exchanger regulatory factor proteins (NHERFs) (NHERF1, NHERF2, PDZ domain-containing kidney protein 1, and PDZ domain-containing kidney protein 2), Golgi-associated PDZ proteins (Gα-binding protein interacting protein, C-terminus and CFTR-associated ligand), PDZ domain-containing guanine nucleotide exchange factors (GEFs) 1 and 2, regulator of G protein signaling (RGS)-homology-RhoGEFs (PDZ domain-containing RhoGEF and leukemia-associated RhoGEF), RGS3 and RGS12, spinophilin and neurabin-1, SRC homology 3 domain and multiple ankyrin repeat domain (Shank) proteins (Shank1, Shank2, and Shank3), partitioning defective proteins 3 and 6, multiple PDZ protein 1, Tamalin, neuronal nitric oxide synthase, syntrophins, protein interacting with protein kinase C α 1, syntenin-1, and sorting nexin 27.
[The role of calcium/calmodulin dependent serine protein kinase in embryonic development and related diseases].
Yuan et al., Nanjing, China. In Zhonghua Yi Xue Yi Chuan Xue Za Zhi, Jun 2015
Calcium/calmodulin dependent serine protein kinase (CASK), which belongs to the family of membrane associated guanylate kinase (MAGUK) proteins, has several isoforms.
MAGI2/S-SCAM outside brain.
Hata et al., Tokyo, Japan. In J Biochem, Apr 2015
Membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains (MAGI)2 (also called synaptic scaffolding molecule (S-SCAM), atrophin-1-interacting protein 1, activin receptor-interacting protein 1) is a scaffold protein that binds a wide variety of receptors, cell adhesion molecules and signalling molecules.
Identification of lung cancer oncogenes based on the mRNA expression and single nucleotide polymorphism profile data.
Chen et al., In Neoplasma, 2014
Besides, PIK3R1 (phosphoinositide-3-kinase, regulatory subunit 1), RORA (RAR-related orphan receptor A), MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3), PTPRM (protein tyrosine phosphatase, receptor type, M), and BMP6 (bone morphogenetic protein 6) were the hub genes in PPI network.
Helicobacter pylori Infection Induces Anemia, Depletes Serum Iron Storage, and Alters Local Iron-Related and Adult Brain Gene Expression in Male INS-GAS Mice.
Fox et al., New York City, United States. In Plos One, 2014
Expression of synaptic plasticity markers (brain derived neurotrophic factor 3 (Bdnf3), Psd95 (a membrane associated guanylate kinase), and insulin-like growth factor 1 (Igf1)) was also downregulated in Hp SS1-infected mice (p = 0.09, p = 0.04, p = 0.02 respectively).
Regulation and involvement in cancer and pathological conditions of MAGI1, a tight junction protein.
Jiang et al., Hohhot, China. In Anticancer Res, 2014
Membrane-associated guanylate kinase with an inverted repeat member 1 (MAGI1), is a member of a family of proteins which are emerging as important in coupling the extracellular environment to intracellular signaling pathways and the cytoskeleton at synapses and tight junctions.
The ß subunit of voltage-gated Ca2+ channels.
Yang et al., New York City, United States. In Physiol Rev, 2010
All four subtypes of Ca(v)β, encoded by different genes, have a modular organization, consisting of three variable regions, a conserved guanylate kinase (GK) domain, and a conserved Src-homology 3 (SH3) domain, placing them into the membrane-associated guanylate kinase (MAGUK) protein family.
Choreography of MAGUKs during T cell activation.
Davis et al., In Nat Immunol, 2007
T cell receptor activation requires the membrane-associated guanylate kinase CARMA1.
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) and guanylate kinase 1 (GUK1) are differentially expressed in GH-secreting adenomas.
Giannella-Neto et al., São Paulo, Brazil. In Pituitary, 2005
HGS and GUK1 were significantly over expressed in GH-secreting adenomas, compared with ACTH-secreting adenomas and nonfunctioning tumors, and with PRL-secreting adenomas, respectively.
mPins modulates PSD-95 and SAP102 trafficking and influences NMDA receptor surface expression.
Wenthold et al., Bethesda, United States. In Nat Cell Biol, 2005
We show that mPins (mammalian homologue of Drosophila melanogaster partner of inscuteable) interacts with SAP102 and PSD-95 (two PDZ proteins present in neurons), and functions in the formation of the NMDAR-MAGUK (N-methyl-D-aspartate receptor-membrane-associated guanylate kinase) complex.
Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels.
Yang et al., New York City, United States. In Nature, 2004
The structures show that the beta-subunit core contains two interacting domains: a Src homology 3 (SH3) domain and a guanylate kinase (GK) domain.
CARMA1 is a critical lipid raft-associated regulator of TCR-induced NF-kappa B activation.
Thome et al., Biel, Switzerland. In Nat Immunol, 2002
CARMA1 is a lymphocyte-specific member of the membrane-associated guanylate kinase (MAGUK) family of scaffolding proteins, which coordinate signaling pathways emanating from the plasma membrane.
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