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GoPubMed Proteins lists recent and important papers and reviews for proteins. Page last changed on 19 Dec 2016.

Glutaredoxin 3

Grx3, PICOT, PKC-interacting cousin of thioredoxin, glutaredoxin 3, TXNL2
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010] (from NCBI)
Top mentioned proteins: Thioredoxin, thioltransferase, ACID, CAN, V1a
Papers on Grx3
Elucidating the Molecular Function of Human BOLA2 in GRX3-Dependent Anamorsin Maturation Pathway.
Muzzioli et al., Sesto Fiorentino, Italy. In J Am Chem Soc, Jan 2016
To investigate the still unknown functional role of the interaction between human glutaredoxin-3 (GRX3) and its protein partner BOLA2, we characterized at the atomic level the interaction of apo BOLA2 with the apo and holo states of GRX3 and studied the role of BOLA2 in the GRX3-dependent anamorsin maturation pathway.
Evolving the PICOT Method for the Digital Age: The PICOT-D.
Convoy et al., In J Nurs Educ, Oct 2015
BACKGROUND: Many articles written about the PICOT (Population, Intervention, Comparison, Outcome, Time) method for developing research questions focus on searching the existing evidence base to review the impact of interventions.
N-terminal domains mediate [2Fe-2S] cluster transfer from glutaredoxin-3 to anamorsin.
Winkelmann et al., Florence, Italy. In Nat Chem Biol, Oct 2015
We define a new role of human cytosolic monothiol glutaredoxin-3 (GRX3) in transferring its [2Fe-2S] clusters to human anamorsin, a physical and functional protein partner of GRX3 in the cytosol, whose [2Fe-2S] cluster-bound form is involved in the biogenesis of cytosolic and nuclear Fe-S proteins.
Aprepitant: A New Modality for the Prevention of Postoperative Nausea and Vomiting: An Evidence-Based Review.
Amos et al., In J Perianesth Nurs, Oct 2015
METHODS: A literature search was conducted to answer the population-intervention-comparison-outcome-time (PICOT) question: In adult patients undergoing general anesthesia (P), does aprepitant (I) decrease PONV (O) postoperatively (T) as compared to patients receiving other antiemetic therapy or a placebo (C)?
Human glutaredoxin 3 can bind and effectively transfer [4Fe-4S] cluster to apo-iron regulatory protein 1.
Li et al., Nanjing, China. In Biochem Biophys Res Commun, Oct 2015
Glutaredoxin 3 (GLRX3) is a member of monothiol glutaredoxins with a CGFS active site that has been demonstrated to function in cellular iron sensing and trafficking via its bound iron-sulfur cluster.
Impact of commissioning weight-loss surgery for bariatric patients.
Petty, London, United Kingdom. In Br J Nurs, Sep 2015
This has been shown to be a clinically and cost effective weight-loss treatment option (Picot et al, 2009), but is invasive and expensive compared with non-surgical weight-loss programmes.
Nuclear glutaredoxin 3 is critical for protection against oxidative stress-induced cell death.
Cheng et al., Houston, United States. In Free Radic Biol Med, Aug 2015
Mammalian glutaredoxin 3 (Grx3) has been shown to be critical in maintaining redox homeostasis and regulating cell survival pathways in cancer cells.
Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.
Choi et al., Seoul, South Korea. In J Biol Chem, 2015
Biochemical and mutational analyses revealed that Prx3 reduces H2O2, utilizing glutaredoxin 3 (Grx3) and glutathione (GSH) as reductants, and requires only N-terminal peroxidatic cysteine for its catalysis.
Expression changes of antioxidant, apoptotic, anti-apoptotic genes and miR-15b-34a-21-98 in over tissue by using erythromycin, quinacrine and tetracycline in non-surgical sterilization.
Kuloglu et al., Muğla, Turkey. In Mol Biol Rep, 2014
In the present study, effects on expression of antioxidant, apoptotic and anti-apoptotic genes (GSR, GRX3, SOD1, RAI-NOS, HSP7, BAX, Bcl-2, CASP3 and MDH1) of substances being used in non-surgical sterilization such as quinacrine, erythromycin and tetracycline were evaluated in over tissue.
Daszkiewicz, In Kwart Hist Nauki Tech, 2014
Precious information about Gilibert and his stay in Lithuania was found in the letters of Antoine Gouan (1733-1821) to Philippe-Isidore Picot de Lapeyrouse (1744-1818).
Strategies for searching and managing evidence-based practice resources.
Shellenbarger et al., In J Contin Educ Nurs, 2014
Strategies also are recommended for refining searches by using controlled vocabulary, truncation, Boolean operators, PICOT (Population/Patient Problem, Intervention, Comparison, Outcome, Time) searching, and search limits.
A look at the potential association between PICOT framing of a research question and the quality of reporting of analgesia RCTs.
Thabane et al., Hamilton, Canada. In Bmc Anesthesiol, 2012
Five constituents of a good research question based on the PICOT framing include: Population, Intervention, Comparator, Outcome, and Time-frame of outcome assessment.
Human glutaredoxin 3 forms [2Fe-2S]-bridged complexes with human BolA2.
Outten et al., Columbia, United States. In Biochemistry, 2012
the unusual [2Fe-2S]-bridging Grx-BolA interaction is conserved in higher eukaryotes and may play a role in signaling cellular iron status in humans.
Investigation of in vivo diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.
Huang et al., Cambridge, United States. In J Biol Chem, 2012
diferric tyrosyl radical formation in Saccharomyces cerevisiae Rnr2 protein: requirement of Rnr4 and contribution of Grx3/4 AND Dre2 proteins.(
Tapping the brake on cardiac growth-endogenous repressors of hypertrophic signaling.
Creemers et al., Amsterdam, Netherlands. In J Mol Cell Cardiol, 2011
PICOT, calsarcin, RCAN) and JNK signaling (e.g.
A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis.
Hirschi et al., Houston, United States. In Febs J, 2011
investigation of role of Grx3: embryos absent Grx3 were small, morphological defects, early embryonic lethality; mRNA ubiquitously expressed in developing embryos, adult tissues; induced during oxidative stress; necessary for cell cycle progression
PICOT is a molecule which binds to anamorsin.
Kanakura et al., Ōsaka, Japan. In Biochem Biophys Res Commun, 2011
These data suggest that AM and PICOT might play cooperatively essential roles in embryogenesis as iron-sulfur cluster proteins.
Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-κB signaling.
Cui et al., Shanghai, China. In J Clin Invest, 2011
analysis of primary breast cancer samples demonstrated that enhanced TXNL2 expression correlated with metastasis to the lung and brain and with decreased overall patient survival
Posing the research question: not so simple.
Paul et al., Hamilton, Canada. In Can J Anaesth, 2009
The PICOT approach requires that the framing of the research question specify the target Population, the Intervention of interest, the Comparator intervention, key Outcomes, and the Time frame over which the outcomes are assessed.
Monothiol glutaredoxins: a common domain for multiple functions.
de la Torre-Ruiz et al., Lleida, Spain. In Cell Mol Life Sci, 2007
The human PICOT protein is a Grx3/Grx4 homologue with the same hybrid primary structure that regulates protein kinase C activity and may participate in physiological processes such as control of cardiac function.
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