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Glutathione S-transferase alpha 1

GSTA1, GSTA1-1, glutathione S-transferase alpha
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008] (from NCBI)
Top mentioned proteins: GST, GSTM1, GSTT1, HAD, CAN
Papers using GSTA1 antibodies
Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury.
Kumagai Yoshito et al., In Environmental Health Perspectives, 2006
... Anti-GSTA1 was purchased from Oxford Biomedical Research (Oxford, MI, USA) ...
Papers on GSTA1
Hepatoprotective effects of Solanum nigrum against ethanol-induced injury in primary hepatocytes and mice with analysis of glutathione S-transferase A1.
Lin et al., Harbin, China. In J Chin Med Assoc, Feb 2016
The purpose of this study was to investigate the protective effects of S. nigrum against alcoholic liver damage in primary hepatocytes and mice, using glutathione S-transferase alpha 1 (GSTA1) as an indicator.
Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients.
Krajinovic et al., Genève, Switzerland. In Bone Marrow Transplant, Jan 2016
Since Bu is mainly metabolized by glutathione S-transferase (GST), we investigated the relationship of GSTA1 and GSTM1 genotypes with first-dose PK and HSCT outcomes in 44 children with thalassemia intermedia and thalassemia major.
Benzene oxide is a substrate for glutathione S-transferases.
Hecht et al., Minneapolis, United States. In Chem Biol Interact, Jan 2016
Therefore, we incubated GSTA1, GSTT1, GSTM1, and GSTP1 with glutathione and BO and quantified the formation of S-phenylglutathione. Kinetic parameters were determined for GSTT1 and GSTP1.
Supporting data for characterization of the busulfan metabolite EdAG and the Glutaredoxins that it adducts.
Atkins et al., Washington, D.C., United States. In Data Brief, Dec 2015
EdAG glutathionylates Glutaredoxins (Grx's) but not glutathione transferase A1-1 (GSTA1-1) in vitro.
The Transcription Factor MEF2 Is a Novel Regulator of Gsta Gene Class in Mouse MA-10 Leydig Cells.
Tremblay et al., Québec, Canada. In Endocrinology, Dec 2015
Similar results were obtained on the Gsta2, Gsta3, and Gsta4 promoters, suggesting a global role for MEF2 factors in the regulation of all 4 Gsta genes.
Age-specific Regulation of Drug-processing Genes in Mouse Liver by Ligands of Xenobiotic-sensing Transcription Factors.
Cui et al., Seattle, United States. In Drug Metab Dispos, Dec 2015
The inducibility of DPGs was age-specific: 1) during neonatal age, the highest fold-increase in the mRNA expression was observed for Cyp1a2, Sult5a1 and Ugt1a9 by TCDD; Cyp3a11 and Mrp2 by TCPOBOP; as well as Gstm2 and Gstm3 by PCN; 2) during adolescent age, the highest fold-increase in the mRNA expression was observed for Ugt1a6 and Mrp4 by TCDD; Cyp2b10, Ugt2b34, and Ugt2b35 by TCPOBOP; as well as Gsta1, Gsta4, Sult1e1, Ugt1a1, Mrp3, and Mrp4 by PCN; 3) in adults, the highest fold-increase in the mRNA expression was observed for Aldh1a1, Aldh1a7, and Ugt2b36 by TCPOBOP; as well as Papss2 and Oatp1a4 by PCN.
GSTA1 gene variation associated with gestational hypertension and its involvement in pregnancy-related pathogenic conditions.
Fuciarelli et al., Roma, Italy. In Eur J Obstet Gynecol Reprod Biol, Nov 2015
We calculated odds ratios (ORs), adjusted for the confounding variables, to estimate the association between GSTA1 and GH.
GSTA1, GSTM1, GSTP1 and GSTT1 polymorphisms in progressive myoclonus epilepsy: A Serbian case-control study.
Pljesa-Ercegovac et al., Belgrade, Serbia. In Seizure, Nov 2015
METHODS: GSTA1, GSTM1, GSTP1 and GSTT1 genotypes were determined in 26 patients with PME and 66 controls.
Tubular Injury Biomarkers to Detect Gentamicin-Induced Acute Kidney Injury in the Neonatal Intensive Care Unit.
Pickkers et al., Nijmegen, Netherlands. In Am J Perinatol, Oct 2015
Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-β-D-glucosaminidase (NAG), and π- and α-glutathione-S-transferase (GSTP1-1 and GSTA1-1) were measured every 2 hours during admission and compared with serum creatinine (sCr) and urine output.
Mechanisms of estrogen carcinogenesis: The role of E2/E1-quinone metabolites suggests new approaches to preventive intervention--A review.
Yager, Baltimore, United States. In Steroids, Jul 2015
Treatment with sulforaphane increased NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione-S-transferase A1 (GSTA1) expression without affecting expression of catechol-O-methyltransferase (COMT) or cytochrome P450 1B1.
Polymorphisms of GSTA1 contribute to elevated cancer risk: evidence from 15 studies.
Wang et al., Nanjing, China. In J Buon, 2015
As a vital component of GSTs, GSTA1 plays an important role in carcinogenesis.
Population pharmacokinetics and pharmacodynamics of busulfan with GSTA1 polymorphisms in patients undergoing allogeneic hematopoietic stem cell transplantation.
Oh et al., Seoul, South Korea. In Pharmacogenomics, 2014
AIM: A population pharmacokinetic (PPK) analysis was conducted to describe the influence of GSTA1 polymorphisms on intravenous busulfan in adults undergoing allogeneic hematopoietic stem cell transplantation.
Glutathione S-transferase genes and the risk of recurrent miscarriage in Italian women.
Fuciarelli et al., Roma, Italy. In Fertil Steril, 2012
A significant association is found between the GSTA1 gene and an increased risk of recurrent miscarriage.
Common variants of GSTP1, GSTA1, and TGFβ1 are associated with the risk of radiation-induced fibrosis in breast cancer patients.
Krengli et al., Novara, Italy. In Int J Radiat Oncol Biol Phys, 2012
After adjustment of confounding factors, GSTP1 Ile105Val, GSTA1 C-69T, and TGFbeta1 T869C polymorphisms were found to be significantly associated with the risk of Grade 2-3 radiation-induced fibrosis.
Nephrotoxicity of hexachloro-1:3-butadiene in the male Hanover Wistar rat; correlation of minimal histopathological changes with biomarkers of renal injury.
York et al., Ware, United Kingdom. In J Appl Toxicol, 2012
The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1.
Functional polymorphisms of GSTA1 and GSTO2 genes associated with asthma in Italian children.
Fuciarelli et al., Roma, Italy. In Clin Chem Lab Med, 2012
GSTA1 and the GSTO2 are asthma susceptible genes involved in increasing the risk of asthma development in the Italian population
Ensemble perspective for catalytic promiscuity: calorimetric analysis of the active site conformational landscape of a detoxification enzyme.
Atkins et al., Seattle, United States. In J Biol Chem, 2012
The barrierless rearrangement of the GSTA1-1 active site within a local smooth energy landscape suggests a thermodynamic basis for catalytic promiscuity
Regulation of the cardiac muscle ryanodine receptor by glutathione transferases.
Board et al., Canberra, Australia. In Drug Metab Rev, 2011
In this review, we compare functional and physical interactions between members of the GST family, including GSTO1-1, GSTA1-1, and GSTM2-2, with RyR2 and with the skeletal isoform of the ryanodine receptor (RyR1).
GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis.
Sergentanis et al., Athens, Greece. In Eur J Cancer, 2010
GSTA1 *A/*B polymorphism was not associated with colorectal cancer risk.
An overview of the relations between polymorphisms in drug metabolising enzymes and drug transporters and survival after cancer drug treatment.
Huitema et al., Amsterdam, Netherlands. In Cancer Treat Rev, 2009
Genetic polymorphisms in GSTP1 and GSTA1 are also associated with an increased overall survival in patients with different malignancies.
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