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V-ral simian leukemia viral oncogene homolog B

GTP-Binding Protein, RalB
This gene encodes a GTP-binding protein that belongs to the small GTPase superfamily and Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. [provided by RefSeq, Jul 2008] (from NCBI)
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Top mentioned proteins: CAN, Rhodopsin, V1a, ACID, Ral
Papers using GTP-Binding Protein antibodies
Ral GTPases regulate neurite branching through GAP-43 and the exocyst complex
Hall Alan et al., In The Journal of Cell Biology, 2003
... Antibodies used were mouse anti-RalA, rabbit anti-RalB (BD Biosciences), mouse anti–GAP-43 (Autogen Bioclear), ...
Papers on GTP-Binding Protein
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.
Whiteheart et al., Lexington, United States. In Blood, Feb 2016
ADP-ribosylation factor 6 (Arf6) is a small GTP-binding protein known to regulate endocytic trafficking, especially of integrins.
Guanylate-binding protein 1 (GBP1) promotes lymph node metastasis in human esophageal squamous cell carcinoma.
Liu et al., Beijing, China. In Discov Med, Dec 2015
Guanylate-binding protein 1 (GBP1) is a GTP-binding protein family member with high GTPase activity.
Nucleostemin promotes the proliferation of human glioma via Wnt/β-Catenin pathway.
Cui et al., Suzhou, China. In Neuropathology, Dec 2015
UNASSIGNED: Nucleostemin, nucleolar guanosine triphosphate (GTP)-binding protein 3, is a member of the MMR1/HSR1 GTP-binding protein family.
Identification of mutation in GTPBP2 in patients of a family with neurodegeneration accompanied by iron deposition in the brain.
Elahi et al., Tehrān, Iran. In Neurobiol Aging, Dec 2015
A splice site mutation in GTPBP2 that encodes GTP-binding protein 2 was identified in the patients and considered possible cause of their disease.
2015 ATVB Plenary Lecture: translational research on rho-kinase in cardiovascular medicine.
Satoh et al., Sendai, Japan. In Arterioscler Thromb Vasc Biol, Aug 2015
Rho-kinase (ROCKs) is an important downstream effector of the small GTP-binding protein Ras homolog gene family member A. There are 2 isoforms of ROCK, ROCK1 and ROCK2, and they have different functions in several vascular components.
Modulation of actin dynamics by Rac1 to target cognitive function.
Tejada-Simon, Houston, United States. In J Neurochem, Jun 2015
Less research, however, has been done regarding the role of this small GTP-binding protein in brain development, where it has an important role in dendritic spine morphogenesis through the regulation of actin.
Ral GTPases: crucial mediators of exocytosis and tumourigenesis.
Horiuchi et al., Sendai, Japan. In J Biochem, May 2015
The Ral guanosine triphosphatases (GTPases), RalA and RalB, are members of the Ras superfamily of small GTPases.
The RAS-RAL axis in cancer: evidence for mutation-specific selectivity in non-small cell lung cancer.
Theodorescu et al., Aurora, United States. In Acta Pharmacol Sin, Mar 2015
The RAL GTPase family comprises RALA and RALB, which can have either divergent or similar functions in different tumor models.
Discovery and characterization of small molecules that target the GTPase Ral.
Theodorescu et al., Aurora, United States. In Nature, 2014
The Ras-like GTPases RalA and RalB are important drivers of tumour growth and metastasis.
An integrin β₃-KRAS-RalB complex drives tumour stemness and resistance to EGFR inhibition.
Cheresh et al., San Diego, United States. In Nat Cell Biol, 2014
Mechanistically, α(v)β₃, in the unliganded state, recruits KRAS and RalB to the tumour cell plasma membrane, leading to the activation of TBK1 and NF-κB.
A new function and complexity for protein translation initiation factor eIF2B.
Pavitt et al., Manchester, United Kingdom. In Cell Cycle, 2013
It is a guanine nucleotide exchange factor (GEF) for its GTP-binding protein partner eIF2.
The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response.
Sablina et al., Leuven, Belgium. In Nat Cell Biol, 2013
The RAS-like GTPase RALB mediates cellular responses to nutrient availability or viral infection by respectively engaging two components of the exocyst complex, EXO84 and SEC5.
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton.
Montcouquiol et al., Bordeaux, France. In Nat Cell Biol, 2013
Here, we show that deletion of GTP-binding protein alpha-i subunit 3 (Gαi3) and mammalian Partner of inscuteable (mPins) disrupts the migration of the kinocilium at the surface of cochlear hair cells and affects hair bundle orientation and shape.
RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.
Camonis et al., Paris, France. In J Biol Chem, 2012
the existence of an ubiquitination/de-ubiquitination cycle superimposed on the GDP/GTP cycle of RalA, involved in the regulation of RalA activity as well as in membrane raft trafficking.
Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway.
Pepperkok et al., Dublin, Ireland. In Nat Cell Biol, 2012
Network analyses revealed a so far unappreciated link between early secretory pathway function, small GTP-binding protein regulation, actin cytoskeleton organization and EGF-receptor-mediated signalling.
Phosphorylation by protein kinase Cα regulates RalB small GTPase protein activation, subcellular localization, and effector utilization.
Der et al., Chapel Hill, United States. In J Biol Chem, 2012
phosphorylation by PKCalpha is critical for RalB-mediated vesicle trafficking and exocytosis.
The RalB small GTPase mediates formation of invadopodia through a GTPase-activating protein-independent function of the RalBP1/RLIP76 effector.
Der et al., Chapel Hill, United States. In Mol Cell Biol, 2012
a novel RalB-mediated biochemical and signaling mechanism for invadopodium formation
RalA and RalB differentially regulate development of epithelial tight junctions.
Yeaman et al., Iowa City, United States. In Mol Biol Cell, 2011
RalA and RalB differentially regulate development of epithelial tight junctions.
Ral GTPases regulate cell-mediated cytotoxicity in NK cells.
González-García et al., Madrid, Spain. In J Immunol, 2011
Our results identify a role for RalA and RalB in cell-mediated cytotoxicity
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