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Gasdermin B

GSDML, Gasdermin-like, GSDMB, PRO2521
This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding. [provided by RefSeq, Sep 2009] (from NCBI)
Top mentioned proteins: ZPBP2, HAD, AGE, T1/ST2, CIs
Papers on GSDML
Heritability and confirmation of genetic association studies for childhood asthma in twins.
Almqvist et al., Stockholm, Sweden. In Allergy, Feb 2016
Associations for six SNPs with asthma were replicated, including rs2305480 in the GSDMB gene (OR 0.80, 95% CI 0.74-0.86,
Genetic Determinants of Enterovirus Infections: Polymorphisms in Type 1 Diabetes and Innate Immune Genes in the MIDIA Study.
Rønningen et al., Oslo, Norway. In Viral Immunol, Dec 2015
The most significant association was with two T1D SNPs, rs12150079 (ZPBP2/ORMDL3/GSDMB region) (enterovirus frequency: AA 7.3%, AG 8.7%, GG 9.7%, RR = 0.86, overall p = 1.87E-02) and rs229541 (C1QTNF6/SSTR3/RAC2) (enterovirus frequency: CC 7.8%, CT 9.7%, TT 9.4%, RR = 1.13, overall p = 3.6E-02), followed by TLR8 (rs2407992) (p = 3.8E-02), TLR3 (1914926) (p = 4.9E-02), and two other T1D SNPs (IFIH1 rs3747517, p = 4.9E-02 and PTPN22, rs2476601, p = 5.3E-02).
Polymorphisms of RAD50, IL33 and IL1RL1 are associated with atopic asthma in Chinese population.
Xue et al., Taizhou, China. In Tissue Antigens, Dec 2015
This study aimed to investigate whether the genetic polymorphisms of CDHR3 (rs6967330), GSDMB (rs2305480), IL33 rs928413, RAD50 (rs6871536) and IL1RL1 (rs1558641) are associated with the development of atopic asthma in Chinese population.
The Early Development of Wheeze: Environmental Determinants and Genetic Susceptibility at 17q21.
PASTURE study group et al., Los Angeles, United States. In Am J Respir Crit Care Med, Dec 2015
Single nucleotide polymorphisms related to ORMDL3 (rs8076131) and GSDMB (rs7216389, rs2290400) at 17q21 were genotyped.
Genetic effects of multiple asthma loci identified by genome-wide association studies on asthma and spirometric indices.
Leung et al., Hong Kong, Hong Kong. In Pediatr Allergy Immunol, Dec 2015
CONCLUSIONS: IL13 and GSDMB are replicated as asthma genes.
Genome-wide association studies (GWAS) and their importance in asthma.
Dávila et al., Salamanca, Spain. In Allergol Immunopathol (madr), Nov 2015
The first GWAS was published in 2007, and described a new locus associated to asthma in chromosome 17q12-q21, involving the ORMDL3, GSDMB and ZPBP2 genes (a description of the genes named in the manuscript are listed in Table 1).
Gene Expression-Genotype Analysis Implicates GSDMA, GSDMB, and LRRC3C as Contributors to Inflammatory Bowel Disease Susceptibility.
Almer et al., Jönköping, Sweden. In Biomed Res Int, 2014
The susceptibility allele was consistently associated with reduced expression of GSDMB (P = 4.1 × 10(-3)-7.2
A phase I/II trial of epirubicin and docetaxel in locally advanced breast cancer (LABC) on 2-weekly or 3-weekly schedules: NCIC CTG MA.22.
Parissenti et al., Toronto, Canada. In Springerplus, 2014
Pre-treatment expression of several genes was associated with clinical response, including those within a likely amplicon at 17q12 (ERBB2, TCAP, GSDMB, and PNMT).
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.
Bisgaard et al., Copenhagen, Denmark. In Nat Genet, 2014
Four of these, GSDMB, IL33, RAD50 and IL1RL1, were previously reported as asthma susceptibility loci, but the effect sizes for these loci in our cohort were considerably larger than in the previous genome-wide association studies of asthma.
Rhinovirus wheezing illness and genetic risk of childhood-onset asthma.
Ober et al., Chicago, United States. In N Engl J Med, 2013
Moreover, the expression levels of ORMDL3 and of GSDMB were significantly increased in HRV-stimulated PBMCs, as compared with unstimulated PBMCs.
Genetics of onset of asthma.
Koppelman et al., Groningen, Netherlands. In Curr Opin Allergy Clin Immunol, 2013
Genome-wide association (GWA) studies have identified a locus on chromosome 17q12-21 (encoding ORMDL3 and GSDMB) as a risk factor for predominantly childhood-onset asthma, but not for atopy, and overall not for adult-onset asthma.
Genetic variants on 17q21 are associated with asthma in a Han Chinese population.
Li et al., Guangzhou, China. In Genet Mol Res, 2011
Significant associations between two SNPs, rs2305480 and rs8067378 in the GSDML gene, and asthma were found in this study.
[Genome-wide association study of bronchial asthma in the Volga-Ural region of Russia].
Khusnutdinova et al., In Mol Biol (mosk), 2011
Five markers on chromosome 17q12-21 showed statistically significant association with bronchial asthma .SNP rs7216389 with the strongest evidence for association is located within the first intron of the GSDMB gene.
Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR.
Hong et al., Seoul, South Korea. In Pediatr Pulmonol, 2011
The GSDMA (rs7212938) and GSDMB (rs7216389) polymorphisms are associated with asthma susceptibility and intermediate asthma phenotypes.
The genetics of asthma and allergic disease: a 21st century perspective.
Yao et al., Chicago, United States. In Immunol Rev, 2011
In contrast, variation at the 17q21 asthma locus, encoding the ORMDL3 and GSDML genes, is specifically associated with risk for childhood onset asthma.
Genome-wide association studies for discovery of genes involved in asthma.
Sandford et al., Vancouver, Canada. In Respirology, 2011
The first GWAS for asthma discovered a novel associated locus on chromosome 17q21 encompassing the genes ORMDL3, GSDMB and ZPBP2.
A large-scale, consortium-based genomewide association study of asthma.
GABRIEL Consortium et al., London, United Kingdom. In N Engl J Med, 2010
Association with the ORMDL3/GSDMB locus on chromosome 17q21 was specific to childhood-onset disease (rs2305480, P=6×10(−23)).
Genetics of allergic disease.
Holgate et al., Southampton, United Kingdom. In J Allergy Clin Immunol, 2010
This has resulted in increasing insight into novel areas of allergic disease pathophysiology, for example the significant role played by locally acting tissue susceptibility factors like epithelial/epidermal barrier function and remodeling, such as filaggrin, ADAM33, and GSDML/ORMDL3, in patients with atopic dermatitis and asthma.
Allele-specific chromatin remodeling in the ZPBP2/GSDMB/ORMDL3 locus associated with the risk of asthma and autoimmune disease.
Naumova et al., Québec, Canada. In Am J Hum Genet, 2009
The disease-linked haplotype and putative causal DNA variants of ZPBP2/GSDMB/ORMDL3 locus via a combination of genetic and functional analyses, were identified.
Genetic variation in ORM1-like 3 (ORMDL3) and gasdermin-like (GSDML) and childhood asthma.
London et al., United States. In Allergy, 2009
polymorphisms in ORMDL3 and the adjacent GSDML may contribute to childhood asthma.
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