gopubmed logo
find other proteinsAll proteins
GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Son of sevenless homolog 1

guanine nucleotide exchange factor, SOS1, NS4, SOS2
This gene encodes a protein that is a guanine nucleotide exchange factor for RAS proteins, membrane proteins that bind guanine nucleotides and participate in signal transduction pathways. GTP binding activates and GTP hydrolysis inactivates RAS proteins. The product of this gene may regulate RAS proteins by facilitating the exchange of GTP for GDP. Mutations in this gene are associated with gingival fibromatosis 1 and Noonan syndrome type 4. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GEF, Rhodopsin, V1a, CAN, Actin
Papers using guanine nucleotide exchange factor antibodies
Urokinase-type plasminogen activator binding to its receptor stimulates tumor cell migration by enhancing integrin-mediated signal transduction
Gonias Steven L. et al., In The Journal of Cell Biology, 1998
... Sos1-specific polyclonal antibody (C-23) was from Santa Cruz Biotechnology, Inc ...
BLNK: a central linker protein in B cell activation
Clark Edward A. et al., In The Journal of Experimental Medicine, 1997
... Anti–SLP-76, anti-Grb2, anti–SH2 domain–containing protein tyrosine phosphatase 2 (SHP-2), anti-Sos1, and anti-Sos2 were purchased from Santa Cruz Biotechnology ...
Papers on guanine nucleotide exchange factor
Screening and Characterization of Genes Involved in the Processing of Lipid-Containing Droplets in C. elegans Embryos.
Döring et al., Kiel, Germany. In Genetics, Feb 2016
The genes include cpl-1 (cathepsin L-like cysteine protease), ccz-1 (guanine nucleotide exchange factor subunit), and asm-3 (acid sphingomyelinase), which is closely related to the human Niemann-Pick disease-causing gene, SMPD1.
Inside-Out Signaling Pathways from Nuclear Reactive Oxygen Species Control Pulmonary Innate Immunity.
Brasier et al., Galveston, United States. In J Innate Immun, Feb 2016
The cytoplasmic OGG1:8-oxoG complex functions as a guanine nucleotide exchange factor, triggering small GTPase signaling and activating phosphorylation of the nuclear factor (NF)x03BA;B/RelA transcription factor to induce immediate early gene expression.
SGEF Is Regulated via TWEAK/Fn14/NF-κB Signaling and Promotes Survival By Modulation of the DNA Repair Response to Temozolomide.
Tran et al., Phoenix, United States. In Mol Cancer Res, Feb 2016
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
RASSF1A suppresses the invasion and metastatic potential of human non-small cell lung cancer cells by inhibiting YAP activation through the GEF-H1/RhoB pathway.
Zalcman et al., Caen, France. In Cancer Res, Feb 2016
Mechanistic investigations revealed that RASSF1A blocked tumor growth by stimulating cofilin/PP2A-mediated dephosphorylation of the guanine nucleotide exchange factor GEF-H1, thereby stimulating its ability to activate the anti-metastatic small GTPase RhoB.
Levels of Schistosoma mansoni Circulating Antigen in Chronic Hepatitis C Patients with Different Stages of Liver Fibrosis.
Ismail et al., Damietta, Egypt. In J Immunoassay Immunochem, Feb 2016
A total of 174 CHC patients showing HCV-NS4 antigen and HCV- RNA in their sera were included.
A novel splicing mutation in the IQSEC2 gene that modulates the phenotype severity in a family with intellectual disability.
Mila et al., Barcelona, Spain. In Eur J Hum Genet, Feb 2016
UNASSIGNED: The IQSEC2 gene is located on chromosome Xp11.22 and encodes a guanine nucleotide exchange factor for the ADP-ribosylation factor family of small GTPases.
The pleiotropic role of exchange protein directly activated by cAMP 1 (EPAC1) in cancer: implications for therapeutic intervention.
Cheng et al., Galveston, United States. In Acta Biochim Biophys Sin (shanghai), Jan 2016
Exchange protein directly activated by cAMP 1 (EPAC1) mediates the intracellular functions of cAMP by acting as a guanine nucleotide exchange factor for the Ras-like Rap small GTPases.
Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction.
Brunet et al., Stanford, United States. In Cell Metab, Dec 2015
AMPK phosphorylation of the RHOA guanine nucleotide exchange factor NET1A inhibits extracellular matrix degradation, an early step in cell invasion.
Activator-inhibitor coupling between Rho signalling and actin assembly makes the cell cortex an excitable medium.
von Dassow et al., Madison, United States. In Nat Cell Biol, Nov 2015
The waves are modulated by cyclin-dependent kinase 1 (Cdk1) activity and require the Rho GEF (guanine nucleotide exchange factor), Ect2.
Recent advances in RASopathies.
Matsubara et al., Sendai, Japan. In J Hum Genet, Nov 2015
Recently, novel gene variants, including RIT1, RRAS, RASA2, A2ML1, SOS2 and LZTR1, have been shown to be associated with RASopathies, further expanding the disease entity.
Exome sequencing of desmoplastic melanoma identifies recurrent NFKBIE promoter mutations and diverse activating mutations in the MAPK pathway.
Bastian et al., San Francisco, United States. In Nat Genet, Oct 2015
Instead, other genetic alterations known to activate the MAPK and PI3K signaling cascades were identified in 73% of samples, affecting NF1, CBL, ERBB2, MAP2K1, MAP3K1, BRAF, EGFR, PTPN11, MET, RAC1, SOS2, NRAS and PIK3CA, some of which are candidates for targeted therapies.
Growth Factor FGF2 Cooperates with Interleukin-17 to Repair Intestinal Epithelial Damage.
Qian et al., Shanghai, China. In Immunity, Oct 2015
Act1, an essential adaptor in IL-17 signaling, suppressed FGF2-induced ERK activation through binding to adaptor molecule GRB2 to interfere with its association with guanine nucleotide exchange factor SOS1. Act1 preferentially bound to IL-17 receptor complex, releasing its suppressive effect on FGF2 signaling.
RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth.
Roose et al., San Francisco, United States. In Nat Cell Biol, Jun 2015
Here we show that two distinct Ras nucleotide exchange factors, RasGRP1 and SOS1, lie downstream of EGFR but act in functional opposition.
Salinity tolerance in plants. Quantitative approach to ion transport starting from halophytes and stepping to genetic and protein engineering for manipulating ion fluxes.
Volkov, London, United Kingdom. In Front Plant Sci, 2014
Special attention is given to ion transporters and to potassium and sodium transport by HKT, HAK, NHX, and SOS1 proteins.
Mutation in NRAS in familial Noonan syndrome--case report and review of the literature.
Bondeson et al., Uppsala, Sweden. In Bmc Med Genet, 2014
Comprehensive mutation analysis of NF1, PTPN11, SOS1, CBL, BRAF, RAF1, SHOC2, MAP2K2, MAP2K1, SPRED1, NRAS, HRAS and KRAS was performed using targeted next-generation sequencing.
Deconstructing Ras signaling in the thymus.
Samelson et al., Bethesda, United States. In Mol Cell Biol, 2012
assessed the independent and combined roles for the RasGEFs Sos1, Sos2, and RasGRP1 during thymocyte development
TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
Simeoni et al., Magdeburg, Germany. In Embo Rep, 2012
T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos.
Multivalent binding and facilitated diffusion account for the formation of the Grb2-Sos1 signaling complex in a cooperative manner.
Farooq et al., Miami, United States. In Biochemistry, 2012
multiple binding sites within Sos1 provide a physical route for Grb2 to hop in a flip-flop manner from one site to the next through facilitated diffusion, and such rapid exchange forms the basis of cooperativity driving bivalent binding of Grb2 to Sos1
Extensive gene deletions in Japanese patients with Diamond-Blackfan anemia.
Hamaguchi et al., Tokyo, Japan. In Blood, 2012
Data show 1 proband with an RPL5 deletion, 1 patient with an RPL35A deletion, 3 with RPS17 deletions, and 1 with an RPS19 deletion.
Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2.
Goldstein et al., United States. In Plos One, 2011
Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2
share on facebooktweetadd +1mail to friends