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Heat shock 70kDa protein 5

GRP78, BiP
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010] (from NCBI)
Top mentioned proteins: CHOP, PrP, V1a, CAN, ACID
Papers using GRP78 antibodies
ER and aging-Protein folding and the ER stress response
Lee Amy S. et al., In Cell death and differentiation, 2008
... Grp78 T/+ mice11 carrying the targeted allele (T) were mated with the EIIA-Cre transgenic mice, and generated offspring ...
Biodegradable polymer nanoparticles that rapidly penetrate the human mucus barrier.
Dalmasso Guillaume, In PLoS ONE, 2008
... Rabbit anti-GRP78 (BiP) antibody was obtained from Abcam (Cambridge, MA, USA) ...
Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22(Phox) and iNOS expression
Blanco Francisco J et al., In Arthritis Research & Therapy, 2007
... Louis, MO, USA), antibody against human GRP78 and the correspondent peroxidase-conjugated secondary antibodies from Santa Cruz Biotechnology (Santa Cruz, CA, USA) ...
A proteomic screen identified stress-induced chaperone proteins as targets of Akt phosphorylation in mesangial cells.
Cheriyath Venugopalan, In PLoS ONE, 2005
... Anti-p70 S6 kinase, Anti-phospho-AKT (Thr308), Anti-AKT1, and anti-GRP78 (N-20) were from Santa Cruz Biotechnologies (Insight Biotechnology Ltd, UK) ...
Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer
Wyld L et al., In British Journal of Cancer, 2005
... Anti-GRP78 goat polyclonal antibody (sc-1050, Santa Cruz Biotechnology Inc., Santa Cruz, CA, ...
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Papers on GRP78
Endoplasmic reticulum-associated degradation of the mouse PC1/3-N222D hypomorph and human PCSK1 mutations contributes to obesity.
Creemers et al., Leuven, Belgium. In Int J Obes (lond), Feb 2016
Coimmunoprecipitation of PC1/3-N222D and human PC1/3 variants associated with obesity with the ER chaperone BiP was studied in cell lines.
Endoplasmic reticulum stress responses function in the HRT-mediated hypersensitive response in Nicotiana benthamiana.
Park et al., Taejŏn, South Korea. In Mol Plant Pathol, Feb 2016
VIGS of CaBLP5, which encodes an endoplasmic reticulum (ER)-associated immunoglobulin-binding protein (BiP), silenced NbBiP4 and NbBiP5 and significantly reduced HRT-mediated HR.
IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation.
Qi et al., Ithaca, United States. In Nat Cell Biol, Dec 2015
ERAD-mediated IRE1α degradation occurs under basal conditions in a BiP-dependent manner, requires both the intramembrane hydrophilic residues of IRE1α and the lectin protein OS9, and is attenuated by ER stress.
Sodium Butyrate Induces Endoplasmic Reticulum Stress and Autophagy in Colorectal Cells: Implications for Apoptosis.
Sun et al., Guangzhou, China. In Plos One, Dec 2015
Furthermore, sodium butyrate treatment markedly enhanced the expression of endoplasmic reticulum stress-associated proteins, including BIP, CHOP, PDI, and IRE-1a.
Interleukin-22 Alleviated Palmitate-Induced Endoplasmic Reticulum Stress in INS-1 Cells through Activation of Autophagy.
Zhang et al., Guangzhou, China. In Plos One, Dec 2015
The protein expression of glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), microtubule-associated protein light chain 3B (LC3B) and Bcl-2-interacting myosin-like coiled-coil protein (Beclin-1) were evaluated by western blot.
Amino-terminal arginylation targets endoplasmic reticulum chaperone BiP for autophagy through p62 binding.
Kwon et al., South Korea. In Nat Cell Biol, Jul 2015
N-terminal arginylation of BiP (also known as GRP78), protein disulphide isomerase and calreticulin is co-induced with autophagy during innate immune responses to cytosolic foreign DNA or proteasomal inhibition, associated with increased ubiquitylation.
BiP and its nucleotide exchange factors Grp170 and Sil1: mechanisms of action and biological functions.
Hendershot et al., Memphis, United States. In J Mol Biol, May 2015
BiP (immunoglobulin heavy-chain binding protein) is the endoplasmic reticulum (ER) orthologue of the Hsp70 family of molecular chaperones and is intricately involved in most functions of this organelle through its interactions with a variety of substrates and regulatory proteins.
Endoplasmic reticulum stress in periimplantation embryos.
Gye et al., Edmonton, Canada. In Clin Exp Reprod Med, Mar 2015
Various elements of coping responses to ER stress including Perk, Ask1, Bip, Chop, Gadd34, Ire1, Atf4, Atf6, and Xbp1 have been identified and were found to be inducible in oocytes and preimplantation embryos, suggesting that, as a normal part of the cellular adaptive mechanism, these coping responses, including the UPR, play a pivotal role in the development of preimplantation embryos.
Calcium homeostasis and ER stress in control of autophagy in cancer cells.
Orzechowski et al., Warsaw, Poland. In Biomed Res Int, 2014
Moreover ER molecular chaperones such as GRP78/BiP and transcription factors like CHOP participate in regulation of ER stress-mediated autophagy.
Multi-layered molecular mechanisms of polypeptide holding, unfolding and disaggregation by HSP70/HSP110 chaperones.
Goloubinoff et al., Lausanne, Switzerland. In Front Mol Biosci, 2014
The heat-inducible form HSP70 (HSPA1A) and its major cognates, cytosolic HSC70 (HSPA8), endoplasmic reticulum BIP (HSPA5), mitochondrial mHSP70 (HSPA9) and related HSP110s (HSPHs), contribute about 3% of the total protein mass of human cells.
Induction of cap-independent BiP (hsp-3) and Bcl-2 (ced-9) translation in response to eIF4G (IFG-1) depletion in C. elegans.
Keiper et al., Greenville, United States. In Translation (austin), 2013
In this study we address the translational regulation of the stress and apoptosis-related mRNAs in C. elegans: BiP (hsp-3) (hsp-4), Hif-1 (hif-1), p53 (cep-1), Bcl-2 (ced-9) and Apaf-1 (ced-4).
Endoplasmic reticulum stress in endometrial cancer.
Insabato et al., Napoli, Italy. In Front Med (lausanne), 2013
However, besides these alterations, few other groups and ourselves recently identified the activation of the unfolded protein response (UPR) and GRP78 increase following endoplasmic reticulum (ER) stress as mechanisms favoring growth and invasion of EC cells.
IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78.
Oh et al., Richmond, United States. In Cancer Lett, 2013
In antiestrogen-resistance breast cancer cells, IGFBP-3 interacted with GRP78, resulting in disruption of the GRP78-caspase-7 complex, activating caspase-7, inducing apoptosis.
ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load.
Ron et al., Cambridge, United Kingdom. In J Cell Biol, 2012
ADP ribosylation adapts a BiP ER chaperone response to short-term fluctuations in unfolded protein load
BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER.
Zimmermann et al., Homburg, Germany. In Embo J, 2012
BiP limits ER Ca(2+) leakage through the Sec61 complex by binding to the ER lumenal loop 7 of Sec61alpha in the vicinity of tyrosine 344.
Dermokine-β impairs ERK signaling through direct binding to GRP78.
Saito et al., Ōsaka, Japan. In Febs Lett, 2012
Dermokine-beta impairs ERK signaling through direct binding to GRP78
Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness.
Clarke et al., Washington, D.C., United States. In Cancer Res, 2012
findings reveal a novel role for GRP78 in the integration of cellular signaling pathways including the unfolded protein response, apoptosis, and autophagy to determine cell fate in response to antiestrogen therapy
BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.
Helenius et al., Zürich, Switzerland. In Nat Cell Biol, 2011
BAP31 and BiP are essential for dislocation of SV40 from the endoplasmic reticulum to the cytosol.
Cripto regulates hematopoietic stem cells as a hypoxic-niche-related factor through cell surface receptor GRP78.
Karlsson et al., Lund, Sweden. In Cell Stem Cell, 2011
These data suggest that Cripto/GRP78 signaling is an important pathway that regulates hematopoietic stem cell quiescence.
The tumor suppressor Par-4 activates an extrinsic pathway for apoptosis.
Rangnekar et al., Lexington, United States. In Cell, 2009
Interestingly, extracellular Par-4 induced apoptosis by binding to the stress response protein, glucose-regulated protein-78 (GRP78), expressed at the surface of cancer cells.
More papers using GRP78 antibodies
Identification of Dll1 (Delta1) target genes during mouse embryogenesis using differential expression profiling
Barsh Greg, In PLoS Genetics, 2004
... caspase-3 (R&D Systems, Germany), caspase-12 (BD Pharmingen, Germany), anti-α-tubulin (Sigma, Germany), β-actin, type I collagen, and BiP/GRP78 (all Abcam, UK), and fluorescently labeled ...
Regulation of ROS signal transduction by NADPH oxidase 4 localization
Keaney John F. et al., In The Journal of Cell Biology, 2004
... Anti-GRP78 was obtained from BD Biosciences, anticatalase and anti–histone H4 ...
Calcium orchestrates apoptosis
Cheng Ju-Chien et al., In Evidence-based Complementary and Alternative Medicine : eCAM, 2002
... The anti-Bcl-2, anti-Bax, and anti-GRP78 antibodies were purchased from Santa Cruz Biotechnology (Santa Cruz, CA) ...
Oxidized LDL in carotid plaques and plasma associates with plaque instability
Zou Ming-Hui et al., In Diabetes, 2001
... Antibodies against glucose-regulated protein 78 (GRP78) and oxidized LDL (ox-LDL) were from Abcam (Cambridge, MA) ...
Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress
Stilo Romania et al., In Journal of Cellular Physiology, 2000
... Louis, MO); anti-TRAF2, anti-BiP, anti-cleaved PARP Santa Cruz Biotechnology (Santa Cruz, CA); anti-BCL-10 ...
The renaissance of GSK3
Song Yong et al., In Mediators of Inflammation, 2000
... The following antibodies were used for Western blots: monoclonal mouse antibodies against human GRP78 (Bioworld Technology, Minneapolis, MN, USA), GSK-3β (Santa Cruz Biotechnology, Santa Cruz, CA, USA), ...
Cadmium-mediated oxidative stress in kidney proximal tubule cells induces degradation of Na+/K+-ATPase through proteasomal and endo−/lysosomal proteolytic pathways.
Maki Carl G., In PLoS ONE, 1998
... Technology (Beverly, MA); the anti-caspase 12 antibody was purchased from Abcam (Cambridge, MA); and the anti-GRP78 antibody was purchased from BD Biosciences (Sparks, MD) ...
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma
Pereira T S et al., In Cell Death & Disease, 1994
... NB100-2323, Novus Biologicals), anti-ATF6 (full-length and cleaved forms; 1:200, IMG-273, IMGENEX, San Diego, CA, USA), anti-Bip (1:500, #3177, Cell Signaling Technology), anti-CHOP (1:200, sc-575, ...
Involvement of a polyproline helix-like structure in the interaction of 7B2 with prohormone convertase 2
Lindberg Iris et al., In The Journal of Cell Biology, 1994
... The antiserum directed against BiP/GRP78 was obtained from Santa Cruz Biotechnology Inc. ...
Immunoglobulin M possesses two binding sites for complement subcomponent C1q, and soluble 1:1 and 2:1 complexes are formed in solution at reduced ionic strength
Pizzo Salvatore V., In PLoS ONE, 1984
... CD spectra for GRP78 (0.15 mg/ml) and PAT-SM6 (0.15 mg/ml) in phosphate buffered saline (PBS; 20 mM sodium phosphate, 140 mM NaCl, pH 7.4) were acquired using an Aviv Model 62 DS CD spectrometer (Aviv Biomedical, Inc, Lakewood, New Jersey) ...
Osmotic changes caused by the accumulation of dulcitol in the lenses of rats fed with galactose.
Dent Paul, In PLoS ONE, 1961
... Anti-glucose-regulated protein 78/binding immunoglobulin protein (GRP78/Bip) was obtained from Abcam, Inc ...
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